Dacomitinib

Dacomitinib Brand Name– VIZIMPRO

What is Dacomitinib

Dacomitinib is an oral, irreversible epidermal growth factor receptor (EGFR) kinase inhibitor indicated as monotherapy for the first-line treatment of metastatic non-small cell lung cancer (NSCLC) in patients with EGFR exon 19 deletions or exon 21 (L858R) substitution mutations.

EGFR is expressed, overexpressed, or dysregulated in many cancers; clinically, EGFR expression has been associated with poor prognosis, development of metastasis, and resistance to chemotherapy, hormonal therapy, and radiation therapy.

Monitor for diarrhea, dermatologic reactions, and symptoms of pneumonitis; an interruption of therapy, dose reduction, or discontinuation of therapy may be necessary.

Indications

  • non-small cell lung cancer (NSCLC)

For the first-line treatment of metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an FDA-approved test

Side Effects

  1. acneiform rash
  2. alopecia
  3. alopecia
  4. anemia
  5. anemia
  6. anorexia
  7. anorexia
  8. asthenia
  9. asthenia
  10. chest pain (unspecified)
  11. conjunctivitis
  12. constipation
  13. cough
  14. dehydration
  15. diarrhea
  16. diarrhea
  17. dysgeusia
  18. dyspnea
  19. dyspnea
  20. elevated hepatic enzymes
  21. elevated hepatic enzymes
  22. epistaxis
  23. exfoliative dermatitis
  24. exfoliative dermatitis
  25. fatigue
  26. hyperbilirubinemia
  27. hyperbilirubinemia
  28. hyperglycemia
  29. hyperglycemia
  30. hypertrichosis
  31. hypoalbuminemia
  32. hypocalcemia
  33. hypocalcemia
  34. hypokalemia
  35. hypokalemia
  36. hypomagnesemia
  37. hypomagnesemia
  38. hyponatremia
  39. hyponatremia
  40. infection
  41. infection
  42. insomnia
  43. insomnia
  44. keratitis
  45. lymphopenia
  46. lymphopenia
  47. maculopapular rash
  48. musculoskeletal pain
  49. musculoskeletal pain
  50. nausea
  51. nausea
  52. onycholysis
  53. oral ulceration
  54. palmar-plantar erythrodysesthesia (hand and foot syndrome)
  55. palmar-plantar erythrodysesthesia (hand and foot syndrome)
  56. photosensitivity
  57. pneumonitis
  58. pneumonitis
  59. pruritus
  60. pruritus
  61. rash
  62. rash
  63. rhinitis
  64. stomatitis
  65. stomatitis
  66. vomiting
  67. weight loss
  68. weight loss
  69. xerosis
  70. xerosis

Monitoring Parameters

  • pregnancy testing

Contraindications

  • breast-feeding
  • chronic lung disease (CLD)
  • contraception requirements
  • diarrhea
  • geriatric
  • infertility
  • interstitial lung disease
  • pneumonitis
  • pregnancy
  • pregnancy testing
  • pulmonary disease
  • reproductive risk
  • serious rash
  • sunlight (UV) exposure

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Tramadol
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamines
  • Aripiprazole
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Omeprazole
  • Atomoxetine
  • Benzphetamine
  • Brexpiprazole
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carvedilol
  • Cevimeline
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Cimetidine
  • Clomipramine
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Desipramine
  • Deutetrabenazine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexlansoprazole
  • Dextroamphetamine
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Donepezil
  • Donepezil; Memantine
  • Doxepin
  • Doxorubicin
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Eliglustat
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Famotidine
  • Famotidine; Ibuprofen
  • Flecainide
  • Galantamine
  • Gefitinib
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Iloperidone
  • Imipramine
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Lisdexamfetamine
  • Lofexidine
  • Maprotiline
  • Methadone
  • Methamphetamine
  • Metoclopramide
  • Metoprolol
  • Mexiletine
  • Nebivolol
  • Nebivolol; Valsartan
  • Nizatidine
  • Nortriptyline
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Pantoprazole
  • Paroxetine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Pimozide
  • Pitolisant
  • Propafenone
  • Propranolol
  • Protriptyline
  • Rabeprazole
  • Ranitidine
  • Risperidone
  • Tamoxifen
  • Tamsulosin
  • Tetrabenazine
  • Thioridazine
  • Tramadol
  • Tricyclic antidepressants
  • Trimipramine
  • Valbenazine
  • Venlafaxine
  • Vortioxetine
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856