Dacomitinib Brand Name– VIZIMPRO
What is Dacomitinib
Dacomitinib is an oral, irreversible epidermal growth factor receptor (EGFR) kinase inhibitor indicated as monotherapy for the first-line treatment of metastatic non-small cell lung cancer (NSCLC) in patients with EGFR exon 19 deletions or exon 21 (L858R) substitution mutations.
EGFR is expressed, overexpressed, or dysregulated in many cancers; clinically, EGFR expression has been associated with poor prognosis, development of metastasis, and resistance to chemotherapy, hormonal therapy, and radiation therapy.
Monitor for diarrhea, dermatologic reactions, and symptoms of pneumonitis; an interruption of therapy, dose reduction, or discontinuation of therapy may be necessary.
Indications
- non-small cell lung cancer (NSCLC)
For the first-line treatment of metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an FDA-approved test
Side Effects
- acneiform rash
- alopecia
- alopecia
- anemia
- anemia
- anorexia
- anorexia
- asthenia
- asthenia
- chest pain (unspecified)
- conjunctivitis
- constipation
- cough
- dehydration
- diarrhea
- diarrhea
- dysgeusia
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- epistaxis
- exfoliative dermatitis
- exfoliative dermatitis
- fatigue
- hyperbilirubinemia
- hyperbilirubinemia
- hyperglycemia
- hyperglycemia
- hypertrichosis
- hypoalbuminemia
- hypocalcemia
- hypocalcemia
- hypokalemia
- hypokalemia
- hypomagnesemia
- hypomagnesemia
- hyponatremia
- hyponatremia
- infection
- infection
- insomnia
- insomnia
- keratitis
- lymphopenia
- lymphopenia
- maculopapular rash
- musculoskeletal pain
- musculoskeletal pain
- nausea
- nausea
- onycholysis
- oral ulceration
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- photosensitivity
- pneumonitis
- pneumonitis
- pruritus
- pruritus
- rash
- rash
- rhinitis
- stomatitis
- stomatitis
- vomiting
- weight loss
- weight loss
- xerosis
- xerosis
Monitoring Parameters
- pregnancy testing
Contraindications
- breast-feeding
- chronic lung disease (CLD)
- contraception requirements
- diarrhea
- geriatric
- infertility
- interstitial lung disease
- pneumonitis
- pregnancy
- pregnancy testing
- pulmonary disease
- reproductive risk
- serious rash
- sunlight (UV) exposure
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Tramadol
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Aripiprazole
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Atomoxetine
- Benzphetamine
- Brexpiprazole
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carvedilol
- Cevimeline
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cimetidine
- Clomipramine
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Desipramine
- Deutetrabenazine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexlansoprazole
- Dextroamphetamine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Donepezil
- Donepezil; Memantine
- Doxepin
- Doxorubicin
- Duloxetine
- Dutasteride; Tamsulosin
- Eliglustat
- Esomeprazole
- Esomeprazole; Naproxen
- Famotidine
- Famotidine; Ibuprofen
- Flecainide
- Galantamine
- Gefitinib
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Iloperidone
- Imipramine
- Lansoprazole
- Lansoprazole; Naproxen
- Lisdexamfetamine
- Lofexidine
- Maprotiline
- Methadone
- Methamphetamine
- Metoclopramide
- Metoprolol
- Mexiletine
- Nebivolol
- Nebivolol; Valsartan
- Nizatidine
- Nortriptyline
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Pantoprazole
- Paroxetine
- Perphenazine
- Perphenazine; Amitriptyline
- Pimozide
- Pitolisant
- Propafenone
- Propranolol
- Protriptyline
- Rabeprazole
- Ranitidine
- Risperidone
- Tamoxifen
- Tamsulosin
- Tetrabenazine
- Thioridazine
- Tramadol
- Tricyclic antidepressants
- Trimipramine
- Valbenazine
- Venlafaxine
- Vortioxetine