Cyproheptadine Brand Name– Periactin
What is Cyproheptadine
Cyproheptadine is a piperidine H1-antagonist. Unlike other H1-antagonists, this drug also antagonizes serotonin receptors.
This action makes cyproheptadine useful in conditions such as Cushing’s syndrome, vascular headache and anorexia.
Cyproheptadine has also been used for the management of anorgasmy caused by antidepressants such as SSRIs; however, it must be monitored closely when used for this purpose since the antidepressant effects of the SSRI may also be reversed.
In a small study, patients with chronic urticaria ranked cyproheptadine higher than five other H1-antagonists in efficacy and freedom from side effects.
Cyproheptadine was approved by the FDA in 1961.
Indications
- allergic conjunctivitis
- allergic rhinitis
- anaphylaxis
- angioedema
- anorexia
- anorgasmy
- Cushing’s syndrome
- dermatographism
- migraine prophylaxis
- pruritus
- spasticity
- urticaria
- vasomotor rhinitis
Side Effects
- agranulocytosis
- anaphylactic shock
- anorexia
- appetite stimulation
- blurred vision
- bronchial secretions
- chills
- cholestasis
- confusion
- constipation
- diarrhea
- diplopia
- dizziness
- drowsiness
- dyspepsia
- edema
- euphoria
- excitability
- fatigue
- hemolytic anemia
- hepatic failure
- hepatitis
- hyperhidrosis
- hypotension
- impaired cognition
- increased urinary frequency
- insomnia
- irritability
- jaundice
- leukopenia
- nasal congestion
- nausea
- neuritis
- paresthesias
- photosensitivity
- rash
- restlessness
- seizures
- sinus tachycardia
- thrombocytopenia
- tinnitus
- tremor
- urinary retention
- urticaria
- vertigo
- vomiting
- weight gain
- wheezing
- xerostomia
Monitoring Parameters
- ECG
- LFTs
Contraindications
- anticholinergic medications
- asthma
- bladder obstruction
- breast-feeding
- cardiac disease
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- contact lenses
- driving or operating machinery
- geriatric
- GI obstruction
- hepatic disease
- ileus
- infants
- MAOI therapy
- neonates
- peptic ulcer disease
- pregnancy
- prostatic hypertrophy
- urinary retention
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Alfentanil
- Alosetron
- Amantadine
- Ambenonium Chloride
- Amobarbital
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Anticholinergics
- Apomorphine
- Aripiprazole
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atracurium
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzphetamine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Butorphanol
- Cannabidiol
- Capsaicin; Metaxalone
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carisoprodol
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorzoxazone
- Cisatracurium
- Citalopram
- Clobazam
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclobenzaprine
- Dantrolene
- Desloratadine
- Desloratadine; Pseudoephedrine
- Deutetrabenazine
- Dexmedetomidine
- Dextroamphetamine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Donepezil
- Donepezil; Memantine
- Doxacurium
- Dronabinol
- Droperidol
- Entacapone
- Escitalopram
- Esketamine
- Eszopiclone
- Ethanol
- Etomidate
- Ezogabine
- Fentanyl
- Flibanserin
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Fospropofol
- Gabapentin
- Galantamine
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Halogenated Anesthetics
- Haloperidol
- Heparin
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen; Oxycodone
- Iloperidone
- Isocarboxazid
- Ketamine
- Lasmiditan
- Levocetirizine
- Levomethadyl
- Levorphanol
- Lofexidine
- Loratadine
- Loratadine; Pseudoephedrine
- Loxapine
- Lumateperone
- Lurasidone
- Magnesium Salts
- Maprotiline
- Meclizine
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Metaxalone
- Methadone
- Methamphetamine
- Methocarbamol
- Methohexital
- Metoclopramide
- Metyrosine
- Minocycline
- Mirtazapine
- Mitotane
- Mivacurium
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nefazodone
- Neuromuscular blockers
- Olanzapine
- Opiate Agonists
- Orphenadrine
- Oxycodone
- Oxymorphone
- Paliperidone
- Pancuronium
- Paroxetine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Phenelzine
- Phenobarbital
- Pimozide
- Pitolisant
- Pramipexole
- Pregabalin
- Primidone
- Procarbazine
- Propofol
- Propoxyphene
- Quetiapine
- Ramelteon
- Rapacuronium
- Rasagiline
- Remifentanil
- Risperidone
- Rituximab; Hyaluronidase
- Rivastigmine
- Rocuronium
- Ropinirole
- Safinamide
- Secobarbital
- Selegiline
- Sertraline
- Sincalide
- Sodium Iodide
- Solifenacin
- Succinylcholine
- Sufentanil
- Suvorexant
- Tacrine
- Tapentadol
- Tasimelteon
- Thalidomide
- Thiopental
- Thiothixene
- Tizanidine
- Tolcapone
- Tramadol
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Trazodone
- Tricyclic antidepressants
- Trimethobenzamide
- Trospium
- Tubocurarine
- Vecuronium
- Venlafaxine
- Vigabatrin
- Vilazodone
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolpidem