Cyproheptadine

Cyproheptadine Brand Name– Periactin

What is Cyproheptadine

Cyproheptadine is a piperidine H1-antagonist. Unlike other H1-antagonists, this drug also antagonizes serotonin receptors.

This action makes cyproheptadine useful in conditions such as Cushing’s syndrome, vascular headache and anorexia.

Cyproheptadine has also been used for the management of anorgasmy caused by antidepressants such as SSRIs; however, it must be monitored closely when used for this purpose since the antidepressant effects of the SSRI may also be reversed.

In a small study, patients with chronic urticaria ranked cyproheptadine higher than five other H1-antagonists in efficacy and freedom from side effects.

Cyproheptadine was approved by the FDA in 1961.

Indications

  1. allergic conjunctivitis
  2. allergic rhinitis
  3. anaphylaxis
  4. angioedema
  5. anorexia
  6. anorgasmy
  7. Cushing’s syndrome
  8. dermatographism
  9. migraine prophylaxis
  10. pruritus
  11. spasticity
  12. urticaria
  13. vasomotor rhinitis

Side Effects

  1. agranulocytosis
  2. anaphylactic shock
  3. anorexia
  4. appetite stimulation
  5. blurred vision
  6. bronchial secretions
  7. chills
  8. cholestasis
  9. confusion
  10. constipation
  11. diarrhea
  12. diplopia
  13. dizziness
  14. drowsiness
  15. dyspepsia
  16. edema
  17. euphoria
  18. excitability
  19. fatigue
  20. hemolytic anemia
  21. hepatic failure
  22. hepatitis
  23. hyperhidrosis
  24. hypotension
  25. impaired cognition
  26. increased urinary frequency
  27. insomnia
  28. irritability
  29. jaundice
  30. leukopenia
  31. nasal congestion
  32. nausea
  33. neuritis
  34. paresthesias
  35. photosensitivity
  36. rash
  37. restlessness
  38. seizures
  39. sinus tachycardia
  40. thrombocytopenia
  41. tinnitus
  42. tremor
  43. urinary retention
  44. urticaria
  45. vertigo
  46. vomiting
  47. weight gain
  48. wheezing
  49. xerostomia

Monitoring Parameters

  • ECG
  • LFTs

Contraindications

  • anticholinergic medications
  • asthma
  • bladder obstruction
  • breast-feeding
  • cardiac disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • contact lenses
  • driving or operating machinery
  • geriatric
  • GI obstruction
  • hepatic disease
  • ileus
  • infants
  • MAOI therapy
  • neonates
  • peptic ulcer disease
  • pregnancy
  • prostatic hypertrophy
  • urinary retention

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Alfentanil
  • Alosetron
  • Amantadine
  • Ambenonium Chloride
  • Amobarbital
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Anticholinergics
  • Apomorphine
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atracurium
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Baclofen
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzphetamine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carisoprodol
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorzoxazone
  • Cisatracurium
  • Citalopram
  • Clobazam
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclobenzaprine
  • Dantrolene
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Deutetrabenazine
  • Dexmedetomidine
  • Dextroamphetamine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Donepezil
  • Donepezil; Memantine
  • Doxacurium
  • Dronabinol
  • Droperidol
  • Entacapone
  • Escitalopram
  • Esketamine
  • Eszopiclone
  • Ethanol
  • Etomidate
  • Ezogabine
  • Fentanyl
  • Flibanserin
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluvoxamine
  • Fospropofol
  • Gabapentin
  • Galantamine
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halogenated Anesthetics
  • Haloperidol
  • Heparin
  • Homatropine; Hydrocodone
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydantoins
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Iloperidone
  • Isocarboxazid
  • Ketamine
  • Lasmiditan
  • Levocetirizine
  • Levomethadyl
  • Levorphanol
  • Lofexidine
  • Loratadine
  • Loratadine; Pseudoephedrine
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Magnesium Salts
  • Maprotiline
  • Meclizine
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Metaxalone
  • Methadone
  • Methamphetamine
  • Methocarbamol
  • Methohexital
  • Metoclopramide
  • Metyrosine
  • Minocycline
  • Mirtazapine
  • Mitotane
  • Mivacurium
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nefazodone
  • Neuromuscular blockers
  • Olanzapine
  • Opiate Agonists
  • Orphenadrine
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Pancuronium
  • Paroxetine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Phenelzine
  • Phenobarbital
  • Pimozide
  • Pitolisant
  • Pramipexole
  • Pregabalin
  • Primidone
  • Procarbazine
  • Propofol
  • Propoxyphene
  • Quetiapine
  • Ramelteon
  • Rapacuronium
  • Rasagiline
  • Remifentanil
  • Risperidone
  • Rituximab; Hyaluronidase
  • Rivastigmine
  • Rocuronium
  • Ropinirole
  • Safinamide
  • Secobarbital
  • Selegiline
  • Sertraline
  • Sincalide
  • Sodium Iodide
  • Solifenacin
  • Succinylcholine
  • Sufentanil
  • Suvorexant
  • Tacrine
  • Tapentadol
  • Tasimelteon
  • Thalidomide
  • Thiopental
  • Thiothixene
  • Tizanidine
  • Tolcapone
  • Tramadol
  • Tranylcypromine
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Tricyclic antidepressants
  • Trimethobenzamide
  • Trospium
  • Tubocurarine
  • Vecuronium
  • Venlafaxine
  • Vigabatrin
  • Vilazodone
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolpidem
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