Cycloserine

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Cycloserine Brand Name– Seromycin

What is Cycloserine

Cycloserine is a second-line, broad-spectrum antibiotic used in the treatment of active pulmonary and extrapulmonary tuberculosis (TB) and urinary tract infections (UTIs).

In the treatment of TB, it is given only when other antituberculars are ineffective and in cases needing retreatment.

While cycloserine has activity against some genitourinary pathogens, it is seldom used clinically for these infections.

Cycloserine also may be used to treat Mycobacterium avium complex (MAC)† when less hazardous drugs are ineffective.

Cycloserine was approved by the FDA in 1956.

Indications

  1. Enterobacter sp.
  2. Escherichia coli
  3. Mycobacterium avium
  4. Mycobacterium bovis
  5. Mycobacterium intracellulare
  6. Mycobacterium kansasii
  7. Mycobacterium marinum
  8. Mycobacterium smegmatis
  9. Mycobacterium tuberculosis
  10. Mycobacterium ulcerans
  11. Staphylococcus aureus (MSSA)
  12. tuberculosis infection
  13. urinary tract infection (UTI)

Side Effects

  1. anxiety
  2. confusion
  3. depression
  4. dizziness
  5. drowsiness
  6. dysarthria
  7. headache
  8. hyperreflexia
  9. lethargy
  10. paresis
  11. paresthesias
  12. psychosis
  13. seizures
  14. tremor
  15. vertigo
  16. vitamin B6 deficiency

Monitoring Parameters

  • CBC
  • serum creatinine/BUN
  • serum cycloserine concentrations

Contraindications

  • alcoholism
  • anxiety
  • breast-feeding
  • colitis
  • depression
  • diarrhea
  • geriatric
  • GI disease
  • inflammatory bowel disease
  • pregnancy
  • pseudomembranous colitis
  • psychosis
  • renal disease
  • renal failure
  • renal impairment
  • seizure disorder
  • ulcerative colitis

Interactions

  • Ethanol
  • Ethionamide
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Pyridoxine, Vitamin B6
  • Teriflunomide

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