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Cyclizine Brand Names- Cyclivert | Marezine
What is Cyclizine
Cyclizine is an oral, sedating H1 antagonist (antihistamine) with anticholinergic, antiemetic, and antivertigo properties.
Cyclizine is a piperazine derivative that is structurally related to buclizine, hydroxyzine, and meclizine. It is used to prevent and treat nausea, vomiting, and dizziness associated with motion sickness.
Some data indicate that cyclizine may be misused alone or in combination with other drugs with abuse potential (e.g., opiates) to produce an hallucinogenic effect.
Cyclizine (Marezine) was approved by the FDA in 1953.
Indications
- motion sickness
For over-the-counter (non-prescription) prevention and treatment of symptoms associated with motion sickness such as nausea, vomiting, and dizziness
Side Effects
- anorexia
- blurred vision
- constipation
- drowsiness
- dysuria
- euphoria
- excitability
- fatigue
- hallucinations
- hypotension
- nasal dryness
- palpitations
- restlessness
- sinus tachycardia
- urinary retention
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- asthma
- bladder obstruction
- breast-feeding
- bronchitis
- cardiac disease
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- contact lenses
- driving or operating machinery
- emphysema
- ethanol intoxication
- geriatric
- GI obstruction
- hepatic disease
- ileus
- infants
- neonates
- pregnancy
- premature neonates
- prostatic hypertrophy
- renal failure
- renal impairment
- urinary retention
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Alfentanil
- Alosetron
- Amantadine
- Ambenonium Chloride
- Amikacin
- Aminoglycosides
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Anticholinergics
- Aripiprazole
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Azelastine
- Azelastine; Fluticasone
- Baclofen
- Belladonna; Opium
- Benzodiazepines
- Benzphetamine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butorphanol
- Cannabidiol
- Capsaicin; Metaxalone
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carisoprodol
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorzoxazone
- Clobazam
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Dantrolene
- Daratumumab; Hyaluronidase
- Desloratadine
- Desloratadine; Pseudoephedrine
- Dexmedetomidine
- Dextroamphetamine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Dronabinol
- Entacapone
- Eszopiclone
- Ethanol
- Etomidate
- Fentanyl
- Flibanserin
- Fospropofol
- Gabapentin
- Galantamine
- Gentamicin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Halogenated Anesthetics
- Heparin
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen; Oxycodone
- Iloperidone
- Ipecac
- Isocarboxazid
- Kanamycin
- Ketamine
- Lasmiditan
- Lemborexant
- Levocetirizine
- Levomethadyl
- Levorphanol
- Lithium
- Loratadine
- Loratadine; Pseudoephedrine
- Loxapine
- Lurasidone
- Magnesium Salts
- Maprotiline
- Meclizine
- Melatonin
- Meperidine
- Meperidine; Promethazine
- Meprobamate
- Metaxalone
- Methadone
- Methamphetamine
- Methocarbamol
- Metoclopramide
- Metyrapone
- Metyrosine
- Minocycline
- Mirtazapine
- Mitotane
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nefazodone
- Opiate Agonists
- Orphenadrine
- Oxycodone
- Oxymorphone
- Paliperidone
- Paromomycin
- Pentazocine
- Pentazocine; Naloxone
- Perampanel
- Phenelzine
- Pitolisant
- Plazomicin
- Pramipexole
- Pregabalin
- Procarbazine
- Propofol
- Propoxyphene
- Ramelteon
- Rasagiline
- Remifentanil
- Risperidone
- Rituximab; Hyaluronidase
- Rivastigmine
- Ropinirole
- Safinamide
- Selegiline
- Sincalide
- Sodium Iodide
- Solifenacin
- Streptomycin
- Sufentanil
- Suvorexant
- Tacrine
- Tasimelteon
- Teniposide
- Thalidomide
- Thiothixene
- Tizanidine
- Tobramycin
- Tolcapone
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Trazodone
- Tricyclic antidepressants
- Trimethobenzamide
- Trospium
- Vigabatrin
- Vilazodone
- Zaleplon
- Ziconotide
- Zolpidem
