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Codeine Phenylephrine Promethazine Brand Names
Pentazine VC with Codeine | Prometh VC with Codeine
What is Codeine Phenylephrine Promethazine
Codeine phenylephrine promethazine are used together in an oral preparation to treat upper respiratory congestion, cough, and related symptoms.
Phenylephrine is a sympathomimetic agent that causes vasoconstriction and decreases nasal and sinus congestion.
Promethazine is a phenothiazine-related antihistamine that dries the nasal and sinus passages.
Codeine is an opiate agent with antitussive activity. Codeine is a prodrug that is hepatically metabolized to morphine. Codeine metabolism is highly variable and unpredictable, particularly in children younger than 12 years; therapeutic response to recommended doses can range from lack of effect in poor metabolizers to fatality in ultra-rapid metabolizers.
Opioid cough and cold medicines that contain codeine are not indicated in pediatric patients under 18 years of age.
These products are contraindicated in neonates, infants and children less than 12 years of age; risks of opioid-containing cough and cold medicines outweigh their benefits in patients younger than 18 years.
Codeine phenylephrine promethazine is also contraindicated in adolescent pediatric patients 12 to 18 years of age after tonsillectomy or adenoidectomy.
Indications
- common cold
- cough
- nasal congestion
For the temporary relief of cough and upper respiratory symptoms (e.g., nasal congestion) associated with allergy or the common cold
Side Effects
- agranulocytosis
- akathisia
- angina
- anxiety
- aplastic anemia
- apnea
- blurred vision
- bradycardia
- cholestasis
- coma
- confusion
- constipation
- contact dermatitis
- corneal opacification
- cyanosis
- dizziness
- drowsiness
- dyspnea
- dystonic reaction
- dysuria
- eosinophilia
- fatigue
- fever
- hallucinations
- headache
- heart failure
- hemolytic anemia
- hepatitis
- hyperglycemia
- hypertension
- hyperthermia
- hypotension
- hypothermia
- ileus
- impaired cognition
- impotence (erectile dysfunction)
- insomnia
- intracranial bleeding
- jaundice
- leukopenia
- miosis
- mydriasis
- myocardial infarction
- nausea
- neonatal opioid withdrawal syndrome
- neonatal respiratory depression
- neuroleptic malignant syndrome
- neutropenia
- orthostatic hypotension
- palpitations
- pancytopenia
- photosensitivity
- physiological dependence
- platelet dysfunction
- pseudoparkinsonism
- psychological dependence
- psychosis
- pulmonary edema
- purpura
- rash
- respiratory arrest
- respiratory depression
- restlessness
- retinopathy
- seizures
- skin hyperpigmentation
- tardive dyskinesia
- thrombocytopenia
- urinary retention
- ventricular tachycardia
- visual impairment
- vomiting
- weight gain
- withdrawal
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- accidental exposure
- acute abdomen
- acute myocardial infarction
- adenoidectomy
- adrenal insufficiency
- agranulocytosis
- alcoholism
- angina
- arteriosclerosis
- Asian patients
- asthma
- biliary tract disease
- Black patients
- bladder obstruction
- bone marrow suppression
- brain tumor
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- Caucasian patients
- cerebrovascular disease
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- coadministration with other CNS depressants
- coma
- constipation
- contact lenses
- cor pulmonale
- coronary artery disease
- dehydration
- dementia
- depression
- diabetes mellitus
- diarrhea
- driving or operating machinery
- dyskinesia
- ethanol ingestion
- ethanol intoxication
- gallbladder disease
- geriatric
- GI disease
- GI obstruction
- head trauma
- heart failure
- hepatic disease
- Hispanic patients
- hypertension
- hyperthyroidism
- hypotension
- hypothyroidism
- hypovolemia
- hypoxemia
- ileus
- increased intracranial pressure
- infants
- inflammatory bowel disease
- jaundice
- labor
- laboratory test interference
- MAOI therapy
- myocardial infarction
- myxedema
- neonatal opioid withdrawal syndrome
- neonates
- neuromuscular disease
- obesity
- obstetric delivery
- opiate agonist hypersensitivity
- orthostatic hypotension
- pancreatitis
- peripheral vascular disease
- phenothiazine hypersensitivity
- poor metabolizers
- potential for overdose or poisoning
- pregnancy
- prostatic hypertrophy
- pulmonary disease
- radiographic contrast administration
- renal failure
- renal impairment
- respiratory depression
- respiratory infection
- respiratory insufficiency
- Reye’s syndrome
- scoliosis
- seizure disorder
- seizures
- shock
- sleep apnea
- status asthmaticus
- substance abuse
- syncope
- tonsillectomy
- ulcerative colitis
- urethral stricture
- urinary retention
Interactions
- Abarelix
- Abiraterone
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetohexamide
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Aldesleukin, IL-2
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Almotriptan
- Alogliptin
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- Alogliptin; Pioglitazone
- Alosetron
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- Alprazolam
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- Amiloride
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- Aminoglycosides
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- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
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- Aspirin, ASA; Carisoprodol; Codeine
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- Brompheniramine; Pseudoephedrine
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- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
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- Chlordiazepoxide; Clidinium
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- Chloroquine
- Chlorothiazide
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorpropamide
- Chlorthalidone
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- Cimetidine
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- Ciprofloxacin
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- Clarithromycin
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- Clindamycin; Tretinoin
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- Clonazepam
- Clonidine
- Clopidogrel
- Clorazepate
- Clozapine
- Cobicistat
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Promethazine
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- Dapagliflozin; Metformin
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- Darifenacin
- Darunavir
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- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deflazacort
- Degarelix
- Delavirdine
- Desflurane
- Desipramine
- Desloratadine; Pseudoephedrine
- Desmopressin
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- Deutetrabenazine
- Dexamethasone
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexmethylphenidate
- Dexpanthenol
- Dextroamphetamine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Dicyclomine
- Diethylpropion
- Digitoxin
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
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- Dimenhydrinate
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- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
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- Disopyramide
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- Dolasetron
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- Doxylamine
- Doxylamine; Pyridoxine
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- Dronedarone
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- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dulaglutide
- Duloxetine
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- Dyphylline; Guaifenesin
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- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
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- Eluxadoline
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- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
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- Enalapril; Felodipine
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- Enflurane
- Entrectinib
- Enzalutamide
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- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
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- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
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- Ethosuximide
- Ethotoin
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- food
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- grapefruit juice
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- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Nesiritide, BNP
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nicardipine
- Nicotine
- Nifedipine
- Nilotinib
- Nimodipine
- Nisoldipine
- Nitrates
- Nitroglycerin
- Non-Ionic Contrast Media
- Norepinephrine
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Oritavancin
- Orphenadrine
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxazepam
- Oxybutynin
- Oxycodone
- Oxymorphone
- Oxytocin
- Ozanimod
- Palbociclib
- Paliperidone
- Palonosetron
- Panobinostat
- Papaverine
- Paromomycin
- Paroxetine
- Pasireotide
- Pazopanib
- Peginterferon Alfa-2b
- Pegvisomant
- Pemoline
- Penbutolol
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Pergolide
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenelzine
- Phenobarbital
- Phenothiazines
- Phenoxybenzamine
- Phentermine
- Phentermine; Topiramate
- Phentolamine
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Phosphodiesterase inhibitors
- Photosensitizing agents (topical)
- Pilocarpine
- Pimavanserin
- Pimozide
- Pindolol
- Pioglitazone
- Pirbuterol
- Pitolisant
- Plazomicin
- Porfimer
- Posaconazole
- Potassium-sparing diuretics
- Pramipexole
- Pramlintide
- Prasugrel
- Prazosin
- Prednisolone
- Prednisone
- Pregabalin
- Prilocaine
- Prilocaine; Epinephrine
- Primaquine
- Primidone
- Procainamide
- Procarbazine
- Prochlorperazine
- Propafenone
- Propantheline
- Propofol
- Propoxyphene
- Propranolol
- Protriptyline
- Pseudoephedrine
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Racepinephrine
- Ramelteon
- Ranolazine
- Rasagiline
- Remifentanil
- Reserpine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifamycins
- Rifapentine
- Rifaximin
- Rilpivirine
- Riociguat
- Risperidone
- Ritonavir
- Rivastigmine
- Rizatriptan
- Rolapitant
- Romidepsin
- Ropinirole
- Ropivacaine
- Rosiglitazone
- Rotigotine
- Rucaparib
- Safinamide
- Salmeterol
- Saquinavir
- Saxagliptin
- Scopolamine
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Selexipag
- Selpercatinib
- Semaglutide
- Serotonin-Receptor Agonists
- Serotonin-Receptor Antagonists
- Sertraline
- Sevoflurane
- SGLT2 Inhibitors
- Short-acting beta-agonists
- Sibutramine
- Sildenafil
- Simvastatin; Sitagliptin
- Siponimod
- Sitagliptin
- Skeletal Muscle Relaxants
- Sodium Oxybate
- Solifenacin
- Solriamfetol
- Sorafenib
- Sotalol
- Sparfloxacin
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Streptomycin
- Sufentanil
- Sulfonylureas
- Sumatriptan
- Sunitinib
- Suvorexant
- Tacrolimus
- Tadalafil
- Tamoxifen
- Tamsulosin
- Tapentadol
- Tasimelteon
- Tazarotene
- Tazemetostat
- Telavancin
- Telithromycin
- Telotristat Ethyl
- Temazepam
- Teniposide
- Terazosin
- Terbinafine
- Terbutaline
- Tetrabenazine
- Tetracaine
- Thalidomide
- Theophylline, Aminophylline
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thioridazine
- Thiothixene
- Thyroid hormones
- Tiagabine
- Ticagrelor
- Timolol
- Tipranavir
- Tizanidine
- tobacco
- Tobramycin
- Tolazamide
- Tolbutamide
- Tolterodine
- Topiramate
- Toremifene
- Torsemide
- Tramadol
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Tretinoin, ATRA
- Triamcinolone
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimethobenzamide
- Trimipramine
- Triprolidine
- Triptorelin
- Trospium
- Tucatinib
- Umeclidinium; Vilanterol
- Valerian, Valeriana officinalis
- Valproic Acid, Divalproex Sodium
- Vandetanib
- Vardenafil
- Vasodilators
- Vemurafenib
- Venlafaxine
- Verapamil
- Verteporfin
- Vigabatrin
- Vilazodone
- Voriconazole
- Vorinostat
- Vortioxetine
- Voxelotor
- Yohimbine
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolmitriptan
- Zolpidem
- Zonisamide
