Codeine Guaifenesin

Codeine Guaifenesin Brand Names

Allfen CD | Allfen CDX | Antituss AC | Brontex | Cheracol with Codeine | Cheratussin AC | Codefen | Dex-Tuss | Diabetic Tussin C | Duraganidin NR | ExeClear-C | Gani-Tuss NR | Guai Co | Guaiatussin AC | Guaifen C | Guiatuss AC | Halotussin AC | Iophen C-NR | Mar-Cof CG | M-Clear | M-Clear WC | Mytussin AC | Ninjacof-XG | RelCof C | Robafen AC | Romilar AC | Tussiden C | Tussi-Organidin NR | Tusso-C | Virtussin AC

What is Codeine Guaifenesin

Codeine guaifenesin are used together in oral preparations to relieve coughing due to minor throat and bronchial irritation as may occur with the common cold or inhaled irritants.

Codeine is an opiate agonist used as an antitussive agent. Codeine has a drying effect on respiratory tract mucosa and increases viscosity of bronchial secretions. Codeine also has mild analgesic and sedative effects. Guaifenesin loosens and thins phlegm and bronchial secretions to ease expectoration. Despite its long history of use since the 1950s, the efficacy of guaifenesin has only recently been substantiated.

Although guaifenesin may be used as an expectorant in both productive and non-productive coughs, it is especially useful in the treatment of dry, non-productive coughs which tend to injure the respiratory mucous membranes.

Codeine is a prodrug that is hepatically metabolized to morphine. Codeine metabolism is highly variable and unpredictable, particularly in children younger than 12 years; therapeutic response to recommended doses can range from lack of effect in poor metabolizers to fatality in ultra-rapid metabolizers.

Opioid cough and cold medicines that contain codeine are not indicated in pediatric patients under 18 years of age.

These products are contraindicated in neonates, infants and children less than 12 years of age; risks of opioid-containing cough and cold medicines outweigh their benefits in patients younger than 18 years.

Codeine guaifenesin is also contraindicated in adolescent pediatric patients 12 to 18 years of age after tonsillectomy or adenoidectomy.

Indications

• cough

For the temporary relief of nonproductive cough due to minor throat and bronchial irritation as may occur with the common cold, acute bronchitis, or inhaled irritants

Side Effects

1. abdominal pain
2. anaphylactoid reactions
3. angioedema
4. anxiety
5. bradycardia
6. cardiac arrest
7. coma
8. confusion
9. constipation
10. cyanosis
11. dizziness
12. drowsiness
13. dysphoria
14. dyspnea
15. euphoria
16. hallucinations
17. headache
18. hypotension
19. laryngeal edema
20. miosis
21. nausea
22. neonatal opioid withdrawal syndrome
23. neonatal respiratory depression
24. nephrolithiasis
25. oliguria
26. orthostatic hypotension
27. palpitations
28. physiological dependence
29. pruritus
30. psychological dependence
31. pulmonary edema
32. rash
33. respiratory arrest
34. respiratory depression
35. restlessness
36. seizures
37. sinus tachycardia
38. syncope
39. toxic megacolon
40. urinary retention
41. urticaria
42. visual impairment
43. vomiting
44. withdrawal

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• accidental exposure
• acute abdomen
• adenoidectomy
• adrenal insufficiency
• alcoholism
• Asian patients
• asthma
• biliary tract disease
• Black patients
• bladder obstruction
• brain tumor
• breast-feeding
• cardiac disease
• Caucasian patients
• children
• chronic obstructive pulmonary disease (COPD)
• coadministration with other CNS depressants
• coma
• constipation
• cor pulmonale
• dehydration
• depression
• diarrhea
• driving or operating machinery
• ethanol ingestion
• ethanol intoxication
• gallbladder disease
• geriatric
• GI disease
• GI obstruction
• head trauma
• hepatic disease
• Hispanic patients
• hypotension
• hypothyroidism
• hypovolemia
• hypoxemia
• ileus
• increased intracranial pressure
• infants
• inflammatory bowel disease
• labor
• laboratory test interference
• MAOI therapy
• myxedema
• neonatal opioid withdrawal syndrome
• neonates
• neuromuscular disease
• obesity
• obstetric delivery
• opiate agonist hypersensitivity
• orthostatic hypotension
• pancreatitis
• poor metabolizers
• potential for overdose or poisoning
• pregnancy
• prostatic hypertrophy
• pulmonary disease
• renal failure
• renal impairment
• respiratory depression
• respiratory infection
• respiratory insufficiency
• scoliosis
• seizure disorder
• seizures
• shock
• sleep apnea
• status asthmaticus
• substance abuse
• syncope
• tonsillectomy
• ulcerative colitis
• urethral stricture
• urinary retention

Interactions

• Abiraterone
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Diphenhydramine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Tramadol
• Acrivastine; Pseudoephedrine
• Aldesleukin, IL-2
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Almotriptan
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• Alvimopan
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• Amiodarone
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• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
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• Amoxicillin; Clarithromycin; Omeprazole
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• Aspirin, ASA; Caffeine; Orphenadrine
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• Aspirin, ASA; Carisoprodol; Codeine
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• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
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• Carbetapentane; Pyrilamine
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• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
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• Dexmedetomidine
• Dexpanthenol
• Dextromethorphan
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Diazepam
• Diltiazem
• Dimenhydrinate
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Dolasetron
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• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
• Dronedarone
• Droperidol
• Duloxetine
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• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elagolix
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• Eletriptan
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• Eluxadoline
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Enzalutamide
• Eprosartan; Hydrochlorothiazide, HCTZ
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Esketamine
• Eslicarbazepine
• Estazolam
• Eszopiclone
• Ethacrynic Acid
• Ethanol
• Ethotoin
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• Fluoxetine; Olanzapine
• Fluphenazine
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• Fosphenytoin
• Fospropofol
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• Frovatriptan
• Furosemide
• Gabapentin
• General anesthetics
• Givosiran
• Granisetron
• grapefruit juice
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guanabenz
• Guanfacine
• Haloperidol
• Halothane
• Homatropine; Hydrocodone
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hydroxyzine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Idelalisib
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