Codeine Dexchlorpheniramine Phenylephrine

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Codeine Dexchlorpheniramine Phenylephrine Brand Name– PRO-RED AC

What is Codeine Dexchlorpheniramine Phenylephrine

Codeine dexchlorpheniramine phenylephrine are used together in an oral preparation to treat upper respiratory congestion, coughing, and allergic rhinitis.

Phenylephrine is a sympathomimetic agent that causes vasoconstriction and decreases nasal and sinus congestion.

Dexchlorpheniramine is a sedating antihistamine (H1-blocker) that dries the nasal and sinus passages secondary to its anticholinergic activity. Codeine is an opiate agonist with antitussive activity. Codeine is a prodrug that is hepatically metabolized to morphine.

Codeine metabolism is highly variable and unpredictable, particularly in children younger than 12 years; therapeutic response to recommended doses can range from lack of effect in poor metabolizers to fatality in ultra-rapid metabolizers.

Opioid cough and cold medicines that contain codeine are not indicated in pediatric patients under 18 years of age.

These products are contraindicated in neonates, infants, and children less than 12 years of age; risks of opioid-containing cough and cold medicines outweigh their benefits in patients younger than 18 years.

Codeine dexchlorpheniramine phenylephrine is also contraindicated in adolescent pediatric patients 12 to 18 years of age after tonsillectomy or adenoidectomy.

Indications

  1. allergic rhinitis
  2. common cold
  3. cough
  4. sneezing

For the temporary relief of cough and upper respiratory symptoms (e.g., rhinorrhea, sneezing, itching of the nose or throat or itchy, watery eyes) associated with allergy (allergic rhinitis) or the common cold

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • accidental exposure
  • acute abdomen
  • acute myocardial infarction
  • adenoidectomy
  • adrenal insufficiency
  • alcoholism
  • angina
  • anticholinergic medications
  • arteriosclerosis
  • Asian patients
  • asthma
  • biliary tract disease
  • Black patients
  • bladder obstruction
  • brain tumor
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • Caucasian patients
  • cerebrovascular disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • coadministration with other CNS depressants
  • coma
  • constipation
  • contact lenses
  • cor pulmonale
  • coronary artery disease
  • dehydration
  • dementia
  • depression
  • diabetes mellitus
  • diarrhea
  • driving or operating machinery
  • ethanol ingestion
  • ethanol intoxication
  • gallbladder disease
  • geriatric
  • GI disease
  • GI obstruction
  • head trauma
  • heart failure
  • hepatic disease
  • Hispanic patients
  • hypertension
  • hyperthyroidism
  • hypotension
  • hypothyroidism
  • hypovolemia
  • hypoxemia
  • ileus
  • increased intracranial pressure
  • infants
  • inflammatory bowel disease
  • labor
  • MAOI therapy
  • myocardial infarction
  • myxedema
  • neonatal opioid withdrawal syndrome
  • neonates
  • neuromuscular disease
  • obesity
  • obstetric delivery
  • opiate agonist hypersensitivity
  • orthostatic hypotension
  • pancreatitis
  • peripheral vascular disease
  • poor metabolizers
  • potential for overdose or poisoning
  • pregnancy
  • prostatic hypertrophy
  • pulmonary disease
  • renal failure
  • renal impairment
  • respiratory depression
  • respiratory infection
  • respiratory insufficiency
  • scoliosis
  • seizure disorder
  • seizures
  • shock
  • sleep apnea
  • status asthmaticus
  • substance abuse
  • syncope
  • tonsillectomy
  • ulcerative colitis
  • urethral stricture
  • urinary retention

Interactions

  • Abiraterone
  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
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  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
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  • Propafenone
  • Propofol
  • Propoxyphene
  • Propranolol
  • Protriptyline
  • Pseudoephedrine
  • Quazepam
  • Quetiapine
  • Quinidine
  • Quinine
  • Racepinephrine
  • Ramelteon
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Reserpine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rifaximin
  • Riociguat
  • Risperidone
  • Ritonavir
  • Rituximab; Hyaluronidase
  • Rivastigmine
  • Rizatriptan
  • Rolapitant
  • Ropinirole
  • Ropivacaine
  • Rosiglitazone
  • Rotigotine
  • Rucaparib
  • Safinamide
  • Salmeterol
  • Saquinavir
  • Secobarbital
  • Selegiline
  • Selexipag
  • Selpercatinib
  • Semaglutide
  • Serotonin-Receptor Agonists
  • Serotonin-Receptor Antagonists
  • Sertraline
  • Sevoflurane
  • SGLT2 Inhibitors
  • Sibutramine
  • Sildenafil
  • Sincalide
  • Skeletal Muscle Relaxants
  • Sodium Iodide
  • Sodium Oxybate
  • Solifenacin
  • Solriamfetol
  • Sotalol
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Streptogramins
  • Sufentanil
  • Sulfonylureas
  • Sumatriptan
  • Suvorexant
  • Tacrine
  • Tadalafil
  • Tapentadol
  • Tasimelteon
  • Tazemetostat
  • Telithromycin
  • Telotristat Ethyl
  • Temazepam
  • Terazosin
  • Terbinafine
  • Terbutaline
  • Tetrabenazine
  • Tetracaine
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Thyroid hormones
  • Ticagrelor
  • Timolol
  • Tipranavir
  • Tizanidine
  • Tolcapone
  • Tolterodine
  • Torsemide
  • Tramadol
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Treprostinil
  • Triamcinolone
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimethobenzamide
  • Trimipramine
  • Triprolidine
  • Trospium
  • Tucatinib
  • Umeclidinium; Vilanterol
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Vardenafil
  • Vasodilators
  • Venlafaxine
  • Verapamil
  • Vigabatrin
  • Vilazodone
  • Voriconazole
  • Vortioxetine
  • Voxelotor
  • Yohimbine
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem

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