Chlorpheniramine Dihydrocodeine; Phenylephrine

Chlorpheniramine Dihydrocodeine; Phenylephrine Brand Names

Baltussin | ColdCough PD | DiHydro-PE | Duohist DH | Novahistine DH | Pancof PD | Tusscough DHC

What is Chlorpheniramine Dihydrocodeine; Phenylephrine

Chlorpheniramine dihydrocodeine phenylephrine are used together in an oral preparation that is marketed to control cough and provide for temporary relief from congestion associated with the upper respiratory tract.

Chlorpheniramine is a sedating antihistamine (H1-blocker) of the alkylamine class. Dihydrocodeine is an opiate antitussive used for cough suppression. It is structurally related to codeine and has similar pharmacologic activity and complex metabolism.

Dihydrocodeine metabolism is highly variable and unpredictable, particularly in children younger than 12 years; therapeutic response to recommended doses can range from lack of effect in poor metabolizers to fatality in ultra-rapid metabolizers.

Phenylephrine is a sympathomimetic agent that relieves nasal and sinus congestion.

Chlorpheniramine dihydrocodeine phenylephrine formulations are available by prescription only; however, cough/cold products that contain dihydrocodeine have not been evaluated by the FDA for safety and efficacy, and many products are no longer marketed since they are considered unapproved drugs in the U.S.

Opioid cough and cold medicines that contain dihydrocodeine are not indicated in pediatric patients under 18 years of age.

These products are contraindicated in neonates, infants and children less than 12 years of age; risks of opioid-containing cough and cold medicines outweigh their benefits in patients younger than 18 years.

Chlorpheniramine dihydrocodeine phenylephrine is also contraindicated in adolescent pediatric patients 12 to 18 years of age after tonsillectomy or adenoidectomy

Indications

1. allergic rhinitis
2. common cold
3. cough
4. nasal congestion

For the temporary relief of cough and nasal congestion associated with upper respiratory tract infections (e.g., common cold) and allergies (i.e., allergic rhinitis)

Side Effects

1. abdominal pain
2. agranulocytosis
3. anaphylactoid reactions
4. angina
5. anorexia
6. anxiety
7. aplastic anemia
8. arrhythmia exacerbation
9. ataxia
10. blurred vision
11. colitis
12. confusion
13. constipation
14. contact dermatitis
15. cyanosis
16. diarrhea
17. dizziness
18. drowsiness
19. dyspepsia
20. dyspnea
21. dysuria
22. erythema
23. fatigue
24. flushing
25. hallucinations
26. headache
27. impaired cognition
28. increased intracranial pressure
29. insomnia
30. interstitial nephritis
31. irritability
32. myocardial infarction
33. nausea
34. neonatal opioid withdrawal syndrome
35. neonatal respiratory depression
36. ocular hypertension
37. photophobia
38. physiological dependence
39. premature ventricular contractions (PVCs)
40. pruritus
41. psychological dependence
42. psychosis
43. pulmonary edema
44. rash
45. renal failure (unspecified)
46. respiratory arrest
47. respiratory depression
48. restlessness
49. seizures
50. sinus tachycardia
51. stroke
52. supraventricular tachycardia (SVT)
53. thrombocytopenia
54. urinary retention
55. vomiting
56. weakness
57. withdrawal
58. xerophthalmia
59. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• accidental exposure
• acute abdomen
• acute myocardial infarction
• adenoidectomy
• adrenal insufficiency
• alcoholism
• angina
• Asian patients
• asthma
• biliary tract disease
• Black patients
• bladder obstruction
• brain tumor
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• Caucasian patients
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• coadministration with other CNS depressants
• coma
• constipation
• contact lenses
• cor pulmonale
• coronary artery disease
• dehydration
• depression
• diabetes mellitus
• diarrhea
• driving or operating machinery
• ethanol ingestion
• ethanol intoxication
• gallbladder disease
• geriatric
• GI disease
• GI obstruction
• head trauma
• hepatic disease
• Hispanic patients
• hypertension
• hyperthyroidism
• hypotension
• hypothyroidism
• hypovolemia
• hypoxemia
• ileus
• increased intracranial pressure
• infants
• inflammatory bowel disease
• labor
• MAOI therapy
• myocardial infarction
• myxedema
• neonatal opioid withdrawal syndrome
• neonates
• neuromuscular disease
• obesity
• obstetric delivery
• opiate agonist hypersensitivity
• orthostatic hypotension
• pancreatitis
• peripheral vascular disease
• poor metabolizers
• potential for overdose or poisoning
• pregnancy
• prostatic hypertrophy
• pulmonary disease
• renal failure
• renal impairment
• respiratory depression
• respiratory infection
• respiratory insufficiency
• scoliosis
• seizure disorder
• seizures
• shock
• sleep apnea
• status asthmaticus
• substance abuse
• syncope
• tonsillectomy
• ulcerative colitis
• urethral stricture
• urinary retention

Interactions

• Abiraterone
• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aldesleukin, IL-2
• Alfentanil
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Almotriptan
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alosetron
• Alpha-blockers
• Alpha-glucosidase Inhibitors
• Alprazolam
• Alvimopan
• Amantadine
• Ambenonium Chloride
• Ambrisentan
• Amide local anesthetics
• Amifampridine
• Amikacin
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminoglycosides
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amoxapine
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Anticholinergics
• Apalutamide
• Apomorphine
• Apraclonidine
• Aprepitant, Fosaprepitant
• Arformoterol
• Aripiprazole
• Armodafinil
• Artemether; Lumefantrine
• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atazanavir
• Atazanavir; Cobicistat
• Atenolol
• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Avanafil
• Azelastine
• Azelastine; Fluticasone
• Azilsartan; Chlorthalidone
• Baclofen
• Barbiturates
• Beclomethasone
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Benzodiazepines
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzphetamine
• Benztropine
• Beta-blockers
• Betamethasone
• Betaxolol
• Bethanechol
• Bexarotene
• Bicalutamide
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bosentan
• Bretylium
• Brexpiprazole
• Brigatinib
• Brimonidine
• Brimonidine; Brinzolamide
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Budesonide
• Budesonide; Formoterol
• Bumetanide
• Bupivacaine
• Bupivacaine Liposomal
• Bupivacaine; Lidocaine
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Caffeine
• Caffeine; Ergotamine
• Calcium-channel blockers
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Cannabidiol
• Capsaicin; Metaxalone
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cardiac glycosides
• Cariprazine
• Carisoprodol
• Carteolol
• Carvedilol
• Celecoxib
• Cenobamate
• Ceritinib
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chlophedianol; Dexbrompheniramine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chloral Hydrate
• Chloramphenicol
• Chlorcyclizine
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chloroprocaine
• Chlorothiazide
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpromazine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Ciclesonide
• Cimetidine
• Cinacalcet
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clemastine
• Clevidipine
• Clobazam
• Clomipramine
• Clonazepam
• Clonidine
• Clopidogrel
• Clorazepate
• Clozapine
• Cobicistat
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Colchicine
• Colchicine; Probenecid
• COMT inhibitors
• Conivaptan
• Corticosteroids
• Cortisone
• Crizotinib
• Crofelemer
• Cyclizine
• Cyclobenzaprine
• Cyclosporine
• Cyproheptadine
• Dabrafenib
• Dacomitinib
• Dalfopristin; Quinupristin
• Danazol
• Dantrolene
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Daratumumab; Hyaluronidase
• Darifenacin
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Deferasirox
• Deflazacort
• Delavirdine
• Desflurane
• Desipramine
• Desloratadine
• Desloratadine; Pseudoephedrine
• Desmopressin
• Desvenlafaxine
• Deutetrabenazine
• Dexamethasone
• Dexchlorpheniramine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmedetomidine
• Dexmethylphenidate
• Dexpanthenol
• Dextroamphetamine
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Diazepam
• Dicyclomine
• Diethylpropion
• Digitoxin
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Dihydroergotamine
• Diltiazem
• Dimenhydrinate
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Disopyramide
• Dolasetron
• Donepezil
• Donepezil; Memantine
• Dorzolamide; Timolol
• Doxazosin
• Doxepin
• Doxorubicin
• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
• Dronedarone
• Droperidol
• Dulaglutide
• Duloxetine
• Dutasteride; Tamsulosin
• Duvelisib
• Dyphylline
• Dyphylline; Guaifenesin
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elagolix
• Elagolix; Estradiol; Norethindrone acetate
• Elbasvir; Grazoprevir
• Eletriptan
• Elexacaftor; tezacaftor; ivacaftor
• Eliglustat
• Eltrombopag
• Eluxadoline
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Encorafenib
• Enflurane
• Entacapone
• Enzalutamide
• Epinephrine
• Epoprostenol
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ergoloid Mesylates
• Ergonovine
• Ergot alkaloids
• Ergotamine
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Esketamine
• Eslicarbazepine
• Esmolol
• Estazolam
• Eszopiclone
• Ethacrynic Acid
• Ethanol
• Etomidate
• Etravirine
• Everolimus
• Exenatide
• Ezogabine
• Fedratinib
• Felodipine
• Fentanyl
• Fesoterodine
• Fexofenadine; Pseudoephedrine
• Flavoxate
• Flibanserin
• Fluconazole
• Fludrocortisone
• Flunisolide
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Flurazepam
• Fluticasone
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• Formoterol
• Formoterol; Mometasone
• Fosamprenavir
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Fospropofol
• Fostamatinib
• Frovatriptan
• Furosemide
• Gabapentin
• Galantamine
• General anesthetics
• Gentamicin
• Ginger, Zingiber officinale
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate
• Glycopyrrolate; Formoterol
• Granisetron
• grapefruit juice
• Green Tea
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Pseudoephedrine
• Guanabenz
• Guanfacine
• Halofantrine
• Halogenated Anesthetics
• Haloperidol
• Halothane
• Heparin
• Homatropine; Hydrocodone
• Hyaluronidase
• Hyaluronidase, Recombinant; Immune Globulin
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydrocortisone
• Hydromorphone
• Hydroxyzine
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Ibuprofen; Pseudoephedrine
• Idelalisib
• Iloperidone
• Iloprost
• Imatinib
• Imipramine
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Indinavir
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Iobenguane I 131
• Ionic Contrast Media
• Isavuconazonium
• Isocarboxazid
• Isoflurane
• Isoniazid, INH
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isradipine
• Istradefylline
• Itraconazole
• Ivacaftor
• Kanamycin
• Ketamine
• Ketoconazole
• Labetalol
• Lapatinib
• Larotrectinib
• Lasmiditan
• Lefamulin
• Lemborexant
• Lesinurad
• Lesinurad; Allopurinol
• Letermovir
• Levalbuterol
• Levobetaxolol
• Levobunolol
• Levobupivacaine
• Levocetirizine
• Levomethadyl
• Levorphanol
• Levothyroxine
• Levothyroxine; Liothyronine (Porcine)
• Levothyroxine; Liothyronine (Synthetic)
• Lidocaine
• Lidocaine; Prilocaine
• Linagliptin; Metformin
• Lincosamides
• Linezolid
• Liothyronine
• Liraglutide
• Lithium
• Lixisenatide
• Lofexidine
• Loop diuretics
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Loratadine
• Loratadine; Pseudoephedrine
• Lorazepam
• Lorcaserin
• Lorlatinib
• Loxapine
• Lumacaftor; Ivacaftor
• Lumacaftor; Ivacaftor
• Lumateperone
• Lurasidone
• Macitentan
• Magnesium Salts
• Maprotiline
• Mecamylamine
• Meclizine
• Meglitinides
• Melatonin
• Mepenzolate
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Mepivacaine
• Mepivacaine; Levonordefrin
• Meprobamate
• Metaproterenol
• Metaxalone
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methamphetamine
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methocarbamol
• Methohexital
• Methscopolamine
• Methyclothiazide
• Methyldopa
• Methylene Blue
• Methylergonovine
• Methylphenidate
• Methylprednisolone
• Methysergide
• Metoclopramide
• Metolazone
• Metoprolol
• Metyrapone
• Metyrosine
• Midazolam
• Midodrine
• Mifepristone
• Miglitol
• Minocycline
• Mirabegron
• Mirtazapine
• Mitotane
• Modafinil
• Molindone
• Mometasone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nadolol
• Nafarelin
• Nafcillin
• Nalbuphine
• Naloxone
• Naltrexone
• Naproxen; Pseudoephedrine
• Naproxen; Sumatriptan
• Naratriptan
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Nelfinavir
• Nesiritide, BNP
• Netupitant, Fosnetupitant; Palonosetron
• Nevirapine
• Nicardipine
• Nicotine
• Nifedipine
• Nilotinib
• Nimodipine
• Nisoldipine
• Nitrates
• Nitroglycerin
• Non-Ionic Contrast Media
• Nortriptyline
• Octreotide
• Olanzapine
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Amoxicillin; Rifabutin
• Ondansetron
• Opiate Agonists
• Oritavancin
• Orphenadrine
• Osilodrostat
• Oxazepam
• Oxcarbazepine
• Oxybutynin
• Oxycodone
• Oxymorphone
• Oxytocin
• Ozanimod
• Palbociclib
• Paliperidone
• Palonosetron
• Panobinostat
• Papaverine
• Paromomycin
• Paroxetine
• Pazopanib
• Peginterferon Alfa-2b
• Pegvisomant
• Penbutolol
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Pergolide
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Phendimetrazine
• Phenelzine
• Phenobarbital
• Phenothiazines
• Phenoxybenzamine
• Phentermine
• Phentermine; Topiramate
• Phentolamine
• Phenylephrine; Promethazine
• Phenytoin
• Phosphodiesterase inhibitors
• Pimozide
• Pindolol
• Pioglitazone
• Pirbuterol
• Pitolisant
• Plazomicin
• Posaconazole
• Potassium-sparing diuretics
• Pramipexole
• Pramlintide
• Prasugrel
• Prazosin
• Prednisolone
• Prednisone
• Pregabalin
• Prilocaine
• Prilocaine; Epinephrine
• Primidone
• Procaine
• Procarbazine
• Prochlorperazine
• Promethazine
• Propafenone
• Propantheline
• Propofol
• Propoxyphene
• Propranolol
• Protriptyline
• Pseudoephedrine
• Quazepam
• Quetiapine
• Quinidine
• Quinine
• Racepinephrine
• Ramelteon
• Ranolazine
• Rasagiline
• Remifentanil
• Reserpine
• Ribociclib
• Ribociclib; Letrozole
• Rifabutin
• Rifampin
• Rifamycins
• Rifapentine
• Rifaximin
• Riociguat
• Risperidone
• Ritonavir
• Rituximab; Hyaluronidase
• Rivastigmine
• Rizatriptan
• Rolapitant
• Ropinirole
• Ropivacaine
• Rosiglitazone
• Rotigotine
• Rucaparib
• Safinamide
• Salmeterol
• Saquinavir
• Scopolamine
• Secobarbital
• Selegiline
• Selexipag
• Selpercatinib
• Semaglutide
• Serotonin-Receptor Agonists
• Serotonin-Receptor Antagonists
• Sertraline
• Sevoflurane
• SGLT2 Inhibitors
• Sibutramine
• Sildenafil
• Sincalide
• Skeletal Muscle Relaxants
• Sodium Iodide
• Sodium Oxybate
• Solifenacin
• Solriamfetol
• Sotalol
• Spironolactone
• St. John’s Wort, Hypericum perforatum
• Streptogramins
• Streptomycin
• Sufentanil
• Sulfonylureas
• Sumatriptan
• Suvorexant
• Tacrine
• Tadalafil
• Tamsulosin
• Tapentadol
• Tasimelteon
• Telithromycin
• Telotristat Ethyl
• Temazepam
• Terazosin
• Terbinafine
• Terbutaline
• Tetrabenazine
• Tetracaine
• Tezacaftor; Ivacaftor
• Thalidomide
• Theophylline, Aminophylline
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thioridazine
• Thiothixene
• Thyroid hormones
• Ticagrelor
• Timolol
• Tipranavir
• Tizanidine
• Tobramycin
• Tolcapone
• Tolterodine
• Topiramate
• Torsemide
• Tramadol
• Trandolapril; Verapamil
• Tranylcypromine
• Trastuzumab; Hyaluronidase
• Trazodone
• Treprostinil
• Triamcinolone
• Triamterene
• Triazolam
• Tricyclic antidepressants
• Trifluoperazine
• Trihexyphenidyl
• Trimethobenzamide
• Trimipramine
• Triprolidine
• Trospium
• Tucatinib
• Umeclidinium; Vilanterol
• Valerian, Valeriana officinalis
• Valproic Acid, Divalproex Sodium
• Vardenafil
• Vasodilators
• Vemurafenib
• Venlafaxine
• Verapamil
• Vigabatrin
• Vilazodone
• Voriconazole
• Vortioxetine
• Yohimbine
• Zafirlukast
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolmitriptan
• Zolpidem