Chloroxylenol Hydrocortisone Pramoxine

Chloroxylenol Hydrocortisone Pramoxine Brand Names

Aero Otic HC | Cortamox | Cortane B | Cortic | Cortic ND | Cyotic | Exotic-HC | IvDerm | Mediotic-HC | OtiRx | Oto-End | Otomar | Otomar-HC | Otozone | Pramoxine-HC | RE Pramoxine-HC | Tri-Otic | Zolene-HC | Zotane-HC | Zoto-HC

What is Chloroxylenol Hydrocortisone Pramoxine

Chloroxylenol hydrocortisone pramoxine otic preparations are used topically in the ear for the treatment of susceptible superficial ear infections of the external auditory canal (otitis externa).

Chloroxylenol is an antiseptic agent; hydrocortisone is a glucocorticoid that has antiinflammatory, antipruritic, and vasoconstrictive properties; pramoxine is a topical anesthetic that provides relief of pain and itching.

Chloroxylenol hydrocortisone pramoxine otic combinations have been in clinical use for decades.


  • otitis externa

For the treatment of uncomplicated acute otitis externa

Side Effects

  1. acneiform rash
  2. folliculitis
  3. hypertrichosis
  4. pruritus
  5. skin hypopigmentation
  6. skin irritation
  7. xerosis

Hypersensitivity and other adverse reactions to chloroxylenol; hydrocortisone; pramoxine otic combinations are rare.

Discontinue treatment if signs and symptoms of a local allergic reaction occur.

The following adverse reactions with topical corticosteroids have been observed: pruritus, burning, skin irritation, dryness (xerosis), folliculitis, hypertrichosis, acneiform rash and skin hypopigmentation.

Systemic adverse effects of the corticosteroid could occur with prolonged or excessive use; avoid use beyond recommended treatment durations.

Monitoring Parameters

  • laboratory monitoring not necessary


  • breast-feeding
  • children
  • ear discharge
  • herpes infection
  • infants
  • ophthalmic administration
  • otitis media
  • pregnancy
  • tympanic membrane perforation
  • varicella


  • Adapalene; Benzoyl Peroxide
  • Benzocaine
  • Benzocaine; Butamben; Tetracaine
  • Benzoyl Peroxide
  • Benzoyl Peroxide; Clindamycin
  • Benzoyl Peroxide; Erythromycin
  • Benzoyl Peroxide; Sulfur
  • Dibucaine
  • Ethyl Chloride
  • Hydrocortisone; Lidocaine
  • Lidocaine
  • Lidocaine; Prilocaine
  • Lidocaine; Tetracaine
  • Tetracaine

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