Acyclovir and Hydrocortisone

Acyclovir and Hydrocortisone Brand Name– Xerese

What is Acyclovir and Hydrocortisone

Acyclovir and hydrocortisone is a topical agent for the treatment of herpes labialis (cold sores).

Acyclovir is an antiviral agent and is a synthetic nucleoside analogue that has inhibitory activity against herpes viruses (herpes simplex virus type 1, HSV-1, and herpes simplex virus type 2, HSV-2).

The inhibitory activity is highly selective due to acyclovir’s affinity for the thymidine kinase enzyme encoded by HSV. Hydrocortisone is a steroid hormone secreted by the adrenal cortex.

Topically, hydrocortisone is used for its anti-inflammatory effects.

Topical acyclovir and hydrocortisone was approved by the FDA in July 2009 for the treatment of recurrent herpes labialis.

Indications

  1. herpes labialis
  2. herpes simplex virus type 1
  3. herpes simplex virus type 2

Side Effects

  1. contact dermatitis
  2. erythema
  3. skin irritation
  4. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • children
  • fungal infection
  • geriatric
  • immunosuppression
  • infants
  • neonates
  • ophthalmic administration
  • pregnancy

Interactions

There are no drug interactions associated with Acyclovir; Hydrocortisone products.

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