Acyclovir and Hydrocortisone Brand Name– Xerese
What is Acyclovir and Hydrocortisone
Acyclovir and hydrocortisone is a topical agent for the treatment of herpes labialis (cold sores).
Acyclovir is an antiviral agent and is a synthetic nucleoside analogue that has inhibitory activity against herpes viruses (herpes simplex virus type 1, HSV-1, and herpes simplex virus type 2, HSV-2).
The inhibitory activity is highly selective due to acyclovir’s affinity for the thymidine kinase enzyme encoded by HSV. Hydrocortisone is a steroid hormone secreted by the adrenal cortex.
Topically, hydrocortisone is used for its anti-inflammatory effects.
Topical acyclovir and hydrocortisone was approved by the FDA in July 2009 for the treatment of recurrent herpes labialis.
Indications
- herpes labialis
- herpes simplex virus type 1
- herpes simplex virus type 2
Side Effects
- contact dermatitis
- erythema
- skin irritation
- xerosis
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- children
- fungal infection
- geriatric
- immunosuppression
- infants
- neonates
- ophthalmic administration
- pregnancy
Interactions
There are no drug interactions associated with Acyclovir; Hydrocortisone products.