Ceftazidime Avibactam

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Ceftazidime Avibactam Brand Name– AVYCAZ

What is Ceftazidime Avibactam

Ceftazidime avibactam is a combination product consisting of a third-generation cephalosporin and a beta-lactamase inhibitor.

The drug is indicated for the treatment of complicated intra-abdominal infections (when used in combination with metronidazole) and complicated urinary tract infections in adult and pediatric patients 3 months and older.

It is also indicated for hospital-acquired and ventilator-associated pneumonia (HAP/VAP) in adult patients.

Approval was based on the results of several randomized phase 2 and phase 3 studies and on previous findings regarding safety and efficacy of ceftazidime.

Decreased efficacy was seen in adult patients with complicated intra-abdominal infections and baseline CrCl 30 to 50 mL/minute during clinical trials; monitor renal function daily in all patients with changing renal function with dose adjustment as needed.

Indications

  1. Citrobacter freundii
  2. Citrobacter koseri
  3. Enterobacter cloacae
  4. Escherichia coli
  5. Haemophilus influenzae (beta-lactamase negative)
  6. Haemophilus influenzae (beta-lactamase positive)
  7. intraabdominal infections
  8. Klebsiella aerogenes
  9. Klebsiella oxytoca
  10. Klebsiella pneumoniae
  11. Morganella morganii
  12. nosocomial pneumonia
  13. Proteus mirabilis
  14. Providencia rettgeri
  15. Providencia stuartii
  16. Pseudomonas aeruginosa
  17. pyelonephritis
  18. sepsis
  19. Serratia marcescens
  20. urinary tract infection (UTI)

Side Effects

  1. abdominal pain
  2. anxiety
  3. asterixis
  4. candidiasis
  5. coma
  6. constipation
  7. diarrhea
  8. dizziness
  9. dysgeusia
  10. elevated hepatic enzymes
  11. encephalopathy
  12. headache
  13. hypokalemia
  14. leukopenia
  15. maculopapular rash
  16. myoclonia
  17. nausea
  18. nephrolithiasis
  19. phlebitis
  20. pruritus
  21. pseudomembranous colitis
  22. rash
  23. renal failure (unspecified)
  24. seizures
  25. superinfection
  26. thrombocytopenia
  27. thrombocytosis
  28. urticaria
  29. vomiting

Monitoring Parameters

  • CBC with differential
  • serum creatinine

Contraindications

  • breast-feeding
  • carbapenem hypersensitivity
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • coma
  • diarrhea
  • encephalopathy
  • GI disease
  • inflammatory bowel disease
  • laboratory test interference
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • seizures
  • serious rash
  • ulcerative colitis
  • vitamin K deficiency

Interactions

  • Amikacin
  • Aminoglycosides
  • Colchicine; Probenecid
  • Gentamicin
  • Kanamycin
  • Loop diuretics
  • Oral Contraceptives
  • Paromomycin
  • Plazomicin
  • Probenecid
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Streptomycin
  • Tobramycin
  • Warfarin

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