Ceftazidime Avibactam Brand Name– AVYCAZ
What is Ceftazidime Avibactam
Ceftazidime avibactam is a combination product consisting of a third-generation cephalosporin and a beta-lactamase inhibitor.
The drug is indicated for the treatment of complicated intra-abdominal infections (when used in combination with metronidazole) and complicated urinary tract infections in adult and pediatric patients 3 months and older.
It is also indicated for hospital-acquired and ventilator-associated pneumonia (HAP/VAP) in adult patients.
Approval was based on the results of several randomized phase 2 and phase 3 studies and on previous findings regarding safety and efficacy of ceftazidime.
Decreased efficacy was seen in adult patients with complicated intra-abdominal infections and baseline CrCl 30 to 50 mL/minute during clinical trials; monitor renal function daily in all patients with changing renal function with dose adjustment as needed.
Indications
- Citrobacter freundii
- Citrobacter koseri
- Enterobacter cloacae
- Escherichia coli
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- intraabdominal infections
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Morganella morganii
- nosocomial pneumonia
- Proteus mirabilis
- Providencia rettgeri
- Providencia stuartii
- Pseudomonas aeruginosa
- pyelonephritis
- sepsis
- Serratia marcescens
- urinary tract infection (UTI)
Side Effects
- abdominal pain
- anxiety
- asterixis
- candidiasis
- coma
- constipation
- diarrhea
- dizziness
- dysgeusia
- elevated hepatic enzymes
- encephalopathy
- headache
- hypokalemia
- leukopenia
- maculopapular rash
- myoclonia
- nausea
- nephrolithiasis
- phlebitis
- pruritus
- pseudomembranous colitis
- rash
- renal failure (unspecified)
- seizures
- superinfection
- thrombocytopenia
- thrombocytosis
- urticaria
- vomiting
Monitoring Parameters
- CBC with differential
- serum creatinine
Contraindications
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- coagulopathy
- colitis
- coma
- diarrhea
- encephalopathy
- GI disease
- inflammatory bowel disease
- laboratory test interference
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- seizures
- serious rash
- ulcerative colitis
- vitamin K deficiency
Interactions
- Amikacin
- Aminoglycosides
- Colchicine; Probenecid
- Gentamicin
- Kanamycin
- Loop diuretics
- Oral Contraceptives
- Paromomycin
- Plazomicin
- Probenecid
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Streptomycin
- Tobramycin
- Warfarin
