Cefdinir

Cefdinir Brand Name– Omnicef

What is Cefdinir

Cefdinir (FK482, CI—983) is an oral extended-spectrum, semisynthetic, cephalosporin. It is generally classified as a third generation cephalosporin with activity similar to cefotaxime and cefixime.

In a comparison to cefixime, cefpodoxime, cefaclor, and cephalexin in vitro, cefdinir is more active against oxacillin-sensitive Staphylcoccus aureus and coagulase-negative staphylococci, Streptococcus pneumoniae, S. pyogens, Escherichia coli, and Moraxella catarrhalis. Cefdinir is less active than cefixime against Hemophilus influenzae, Klebsiella pneumonia, K. oxytoca, Proteus mirabilis and P. vulgaris.

Cefdinir is not active against methicillin-resistant staphylococci or Pseudomonas aeruginosa.

A post-antibiotic effect of cefdinir has been shown against S. aureus and S. pyogens but not against E. coli or K. pneumonia. Cefdinir is approved for treatment of skin infections and a variety of upper respiratory infections including chronic bronchitis, otitis media, pharyngitis, pneumonia, sinusitis, and tonsillitis in both adult and pediatric patients.

It is available in both capsules and in a strawberry-flavored suspension.

Final FDA approval was granted December 8, 1997.

Indications

  1. bronchitis
  2. Citrobacter koseri
  3. community-acquired pneumonia
  4. Escherichia coli
  5. Haemophilus influenzae (beta-lactamase negative)
  6. Haemophilus influenzae (beta-lactamase positive)
  7. Haemophilus parainfluenzae
  8. Klebsiella pneumoniae
  9. Moraxella catarrhalis
  10. otitis media
  11. pharyngitis
  12. pneumonia
  13. Proteus mirabilis
  14. sinusitis
  15. skin and skin structure infections
  16. Staphylococcus aureus (MSSA)
  17. Staphylococcus epidermidis
  18. Streptococcus agalactiae (group B streptococci)
  19. Streptococcus pneumoniae
  20. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  21. tonsillitis
  22. urinary tract infection (UTI)
  23. Viridans streptococci

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. angioedema
  6. anorexia
  7. aplastic anemia
  8. asthenia
  9. azotemia
  10. bleeding
  11. candidiasis
  12. chest pain (unspecified)
  13. cholestasis
  14. colitis
  15. conjunctivitis
  16. constipation
  17. diarrhea
  18. disseminated intravascular coagulation (DIC)
  19. dizziness
  20. drowsiness
  21. dyspepsia
  22. elevated hepatic enzymes
  23. eosinophilia
  24. eosinophilic pneumonia
  25. erythema multiforme
  26. erythema nodosum
  27. exfoliative dermatitis
  28. fever
  29. flatulence
  30. GI bleeding
  31. glycosuria
  32. headache
  33. heart failure
  34. hematuria
  35. hemolytic anemia
  36. hepatic failure
  37. hepatitis
  38. hyperamylasemia
  39. hyperbilirubinemia
  40. hyperglycemia
  41. hyperkalemia
  42. hyperkinesis
  43. hyperphosphatemia
  44. hypertension
  45. hypocalcemia
  46. hypophosphatemia
  47. ileus
  48. insomnia
  49. involuntary movements
  50. jaundice
  51. laryngeal edema
  52. leukopenia
  53. leukorrhea
  54. maculopapular rash
  55. melena
  56. myocardial infarction
  57. nausea
  58. neutropenia
  59. pancytopenia
  60. peptic ulcer
  61. proteinuria
  62. pruritus
  63. pseudomembranous colitis
  64. rash
  65. renal failure (unspecified)
  66. respiratory arrest
  67. rhabdomyolysis
  68. seizures
  69. serum sickness
  70. Stevens-Johnson syndrome
  71. stomatitis
  72. stool discoloration
  73. superinfection
  74. thrombocytopenia
  75. thrombotic thrombocytopenic purpura (TTP)
  76. toxic epidermal necrolysis
  77. vaginitis
  78. vasculitis
  79. vomiting
  80. xerostomia

Monitoring Parameters

  • prothrombin time (PT)
  • serum creatinine/BUN

Contraindications

  • antimicrobial resistance
  • breast-feeding
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • diabetes mellitus
  • dialysis
  • diarrhea
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • neonates
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • ulcerative colitis
  • viral infection
  • vitamin K deficiency

Interactions

  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Antacids
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Choline Salicylate; Magnesium Salicylate
  • Dienogest; Estradiol valerate
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Iron
  • Iron Salts
  • Lanthanum Carbonate
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Loop diuretics
  • Magnesium Salicylate
  • Magnesium Salts
  • Mestranol; Norethindrone
  • Norethindrone
  • Norgestrel
  • Oral Contraceptives
  • Polysaccharide-Iron Complex
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Warfarin
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