Cefditoren

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Cefditoren Brand Name– Spectracef

What is Cefditoren

Cefditoren pivoxil (also known as ME-1206) is an oral prodrug for cefditoren. Cefditoren is a semi-synthetic, broad-spectrum, third generation cephalosporin that is a very potent oral beta-lactam antibiotic.

It is active against both beta-lactamase negative and positive Haemophilus influenzae, but is not active against Pseudomonas aeruginosaStenotrophomonas maltophiliaAcinetobacter, and other non-fermentors. Cefditoren activity against Staphylococci is comparable to that of oxacillin.

It is also very active against Escherichia coliKlebsiella spp, Proteus mirabilis, and Salmonella spp.

Cefditoren was studied in over 6000 adult and adolescent patients in clinical trials and is approved for the treatment of pharyngitis, tonsillitis, skin infections, and acute bacterial exacerbations of chronic bronchitis.

It has also been studied in sinusitis but is not approved for this use.

Final FDA approval for Spectracef(R) was granted August 29, 2001.

In Japan, it is marketed under the trade name “Meiact”.

Indications

  1. bronchitis
  2. community-acquired pneumonia
  3. Haemophilus influenzae (beta-lactamase negative)
  4. Haemophilus influenzae (beta-lactamase positive)
  5. Haemophilus parainfluenzae
  6. Moraxella catarrhalis
  7. pharyngitis
  8. pneumonia
  9. skin and skin structure infections
  10. Staphylococcus aureus (MSSA)
  11. Streptococcus agalactiae (group B streptococci)
  12. Streptococcus pneumoniae
  13. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  14. Streptococcus sp. (Group C)
  15. Streptococcus sp. (Group G)
  16. tonsillitis
  17. Viridans streptococci

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactic shock
  4. angioedema
  5. anorexia
  6. appetite stimulation
  7. arthralgia
  8. asthenia
  9. azotemia
  10. candidiasis
  11. cholestasis
  12. constipation
  13. diaphoresis
  14. diarrhea
  15. dizziness
  16. dysgeusia
  17. dyspepsia
  18. edema
  19. elevated hepatic enzymes
  20. eosinophilia
  21. eructation
  22. erythema multiforme
  23. fever
  24. flatulence
  25. headache
  26. hepatitis
  27. hyperbilirubinemia
  28. hyperglycemia
  29. insomnia
  30. interstitial nephritis
  31. jaundice
  32. leukopenia
  33. leukorrhea
  34. maculopapular rash
  35. myalgia
  36. nausea
  37. neutropenia
  38. oral ulceration
  39. pancytopenia
  40. peripheral edema
  41. pneumonitis
  42. polydipsia
  43. pruritus
  44. pseudomembranous colitis
  45. renal failure (unspecified)
  46. seizures
  47. serum sickness
  48. Stevens-Johnson syndrome
  49. stomatitis
  50. superinfection
  51. thrombocytopenia
  52. thrombocytosis
  53. toxic epidermal necrolysis
  54. urticaria
  55. vaginitis
  56. vomiting
  57. wheezing
  58. xerostomia

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • antimicrobial resistance
  • breast-feeding
  • carnitine deficiency
  • cephalosporin hypersensitivity
  • children
  • coagulopathy
  • colitis
  • diarrhea
  • geriatric
  • GI disease
  • hepatic disease
  • infants
  • inflammatory bowel disease
  • milk protein hypersensitivity
  • neonates
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • ulcerative colitis
  • viral infection
  • vitamin K deficiency

Interactions

  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Antacids
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Cimetidine
  • Colchicine; Probenecid
  • Dienogest; Estradiol valerate
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Famotidine
  • Famotidine; Ibuprofen
  • H2-blockers
  • Lanthanum Carbonate
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Loop diuretics
  • Magnesium Hydroxide
  • Magnesium Salts
  • Mestranol; Norethindrone
  • Nizatidine
  • Norethindrone
  • Norgestrel
  • Omeprazole; Sodium Bicarbonate
  • Oral Contraceptives
  • Probenecid
  • Ranitidine
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium Bicarbonate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Warfarin

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