Cefditoren Brand Name– Spectracef
What is Cefditoren
Cefditoren pivoxil (also known as ME-1206) is an oral prodrug for cefditoren. Cefditoren is a semi-synthetic, broad-spectrum, third generation cephalosporin that is a very potent oral beta-lactam antibiotic.
It is active against both beta-lactamase negative and positive Haemophilus influenzae, but is not active against Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Acinetobacter, and other non-fermentors. Cefditoren activity against Staphylococci is comparable to that of oxacillin.
It is also very active against Escherichia coli, Klebsiella spp, Proteus mirabilis, and Salmonella spp.
Cefditoren was studied in over 6000 adult and adolescent patients in clinical trials and is approved for the treatment of pharyngitis, tonsillitis, skin infections, and acute bacterial exacerbations of chronic bronchitis.
It has also been studied in sinusitis but is not approved for this use.
Final FDA approval for Spectracef(R) was granted August 29, 2001.
In Japan, it is marketed under the trade name “Meiact”.
Indications
- bronchitis
- community-acquired pneumonia
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus parainfluenzae
- Moraxella catarrhalis
- pharyngitis
- pneumonia
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Streptococcus agalactiae (group B streptococci)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Streptococcus sp. (Group C)
- Streptococcus sp. (Group G)
- tonsillitis
- Viridans streptococci
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactic shock
- angioedema
- anorexia
- appetite stimulation
- arthralgia
- asthenia
- azotemia
- candidiasis
- cholestasis
- constipation
- diaphoresis
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- edema
- elevated hepatic enzymes
- eosinophilia
- eructation
- erythema multiforme
- fever
- flatulence
- headache
- hepatitis
- hyperbilirubinemia
- hyperglycemia
- insomnia
- interstitial nephritis
- jaundice
- leukopenia
- leukorrhea
- maculopapular rash
- myalgia
- nausea
- neutropenia
- oral ulceration
- pancytopenia
- peripheral edema
- pneumonitis
- polydipsia
- pruritus
- pseudomembranous colitis
- renal failure (unspecified)
- seizures
- serum sickness
- Stevens-Johnson syndrome
- stomatitis
- superinfection
- thrombocytopenia
- thrombocytosis
- toxic epidermal necrolysis
- urticaria
- vaginitis
- vomiting
- wheezing
- xerostomia
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- antimicrobial resistance
- breast-feeding
- carnitine deficiency
- cephalosporin hypersensitivity
- children
- coagulopathy
- colitis
- diarrhea
- geriatric
- GI disease
- hepatic disease
- infants
- inflammatory bowel disease
- milk protein hypersensitivity
- neonates
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- ulcerative colitis
- viral infection
- vitamin K deficiency
Interactions
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Antacids
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Calcium Carbonate; Magnesium Hydroxide
- Cimetidine
- Colchicine; Probenecid
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Famotidine
- Famotidine; Ibuprofen
- H2-blockers
- Lanthanum Carbonate
- Leuprolide; Norethindrone
- Levonorgestrel
- Loop diuretics
- Magnesium Hydroxide
- Magnesium Salts
- Mestranol; Norethindrone
- Nizatidine
- Norethindrone
- Norgestrel
- Omeprazole; Sodium Bicarbonate
- Oral Contraceptives
- Probenecid
- Ranitidine
- Segesterone Acetate; Ethinyl Estradiol
- Sodium Bicarbonate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Warfarin
