Cefadroxil

Cefadroxil Brand Name– Duricef

What is Cefadroxil

Cefadroxil is an oral first-generation cephalosporin antibiotic.

Its spectrum includes gram-positive organisms, but it has limited gram-negative coverage.

Cefadroxil is indicated for the treatment of urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis.

This drug was approved by the FDA in 1978.

Indications

1. cystitis
2. Escherichia coli
3. impetigo
4. Klebsiella sp.
5. Moraxella catarrhalis
6. pharyngitis
7. Proteus mirabilis
8. rheumatic fever prophylaxis
9. skin and skin structure infections
10. Staphylococcus sp.
11. Streptococcus pneumoniae
12. Streptococcus pyogenes (group A beta-hemolytic streptococci)
13. tonsillitis
14. urinary tract infection (UTI)

Side Effects

1. abdominal pain
2. agranulocytosis
3. anaphylactoid reactions
4. angioedema
5. aplastic anemia
6. arthralgia
7. azotemia
8. bleeding
9. candidiasis
10. cholestasis
11. diarrhea
12. dyspepsia
13. elevated hepatic enzymes
14. eosinophilia
15. erythema multiforme
16. fever
17. hemolytic anemia
18. hepatic failure
19. hyperbilirubinemia
20. interstitial nephritis
21. nausea
22. neutropenia
23. pancytopenia
24. pruritus
25. pseudomembranous colitis
26. rash
27. seizures
28. serum sickness
29. Stevens-Johnson syndrome
30. superinfection
31. thrombocytopenia
32. toxic epidermal necrolysis
33. urticaria
34. vaginitis
35. vomiting

Monitoring Parameters

• serum creatinine/BUN

Contraindications

• breast-feeding
• cephalosporin hypersensitivity
• coagulopathy
• colitis
• diarrhea
• geriatric
• GI disease
• inflammatory bowel disease
• intramuscular injections
• neonates
• penicillin hypersensitivity
• pregnancy
• pseudomembranous colitis
• renal disease
• renal impairment
• ulcerative colitis
• viral infection
• vitamin K deficiency

Interactions

• Clofarabine
• Dienogest; Estradiol valerate
• Drospirenone
• Drospirenone; Estradiol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Elagolix; Estradiol; Norethindrone acetate
• Estradiol; Levonorgestrel
• Estradiol; Norethindrone
• Estradiol; Norgestimate
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Leuprolide; Norethindrone
• Levonorgestrel
• Loop diuretics
• Mestranol; Norethindrone
• Norethindrone
• Norgestrel
• Oral Contraceptives
• Segesterone Acetate; Ethinyl Estradiol
• Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
• Warfarin