Carbachol

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Carbachol Brand Names

Carbastat | Isopto Carbachol | Miostat

What is Carbachol

Carbachol is a direct-acting ophthalmic miotic agent.

Although carbachol is used exclusively as an ophthalmic preparation and extensive systemic absorption is not expected, systemic cholinergic side effects have been reported.

Therefore, careful monitoring is advisable in some patient populations. This drug was approved by the FDA in 1972.

Marketed products include carbachol ophthalmic solution (Isopto Carbachol) for lowering intraocular pressure in the treatment of glaucoma, and carbachol solution for intraocular injection (Miostat) for use as a miotic agent during surgery, and to decrease intraocular pressure following cataract surgery.

Indications

  1. glaucoma
  2. increased intraocular pressure
  3. miosis induction

For intraocular miosis induction during surgery and to reduce increased intraocular pressure during the first 24 hours after cataract surgery

Side Effects

  1. abdominal pain
  2. blurred vision
  3. bronchospasm
  4. ciliary body spasm
  5. conjunctival hyperemia
  6. corneal edema
  7. corneal opacification
  8. diarrhea
  9. flushing
  10. headache
  11. hyperhidrosis
  12. hypersalivation
  13. hypotension
  14. iritis
  15. keratopathy
  16. miosis
  17. night blindness
  18. ocular inflammation
  19. ocular irritation
  20. ocular pain
  21. retinal detachment
  22. sinus tachycardia
  23. syncope
  24. urinary retention
  25. urinary urgency
  26. visual impairment
  27. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acute heart failure
  • asthma
  • breast-feeding
  • cardiac disease
  • children
  • contact lenses
  • corneal abrasion
  • driving or operating machinery
  • hypertension
  • hyperthyroidism
  • hypotension
  • infants
  • iritis
  • latex hypersensitivity
  • myocardial infarction
  • neonates
  • Parkinson’s disease
  • peptic ulcer disease
  • pregnancy
  • retinal detachment
  • urinary tract obstruction

Interactions

There are no drug interactions associated with Carbachol products.

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