Captopril Brand Name– Capoten
What is Captopril
Captopril is an angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension, congestive heart failure, and various renal syndromes such as diabetic nephropathy and scleroderma.
Captopril is the first ACE inhibitor to have been marketed in the United States.
Captopril has been shown to significantly reduce mortality in patients with heart failure. As the shortest-acting of all ACE inhibitors, it is usually dosed two or three times a day.
Captopril contains a sulfhydryl group, which may contribute to its pharmacologic action and account for some adverse reactions that occur at higher doses.
Captopril was approved by the FDA in 1981.
Its patent expired on February 13, 1996.
Indications
- acute myocardial infarction
- diabetic nephropathy
- heart failure
- hypertension
- hypertensive emergency
- hypertensive urgency
- nephrotic syndrome
- postmyocardial infarction
- proteinuria
- scleroderma renal crisis
Side Effects
- abdominal pain
- agranulocytosis
- alopecia
- anaphylactoid reactions
- anemia
- angina
- angioedema
- anorexia
- aplastic anemia
- arrhythmia exacerbation
- arthralgia
- asthenia
- ataxia
- blurred vision
- bronchospasm
- cardiac arrest
- chest pain (unspecified)
- cholestasis
- confusion
- constipation
- cough
- depression
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- eosinophilia
- eosinophilic pneumonia
- erythema multiforme
- exfoliative dermatitis
- fatigue
- fever
- glossitis
- gynecomastia
- headache
- heart failure
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperkalemia
- hyponatremia
- hypotension
- increased urinary frequency
- insomnia
- jaundice
- leukocytosis
- maculopapular rash
- malaise
- myalgia
- myasthenia
- myocardial infarction
- nausea
- nephrotic syndrome
- neutropenia
- oliguria
- orthostatic hypotension
- pallor
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- peptic ulcer
- photosensitivity
- polyuria
- proteinuria
- pruritus
- renal failure (unspecified)
- rhinitis
- sinus tachycardia
- Stevens-Johnson syndrome
- syncope
- teratogenesis
- thrombocytopenia
- vasculitis
- vomiting
- weight loss
- xerostomia
Monitoring Parameters
- blood pressure
- serum creatinine/BUN
- serum potassium
- serum sodium
Contraindications
- ACE-inhibitor induced angioedema
- angioedema
- Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
- aortic stenosis
- autoimmune disease
- Black patients
- bone marrow suppression
- breast-feeding
- cardiomyopathy
- cerebrovascular disease
- collagen-vascular disease
- coronary artery disease
- diabetes mellitus
- dialysis
- geriatric
- heart failure
- hereditary angioedema
- history of angioedema
- hymenoptera venom (insect sting) allergy desensitization
- hyperkalemia
- hyponatremia
- hypotension
- hypovolemia
- immunosuppression
- infants
- jaundice
- low-density lipoprotein apheresis
- neonates
- pregnancy
- renal artery stenosis
- renal disease
- renal failure
- renal impairment
- scleroderma
- systemic lupus erythematosus (SLE)
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin; Metformin
- Alpha-glucosidase Inhibitors
- Alprostadil
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amifostine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amphetamine; Dextroamphetamine Salts
- Amyl Nitrite
- Angiotensin II
- Angiotensin II receptor antagonists
- Antacids
- Apomorphine
- Apraclonidine
- Aprotinin
- Aripiprazole
- Asenapine
- Azathioprine
- Azilsartan
- Azilsartan; Chlorthalidone
- Baclofen
- Benzphetamine
- Bosentan
- Brexpiprazole
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Cabergoline
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Phosphate, Supersaturated
- Canagliflozin; Metformin
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carvedilol
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloroprocaine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Colchicine; Probenecid
- Conivaptan
- Cyclophosphamide
- Cyclosporine
- Dapagliflozin; Metformin
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Diethylpropion
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enflurane
- Entecavir
- Ephedrine
- Eplerenone
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ertugliflozin; Metformin
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Etomidate
- Everolimus
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluorescein
- Fluoxetine; Olanzapine
- Fospropofol
- General anesthetics
- Glipizide; Metformin
- Glyburide; Metformin
- Gold
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Heparin
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Icatibant
- Iloperidone
- Iloprost
- Incretin Mimetics
- Indapamide
- Insulins
- Intravenous Lipid Emulsions
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Irbesartan
- Iron Dextran
- Isocarboxazid
- Isoflurane
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Isosulfan Blue
- Kanamycin
- Ketamine
- Lanthanum Carbonate
- Levodopa
- Linagliptin; Metformin
- Lisdexamfetamine
- Lithium
- Loop diuretics
- Loratadine; Pseudoephedrine
- Losartan
- Lovastatin; Niacin
- Lurasidone
- Magnesium Hydroxide
- Magnesium Salts
- Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
- Meglitinides
- Mesoridazine
- Mestranol; Norethindrone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methamphetamine
- Methohexital
- Methylphenidate
- Milrinone
- Naproxen; Pseudoephedrine
- Nateglinide
- Nebivolol; Valsartan
- Nefazodone
- Nesiritide, BNP
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nitrates
- Nitroglycerin
- Nitroprusside
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Olanzapine
- Olmesartan
- Oxymetazoline
- Paliperidone
- Pentoxifylline
- Phenelzine
- Phenylephrine
- Phenylephrine; Promethazine
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Potassium
- Pramlintide
- Prazosin
- Pregabalin
- Probenecid
- Procainamide
- Procaine
- Propofol
- Pseudoephedrine
- Quinidine
- Rasagiline
- Repaglinide
- Risperidone
- Sacubitril; Valsartan
- Salicylates
- Selegiline
- Sevoflurane
- SGLT2 Inhibitors
- Silodosin
- Sirolimus
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Spironolactone
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfonylureas
- Tacrolimus
- Telavancin
- Telbivudine
- Telmisartan
- Temsirolimus
- Tetrabenazine
- Tetracaine
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thiothixene
- Tizanidine
- Tolvaptan
- Tranylcypromine
- Trazodone
- Triamterene
- Trimethoprim
- Valsartan
- Yohimbine
- Ziprasidone
