Capmatinib Brand Name– TABRECTA
What is Capmatinib
Capmatinib is a kinase inhibitor targeting mesenchymal-epithelial transition (MET), including the mutant variant produced by exon 14 skipping.
It is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in patients whose tumors have a mutation that leads to MET exon 14 skipping as detected by an FDA-approved test.
Capmatinib has caused pneumonitis and hepatotoxicity in clinical trials; monitor patients for these adverse reactions as an interruption of therapy, dose reduction, or discontinuation of therapy may be necessary.
Capmatinib may also cause photosensitivity; it is advised that patients limit exposure to ultraviolet light and wear sunscreen or protective clothing during treatment.
Indications
- non-small cell lung cancer (NSCLC)
For the treatment of non-small cell lung cancer (NSCLC)
NOTE: Capmatinib is designated by the FDA as an orphan drug for this indication.
for the treatment of metastatic non-small cell lung cancer (NSCLC) in patients whose tumors have a mutation that leads to mesenchymal-epithelial transition (MET) exon 14 skipping
Side Effects
- anemia
- anorexia
- anorexia
- asthenia
- back pain
- back pain
- chest pain (unspecified)
- chest pain (unspecified)
- constipation
- constipation
- cough
- cough
- diarrhea
- diarrhea
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- fatigue
- fatigue
- fever
- fever
- hepatotoxicity
- hyperamylasemia
- hyperamylasemia
- hyperbilirubinemia
- hyperkalemia
- hypoalbuminemia
- hypoalbuminemia
- hypoglycemia
- hyponatremia
- hypophosphatemia
- infection
- infection
- interstitial lung disease
- interstitial lung disease
- leukopenia
- lymphopenia
- nausea
- nausea
- pancreatitis
- peripheral edema
- peripheral edema
- pleural effusion
- pneumonitis
- pneumonitis
- pruritus
- renal failure (unspecified)
- urticaria
- vomiting
- vomiting
- weight loss
- weight loss
Monitoring Parameters
- LFTs
- pregnancy testing
Contraindications
- breast-feeding
- chronic lung disease (CLD)
- contraception requirements
- hepatic disease
- hepatotoxicity
- male-mediated teratogenicity
- pneumonitis
- pregnancy
- pregnancy testing
- reproductive risk
- skin photosensitivity disorder
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Afatinib
- Alogliptin; Metformin
- Alpelisib
- Amlodipine; Atorvastatin
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Apalutamide
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendamustine
- Betrixaban
- Bexarotene
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bosentan
- Bupivacaine; Lidocaine
- Butabarbital
- Caffeine
- Caffeine; Ergotamine
- Canagliflozin; Metformin
- Carbamazepine
- Cenobamate
- Ceritinib
- Chloramphenicol
- Clarithromycin
- Clozapine
- Cobicistat
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Cyclosporine
- Dabigatran
- Dabrafenib
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexamethasone
- Digoxin
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxorubicin
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Enzalutamide
- Ertugliflozin; Metformin
- Eslicarbazepine
- Etravirine
- Everolimus
- Fosamprenavir
- Fosphenytoin
- Glecaprevir; Pibrentasvir
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- grapefruit juice
- Hydrochlorothiazide, HCTZ; Propranolol
- Idelalisib
- Indinavir
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lapatinib
- Lefamulin
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin; Metformin
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Maraviroc
- Mefloquine
- Melatonin
- Mephobarbital
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methohexital
- Mexiletine
- Mifepristone
- Mitotane
- Modafinil
- Morphine
- Morphine; Naltrexone
- Nafcillin
- Naldemedine
- Nefazodone
- Nelfinavir
- Nevirapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ozanimod
- Pazopanib
- Pentobarbital
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Propranolol
- Ranolazine
- Rasagiline
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rimegepant
- Ritonavir
- Rosuvastatin
- Saquinavir
- Saxagliptin
- Secobarbital
- Silodosin
- Sirolimus
- St. John’s Wort, Hypericum perforatum
- Sulfasalazine
- Talazoparib
- Telithromycin
- Temsirolimus
- Tenofovir Alafenamide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Theophylline, Aminophylline
- Thiopental
- Ticagrelor
- Tipranavir
- Tizanidine
- Tolvaptan
- Topotecan
- Tucatinib
- Ubrogepant
- Venetoclax
- Vincristine
- Vincristine Liposomal
- Voriconazole
- Warfarin
