Can combinations of two or more DMARDs be used in the treatment of RA

Can combinations of two or more DMARDs be used in the treatment of RA?

Yes. The role of combination DMARD therapy in the treatment of RA continues to evolve. With the addition of new medications, more therapeutic combinations are possible than ever before. Most clinical trials of combination therapy with DMARDs have included MTX. Several studies have shown that combination therapy with MTX, whether step-up or as initial therapy, is more beneficial than MTX alone. The following are some combinations that have been studied:

  • • MTX and HCQ.
  • • MTX, HCQ, and SSZ (triple therapy).
  • • MTX and leflunomide (typically MTX plus 10 mg of leflunomide).
  • • MTX and azathioprine.
  • • MTX and biologic agents.
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