How is minocycline used for Rheumatoid Arthritis?
Minocycline is a tetracycline antibiotic that has been shown to reduce disease activity in RA. In clinical practice, it is used more in mild disease and has the benefit of not being immunosuppressant (as such it can be a good choice for those with comorbidities such as chronic obstructive pulmonary disorder). It is dosed at 100 mg twice daily, and side effects include hyperpigmentation (with long-term use, blue-black in arms and legs), dizziness, and photosensitivity. Cost is approximately $65/month.
