Systemic Antirheumatic Drugs

Systemic Antirheumatic Drugs

  • 1. Choice of disease-modifying antirheumatic drug (DMARD) therapy is based on disease severity, comorbidities, and fertility plans.
  • 2. Hydroxychloroquine (HCQ) or sulfasalazine (SSZ) monotherapy is best used for mild rheumatoid arthritis (RA).
  • 3. Methotrexate (MTX) is the most effective DMARD for RA and often the anchor drug for all combination therapies.
  • 4. Combination DMARD therapy is more effective than monotherapy in severe RA.
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