Calcium Carbonate Risedronate Brand Name– Actonel with Calcium
What is Calcium Carbonate Risedronate
Calcium Carbonate Risedronate is a co-packaged product of once weekly risedronate (35 mg/week) and once daily calcium carbonate (1250 mg/day, equivalent to 500 mg/day elemental calcium) for the remaining 6 days of the week.
The product is used to increase bone mass to treat or prevent osteoporosis in postmenopausal women.
Risedronate is a potent oral second-generation pyridinyl bisphosphonate; it differs structurally from other available bisphosphonates due to the pyridinyl side chain shielding the active amino group.
Treatment with risedronate is associated with significant increases in bone mineral density (BMD) and reduces the risk for radiographic vertebral and non-vertebral fractures (e.g., hip fractures).
Bisphosphonates such as risedronate are generally considered to be first-line therapy for the treatment of osteoporosis in postmenopausal women.
For osteoporosis prevention, the second and third-generation bisphosphonates appear to offer similar benefits across the class to increase bone mineral density; the balance of costs, benefits, and harms of treating osteopenic patients with bisphosphonates is most favorable when the estimated risk for fracture is high.
As with other bisphosphonate products, supplements of vitamin D are recommended if dietary intake is inadequate and some patients may need additional calcium to provide adequate intake for their condition(s).
The risedronate with calcium product was initially approved by the FDA in 2005.
Indications
- osteoporosis
- osteoporosis prophylaxis
Side Effects
- abdominal pain
- angioedema
- arthralgia
- asthenia
- atrial fibrillation
- back pain
- bone fractures
- bone pain
- bullous rash
- cataracts
- chest pain (unspecified)
- conjunctivitis
- constipation
- depression
- diarrhea
- dizziness
- dysphagia
- eructation
- esophageal ulceration
- esophagitis
- flatulence
- gastric hypersecretion
- gastritis
- glossitis
- headache
- hypercalcemia
- hypertension
- hypocalcemia
- hypophosphatemia
- infection
- insomnia
- iritis
- metabolic alkalosis
- milk-alkali syndrome
- myalgia
- nausea
- nephrolithiasis
- ocular inflammation
- ocular pain
- oral ulceration
- osteonecrosis
- peptic ulcer
- peripheral edema
- pharyngitis
- pyrosis (heartburn)
- rash
- rhinitis
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- uveitis
- visual impairment
- vomiting
- weakness
Monitoring Parameters
- serum 25(OH)hydroxyvitamin D concentrations
- serum alkaline phosphatase
- serum calcium
- serum creatinine/BUN
- serum phosphate
Contraindications
- achlorhydria
- anemia
- breast-feeding
- chemotherapy
- children
- coagulopathy
- constipation
- corticosteroid therapy
- dehydration
- dental disease
- dental work
- dysphagia
- esophagitis
- gastritis
- gastroesophageal reflux disease (GERD)
- geriatric
- GI bleeding
- GI disease
- GI obstruction
- hiatal hernia
- hypercalcemia
- hypercalciuria
- hyperparathyroidism
- hypocalcemia
- ileus
- infection
- laboratory test interference
- nephrolithiasis
- peptic ulcer disease
- phosphonate hypersensitivity
- pregnancy
- renal disease
- renal failure
- renal impairment
- sarcoidosis
- vitamin D deficiency
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Acalabrutinib
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminosalicylate sodium, Aminosalicylic acid
- Amlodipine; Atorvastatin
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Anticholinergics
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
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- Atenolol; Chlorthalidone
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine; Fluticasone
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- Baloxavir Marboxil
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- Benazepril; Hydrochlorothiazide, HCTZ
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- Benzphetamine
- Benztropine
- Betamethasone
- Betamethasone; Calcipotriene
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bisacodyl
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bisphosphonates
- Bosutinib
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Calcipotriene
- Calcitonin
- Calcium
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Simethicone
- Calcium Chloride
- Calcium Gluconate
- Calcium Phosphate, Supersaturated
- Calcium; Vitamin D
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Pseudoephedrine
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- Carbinoxamine; Pseudoephedrine
- Cardiac glycosides
- Cefdinir
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- Cefuroxime
- Celecoxib
- Cetirizine; Pseudoephedrine
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- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Pseudoephedrine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Choline Salicylate; Magnesium Salicylate
- Chromium
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- Diazepam
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- Enalapril; Hydrochlorothiazide, HCTZ
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- Esomeprazole
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- Estradiol; Norgestimate
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- Estramustine
- Estrogens
- Estropipate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethotoin
- Etodolac
- Ezetimibe
- Ezetimibe; Simvastatin
- Famotidine
- Famotidine; Ibuprofen
- Fenoprofen
- Fexofenadine
- Fexofenadine; Pseudoephedrine
- Flavoxate
- Fludrocortisone
- Flunisolide
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- food
- Fosamprenavir
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Gabapentin
- Gallium
- Gastrointestinal Enzymes
- Gefitinib
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Pseudoephedrine
- H2-blockers
- Hetastarch; Dextrose; Electrolytes
- Homatropine; Hydrocodone
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Ibuprofen
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone
- Hydroxychloroquine
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indacaterol; Glycopyrrolate
- Indomethacin
- Iron
- Iron Salts
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lactulose
- Lansoprazole
- Lansoprazole; Naproxen
- Lanthanum Carbonate
- Ledipasvir; Sofosbuvir
- Levofloxacin
- Lisdexamfetamine
- Loratadine; Pseudoephedrine
- Magnesium
- Magnesium Citrate
- Magnesium Hydroxide
- Magnesium Salicylate
- Magnesium Salts
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Meloxicam
- Mepenzolate
- Mesalamine, 5-ASA
- Mestranol; Norethindrone
- Methamphetamine
- Methenamine
- Methenamine; Sodium Acid Phosphate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methscopolamine
- Methyclothiazide
- Methylphenidate
- Methylprednisolone
- Metolazone
- Moxifloxacin
- Mycophenolate
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Neratinib
- Neuromuscular blockers
- Nilotinib
- Nitrofurantoin
- Nizatidine
- Nonsteroidal antiinflammatory drugs
- Norfloxacin
- Ofloxacin
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oxaprozin
- Oxybutynin
- Pancrelipase
- Pantoprazole
- Pazopanib
- Penicillamine
- Phenytoin
- Phosphorated Carbohydrate Solution
- Phosphorus
- Piroxicam
- Polycarbophil
- Polyethylene Glycol; Electrolytes; Bisacodyl
- Polysaccharide-Iron Complex
- Ponatinib
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Potassium Phosphate
- Potassium Phosphate; Sodium Phosphate
- Prednisolone
- Prednisone
- Propantheline
- Propranolol
- Proton pump inhibitors
- Pseudoephedrine
- Quinidine
- Quinine
- Rabeprazole
- Raltegravir
- Ranitidine
- Rifampin
- Rilpivirine
- Riociguat
- Rofecoxib
- Rosuvastatin
- Salicylates
- Salsalate
- Scopolamine
- Segesterone Acetate; Ethinyl Estradiol
- Selpercatinib
- Sodium Bicarbonate
- Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
- Sodium Fluoride
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium Polystyrene Sulfonate
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sotalol
- Sucralfate
- Sulindac
- Tetracyclines
- Thiazide diuretics
- Thiothixene
- Thyroid hormones
- Ticlopidine
- Tipranavir
- Tolmetin
- Triamcinolone
- Trihexyphenidyl
- Valdecoxib
- Valproic Acid, Divalproex Sodium
- Vitamin A
- Vitamin D analogs