Calcium Carbonate

Calcium Carbonate Brand Names

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What is Calcium Carbonate

Calcium carbonate is an inorganic salt that was once a popular antacid but is now more commonly used as a calcium supplement.

While some studies have claimed that the oral bioavailability (measured via urinary excretion) of calcium is greater from calcium citrate than calcium carbonate, other studies using biologic tracers have noted similar oral bioavailability of the two calcium supplements after administration with food.

Given that calcium citrate is usually much more expensive than calcium carbonate, the less expensive carbonate form may be favored in selected patients where drug cost is a factor.

Calcium carbonate is also commonly used to bind dietary phosphate in the gut in patients with hyperphosphatemia and chronic renal disease.

The drug has also been effective in addressing mild symptoms associated with premenstrual syndrome.

Calcium carbonate was in use prior to 1938 and was approved by the FDA at its inception.

Indications

  1. duodenal ulcer
  2. dyspepsia
  3. hyperphosphatemia
  4. hypocalcemia
  5. nutritional supplementation
  6. osteoporosis prophylaxis
  7. premenstrual syndrome (PMS)
  8. pyrosis (heartburn)
  9. stress gastritis
  10. stress gastritis prophylaxis

Side Effects

  1. constipation
  2. eructation
  3. flatulence
  4. gastric hypersecretion
  5. hypercalcemia
  6. hypophosphatemia
  7. metabolic alkalosis
  8. milk-alkali syndrome
  9. myasthenia
  10. nausea
  11. nephrolithiasis
  12. polydipsia
  13. polyuria
  14. vomiting

Monitoring Parameters

  • serum calcium
  • serum phosphate

Contraindications

  • breast-feeding
  • constipation
  • dehydration
  • GI bleeding
  • GI obstruction
  • hypercalcemia
  • hypercalciuria
  • hyperparathyroidism
  • ileus
  • necrotizing enterocolitis
  • neoplastic disease
  • nephrolithiasis
  • peptic ulcer disease
  • pregnancy
  • renal disease
  • sarcoidosis

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Acalabrutinib
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Pseudoephedrine
  • Acrivastine; Pseudoephedrine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amlodipine; Atorvastatin
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamines
  • Anticholinergics
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine; Fluticasone
  • Azilsartan; Chlorthalidone
  • Baloxavir Marboxil
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Bempedoic Acid; Ezetimibe
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Benztropine
  • Betamethasone
  • Betamethasone; Calcipotriene
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Bisacodyl
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bisphosphonates
  • Bosutinib
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Calcipotriene
  • Calcitonin
  • Calcium Phosphate, Supersaturated
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Pseudoephedrine
  • Cardiac glycosides
  • Cefdinir
  • Cefpodoxime
  • Cefuroxime
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlordiazepoxide; Clidinium
  • Chloroquine
  • Chlorothiazide
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Choline Salicylate; Magnesium Salicylate
  • Ciprofloxacin
  • Citric Acid; Potassium Citrate
  • Citric Acid; Potassium Citrate; Sodium Citrate
  • Citric Acid; Sodium Citrate
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Corticotropin, ACTH
  • Cortisone
  • Cysteamine
  • Dabrafenib
  • Dasatinib
  • Delafloxacin
  • Delavirdine
  • Desloratadine; Pseudoephedrine
  • Dexamethasone
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Dicyclomine
  • Dienogest; Estradiol valerate
  • Diethylstilbestrol, DES
  • Diflunisal
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dolutegravir
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Edetate Calcium Disodium, Calcium EDTA
  • Edetate Disodium, Disodium EDTA
  • Elagolix; Estradiol; Norethindrone acetate
  • Eltrombopag
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Erdafitinib
  • Erlotinib
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estramustine
  • Estrogens
  • Estropipate
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
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  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethotoin
  • Ezetimibe
  • Ezetimibe; Simvastatin
  • Fexofenadine
  • Fexofenadine; Pseudoephedrine
  • Flavoxate
  • Fludrocortisone
  • Flunisolide
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • food
  • Fosamprenavir
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gabapentin
  • Gallium
  • Gastrointestinal Enzymes
  • Gefitinib
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydrocortisone
  • Hydroxychloroquine
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
  • Ibuprofen; Pseudoephedrine
  • Indacaterol; Glycopyrrolate
  • Indomethacin
  • Iron
  • Iron Salts
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ketoconazole
  • Lactulose
  • Ledipasvir; Sofosbuvir
  • Levofloxacin
  • Lisdexamfetamine
  • Loratadine; Pseudoephedrine
  • Magnesium Salicylate
  • Mefenamic Acid
  • Mefloquine
  • Mepenzolate
  • Mesalamine, 5-ASA
  • Mestranol; Norethindrone
  • Methamphetamine
  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methscopolamine
  • Methyclothiazide
  • Methylphenidate
  • Methylprednisolone
  • Metolazone
  • Moxifloxacin
  • Mycophenolate
  • Naproxen; Pseudoephedrine
  • Neratinib
  • Neuromuscular blockers
  • Nilotinib
  • Nitrofurantoin
  • Norfloxacin
  • Ofloxacin
  • Omeprazole; Sodium Bicarbonate
  • Oxybutynin
  • Pancrelipase
  • Pazopanib
  • Penicillamine
  • Phenytoin
  • Phosphorated Carbohydrate Solution
  • Phosphorus
  • Polyethylene Glycol; Electrolytes; Bisacodyl
  • Polysaccharide-Iron Complex
  • Ponatinib
  • Potassium Bicarbonate
  • Potassium Chloride
  • Potassium Citrate
  • Potassium Phosphate
  • Potassium Phosphate; Sodium Phosphate
  • Prednisolone
  • Prednisone
  • Propantheline
  • Propranolol
  • Pseudoephedrine
  • Quinidine
  • Quinine
  • Raltegravir
  • Rifampin
  • Rilpivirine
  • Riociguat
  • Rosuvastatin
  • Salicylates
  • Salsalate
  • Scopolamine
  • Segesterone Acetate; Ethinyl Estradiol
  • Selpercatinib
  • Sodium Bicarbonate
  • Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
  • Sodium Fluoride
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Sodium Polystyrene Sulfonate
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Sotalol
  • Sucralfate
  • Tetracyclines
  • Thiazide diuretics
  • Thiothixene
  • Thyroid hormones
  • Ticlopidine
  • Tipranavir
  • Triamcinolone
  • Trientine
  • Trihexyphenidyl
  • Valproic Acid, Divalproex Sodium
  • Vitamin A
  • Vitamin D analogs
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