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Caffeine Ergotamine Brand Names
Cafergot | Migergot
What is Caffeine Ergotamine
Caffeine and ergotamine are used in combination as an abortive treatment for migraine and cluster headaches.
This medication is still considered a primary treatment option by many clinicians because of its efficacy in controlling up to 70% of migraine attacks in adults and its relative cost advantage compared to other anti-migraine medications.
Prolonged use or excessive dosage of this drug combination can lead to ergotism, dependence, and/or rebound headaches. Caffeine; ergotamine should be prescribed in strict accordance with the manufacturer’s guidelines.
Maximum daily and weekly dosage limits should not be exceeded. A suppository formulation of the drug is available for those who cannot tolerate oral administration due to nausea/vomiting during migraine attacks.
Ergotamine was first used medically to treat migraines in the 1920’s, and was approved by the FDA in 1960.
Indications
- headache
- migraine
For the abortive treatment of acute migraine or cluster headache
Side Effects
- abdominal pain
- angina
- bowel ischemia
- bradycardia
- cardiac valvulopathy
- chest pain (unspecified)
- colitis
- coronary vasospasm
- diarrhea
- drowsiness
- edema
- fetal death
- headache
- hypertension
- muscle cramps
- myalgia
- myocardial infarction
- nausea
- paresthesias
- peripheral vasoconstriction
- physiological dependence
- polyuria
- pruritus
- pulmonary fibrosis
- renal tubular necrosis
- retroperitoneal fibrosis
- sinus tachycardia
- spontaneous fetal abortion
- tissue necrosis
- tremor
- urticaria
- uterine contractions
- vertigo
- vomiting
- weakness
- withdrawal
Monitoring Parameters
- blood pressure
- heart rate
Contraindications
- angina
- arteriosclerosis
- basilar/hemiplegic migraine
- biliary tract disease
- breast-feeding
- cardiac disease
- children
- cholestasis
- coronary artery disease
- diabetes mellitus
- eclampsia
- ergot alkaloid hypersensitivity
- geriatric
- hepatic disease
- hypercholesterolemia
- hypertension
- infants
- labor
- myocardial infarction
- obesity
- obstetric delivery
- peripheral vascular disease
- peripheral vasoconstriction or ischemia
- postmenopausal females
- preeclampsia
- pregnancy
- pulmonary disease
- pulmonary fibrosis
- Raynaud’s phenomenon
- renal disease
- renal failure
- renal impairment
- retroperitoneal fibrosis
- sepsis
- stroke
- surgery
- thromboangiitis obliterans (Buerger’s disease)
- thrombophlebitis
- tobacco smoking
- valvular heart disease
Interactions
- Acebutolol
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Adenosine
- Albuterol
- Albuterol; Ipratropium
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Almotriptan
- Alprazolam
- Amantadine
- Amiodarone
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Anagrelide
- Aprepitant, Fosaprepitant
- Arformoterol
- Armodafinil
- Articaine; Epinephrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Dipyridamole
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Benzodiazepines
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Beta-agonists
- Beta-blockers
- Betaxolol
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bosentan
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide; Formoterol
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Bupropion
- Bupropion; Naltrexone
- Butabarbital
- Cabergoline
- Caffeine
- Cannabidiol
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carteolol
- Carvedilol
- Ceritinib
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloroprocaine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Cimetidine
- Ciprofloxacin
- Citalopram
- Clarithromycin
- Clofazimine
- Clozapine
- Cobicistat
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Conivaptan
- Crizotinib
- Danazol
- Darifenacin
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Delavirdine
- Desloratadine; Pseudoephedrine
- Desvenlafaxine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Diazoxide
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Dipyridamole
- Dirithromycin
- Disulfiram
- Dobutamine
- Dopamine
- Dorzolamide; Timolol
- Dronedarone
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Dyphylline
- Dyphylline; Guaifenesin
- Echinacea
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emapalumab
- Enzalutamide
- Ephedrine
- Epinephrine
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Esmolol
- Eszopiclone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Everolimus
- Fedratinib
- Fenoldopam
- Fesoterodine
- Fexofenadine; Pseudoephedrine
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Fostamatinib
- Frovatriptan
- Givosiran
- Glycerol Phenylbutyrate
- Glycopyrrolate; Formoterol
- grapefruit juice
- Green Tea
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Hydantoins
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Imatinib
- Indacaterol
- Indacaterol; Glycopyrrolate
- Isavuconazonium
- Isocarboxazid
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Istradefylline
- Itraconazole
- Ivacaftor
- Ketoconazole
- Ketoprofen
- Labetalol
- Lanreotide
- Lapatinib
- Larotrectinib
- Lefamulin
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levalbuterol
- Levobetaxolol
- Levobunolol
- Levomilnacipran
- Linezolid
- Lisdexamfetamine
- Lithium
- Loratadine; Pseudoephedrine
- Lorcaserin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mephobarbital
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mestranol; Norethindrone
- Metaproterenol
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
- Methylene Blue
- Methylphenidate
- Metoprolol
- Metronidazole
- Mexiletine
- Miconazole
- Midodrine
- Mifepristone
- Milnacipran
- Minoxidil
- Mirtazapine
- Mitotane
- Modafinil
- Monoamine oxidase inhibitors
- Nadolol
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Naratriptan
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nicardipine
- Nicotine
- Nilotinib
- Nitrates
- Nitroprusside
- Non-Ionic Contrast Media
- Norepinephrine
- Norfloxacin
- Obeticholic Acid
- Olodaterol
- Oritavancin
- Oxybutynin
- Palbociclib
- Paroxetine
- Pazopanib
- Peginterferon Alfa-2b
- Pemoline
- Penbutolol
- Pentobarbital
- Perindopril; Amlodipine
- Phendimetrazine
- Phenelzine
- Phenobarbital
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Pindolol
- Pirbuterol
- Posaconazole
- Prilocaine
- Prilocaine; Epinephrine
- Primidone
- Procaine
- Procarbazine
- Propranolol
- Protease inhibitors
- Pseudoephedrine
- Quinine
- Racepinephrine
- Ramelteon
- Ranolazine
- Rasagiline
- Regadenoson
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Ritodrine
- Rizatriptan
- Rucaparib
- Rufinamide
- Salmeterol
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Sertraline
- Sibutramine
- Simeprevir
- Sodium Oxybate
- Solifenacin
- Solriamfetol
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Sumatriptan
- Suvorexant
- Tasimelteon
- Tedizolid
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Terbinafine
- Terbutaline
- Teriflunomide
- Tezacaftor; Ivacaftor
- Theophylline, Aminophylline
- Thiabendazole
- Thiopental
- Timolol
- Tiotropium; Olodaterol
- tobacco
- Tolterodine
- Trandolapril; Verapamil
- Tranylcypromine
- Umeclidinium; Vilanterol
- Vasopressors
- Vemurafenib
- Venlafaxine
- Verapamil
- Vilazodone
- Voriconazole
- Vortioxetine
- Yohimbine
- Zafirlukast
- Zaleplon
- Zileuton
- Zolmitriptan
- Zolpidem
