Cabozantinib

Cabozantinib Brand Names

Cabometyx | COMETRIQ

What is Cabozantinib

Cabozantinib is an oral multi-tyrosine kinase inhibitor. Cabozantinib (capsules, Cometriq) is indicated for the treatment of progressive, metastatic medullary thyroid cancer.

Cabozantinib (tablets, Cabometyx) is indicated for the treatment of advanced renal cell carcinoma and for the treatment of hepatocellular carcinoma in patients who have been previously treated with sorafenib.

Gastrointestinal perforation, fistulas, and severe hemorrhage have been reported with cabozantinib therapy.

Indications

1. hepatocellular cancer
2. renal cell cancer
3. thyroid cancer

For the treatment of progressive, metastatic medullary thyroid cancer

Side Effects

1. abdominal pain
2. abdominal pain
3. acneiform rash
4. alopecia
5. anemia
6. anemia
7. anorexia
8. anorexia
9. anxiety
10. arthralgia
11. arthralgia
12. asthenia
13. asthenia
14. back pain
15. bleeding
16. bone pain
17. cardiac arrest
18. confusion
19. constipation
20. constipation
21. contact dermatitis
22. cough
23. cough
24. dehydration
25. dehydration
26. dental pain
27. depression
28. diarrhea
29. diarrhea
30. dizziness
31. dysgeusia
32. dyspepsia
33. dyspepsia
34. dysphagia
35. dysphagia
36. dysphonia
37. dysphonia
38. dyspnea
39. dyspnea
40. elevated hepatic enzymes
41. elevated hepatic enzymes
42. erythema
43. erythema
44. exfoliative dermatitis
45. fatigue
46. fatigue
47. gastrointestinal fistula
48. GI bleeding
49. GI perforation
50. glossitis
51. glossitis
52. hair discoloration
53. headache
54. headache
55. hemoptysis
56. hemorrhoids
57. hepatic failure
58. hepatitis
59. hyperamylasemia
60. hyperamylasemia
61. hyperbilirubinemia
62. hyperbilirubinemia
63. hyperglycemia
64. hyperglycemia
65. hyperkalemia
66. hyperkeratosis
67. hypertension
68. hypertension
69. hypertriglyceridemia
70. hypertriglyceridemia
71. hypoalbuminemia
72. hypoalbuminemia
73. hypocalcemia
74. hypocalcemia
75. hypokalemia
76. hypokalemia
77. hypomagnesemia
78. hypomagnesemia
79. hyponatremia
80. hyponatremia
81. hypophosphatemia
82. hypophosphatemia
83. hypotension
84. hypotension
85. hypothyroidism
86. hypothyroidism
87. impaired wound healing
88. infection
89. leukoencephalopathy
90. leukopenia
91. leukopenia
92. lymphopenia
93. lymphopenia
94. maculopapular rash
95. muscle cramps
96. muscle cramps
97. musculoskeletal pain
98. musculoskeletal pain
99. nausea
100. nausea
101. nephrotic syndrome
102. neutropenia
103. neutropenia
104. oral ulceration
105. oral ulceration
106. osteomyelitis
107. osteonecrosis
108. palmar-plantar erythrodysesthesia (hand and foot syndrome)
109. palmar-plantar erythrodysesthesia (hand and foot syndrome)
110. pancreatitis
111. paresthesias
112. peripheral neuropathy
113. proteinuria
114. proteinuria
115. pulmonary embolism
116. rash
117. rash
118. renal failure (unspecified)
119. seizures
120. skin ulcer
121. stomatitis
122. stomatitis
123. syncope
124. thrombocytopenia
125. thrombocytopenia
126. thromboembolism
127. thrombosis
128. tracheoesophageal fistula
129. vesicular rash
130. visual impairment
131. vomiting
132. vomiting
133. weight loss
134. weight loss
135. wound dehiscence
136. xerosis

Monitoring Parameters

• blood pressure
• LFTs
• pregnancy testing
• urinalysis

Contraindications

• bleeding
• breast-feeding
• contraception requirements
• dental disease
• dental work
• diarrhea
• encephalopathy
• fistula
• GI perforation
• hepatic disease
• hypertension
• impaired wound healing
• infertility
• myocardial infarction
• pregnancy
• pregnancy testing
• proteinuria
• reproductive risk
• skin disease
• surgery
• thromboembolism
• wound dehiscence

Interactions

• Abacavir
• Abacavir; Dolutegravir; Lamivudine
• Abacavir; Lamivudine, 3TC
• Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
• Adefovir
• Afatinib
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Apalutamide
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• Atazanavir; Cobicistat
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Betrixaban
• Budesonide
• Budesonide; Formoterol
• Carbamazepine
• Carvedilol
• Ceritinib
• Chloramphenicol
• Cidofovir
• Clarithromycin
• Cobicistat
• Cobimetinib
• Colchicine
• Colchicine; Probenecid
• Conivaptan
• Cyclosporine
• Dabigatran
• Dapagliflozin; Saxagliptin
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Delavirdine
• Dexamethasone
• Dextromethorphan; Quinidine
• Digoxin
• Docetaxel
• Dolutegravir
• Dolutegravir; Lamivudine
• Dolutegravir; Rilpivirine
• Doravirine; Lamivudine; Tenofovir disoproxil fumarate
• Doxorubicin
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• Drospirenone; Ethinyl Estradiol; Levomefolate
• Efavirenz; Emtricitabine; Tenofovir
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• Eletriptan
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Emtricitabine; Tenofovir disoproxil fumarate
• Enzalutamide
• Erythromycin
• Erythromycin; Sulfisoxazole
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
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• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Everolimus
• Fexofenadine
• Fexofenadine; Pseudoephedrine
• Fosamprenavir
• Fosphenytoin
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• Glecaprevir; Pibrentasvir
• Glyburide
• Glyburide; Metformin
• grapefruit juice
• Idelalisib
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• Lamivudine, 3TC
• Lamivudine, 3TC; Zidovudine, ZDV
• Lamivudine; Tenofovir Disoproxil Fumarate
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• Tenofovir, PMPA
• Testosterone
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