Cabergoline Brand Name– Dostinex
What is Cabergoline
Cabergoline is a synthetic ergoline-derived dopamine agonist that is indicated for the treatment of hyperprolactinemic disorders, either idiopathic or because of pituitary adenomas.
Until the availability of cabergoline in 1996, bromocriptine was the only agent approved by the FDA for the treatment of hyperprolactinemias.
Results from comparative studies of the two medications indicate that cabergoline is more effective than bromocriptine in suppressing prolactin secretion and it has a more favorable tolerability profile. In addition, the unique dosing strategy of cabergoline is a potential advantage of the drug.
Whereas bromocriptine requires multiple daily dosages for effectiveness, cabergoline has a long half-life and is administered once to twice weekly for hyperprolactinemia.
Although there is evidence for the efficacy of cabergoline in the treatment of restless legs syndrome, the drug is rarely used in clinical practice because of the risk of cardiac valvulopathy and the availability of safer alternatives.
Indications
- hyperprolactinemia
- pituitary adenoma
- restless legs syndrome (RLS)
For the treatment of hyperprolactinemia, either idiopathic or due to a pituitary adenoma
Side Effects
- abdominal pain
- acne vulgaris
- alopecia
- anorexia
- anxiety
- arthralgia
- asthenia
- cardiac valvulopathy
- confusion
- constipation
- cough
- dental pain
- diarrhea
- dizziness
- drowsiness
- dyskinesia
- dysmenorrhea
- dyspepsia
- edema
- epistaxis
- fatigue
- flatulence
- fluid retention
- hallucinations
- headache
- heart failure
- hot flashes
- hypotension
- impulse control symptoms
- insomnia
- libido increase
- malaise
- mastalgia
- musculoskeletal pain
- nasal congestion
- nausea
- orthostatic hypotension
- palpitations
- paresthesias
- peptic ulcer
- pericarditis
- peripheral edema
- pleural effusion
- pruritus
- psychosis
- pulmonary fibrosis
- retroperitoneal fibrosis
- rhinitis
- syncope
- throat irritation
- vertigo
- visual impairment
- vomiting
- weight gain
- weight loss
- xerostomia
Monitoring Parameters
- blood pressure
- chest x-ray
- echocardiogram
- LFTs
- serum creatinine
- serum prolactin
Contraindications
- breast-feeding
- children
- constrictive pericarditis
- eclampsia
- ergot alkaloid hypersensitivity
- geriatric
- hepatic disease
- hypertension
- hypotension
- impulse control symptoms
- infants
- orthostatic hypotension
- preeclampsia
- pregnancy
- pregnancy testing
- pulmonary fibrosis
- retroperitoneal fibrosis
- valvular heart disease
Interactions
- Acebutolol
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alpha-blockers
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amyl Nitrite
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Aripiprazole
- Asenapine
- Atenolol
- Atenolol; Chlorthalidone
- Azilsartan
- Azilsartan; Chlorthalidone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Beta-blockers
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brexpiprazole
- Brimonidine; Timolol
- Bumetanide
- Caffeine; Ergotamine
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Cariprazine
- Carteolol
- Carvedilol
- Chlorothiazide
- Chlorpromazine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Clomipramine
- Clonidine
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Diethylpropion
- Dihydroergotamine
- Diltiazem
- Dorzolamide; Timolol
- Doxazosin
- Droperidol
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Esmolol
- Ethacrynic Acid
- Felodipine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Furosemide
- Guanfacine
- Haloperidol
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Iloperidone
- Indapamide
- Irbesartan
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Isradipine
- Labetalol
- Levobetaxolol
- Levobunolol
- Lisinopril
- Loop diuretics
- Lorcaserin
- Losartan
- Loxapine
- Lumateperone
- Lurasidone
- Mecamylamine
- Meperidine; Promethazine
- Mesoridazine
- Methyclothiazide
- Methyldopa
- Methylergonovine
- Methysergide
- Metoclopramide
- Metolazone
- Metoprolol
- Minoxidil
- Moexipril
- Molindone
- Nadolol
- Nebivolol
- Nebivolol; Valsartan
- Nicardipine
- Nifedipine
- Nisoldipine
- Nitrates
- Nitroglycerin
- Nitroprusside
- Olanzapine
- Olmesartan
- Paliperidone
- Penbutolol
- Pergolide
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenothiazines
- Phenoxybenzamine
- Phentolamine
- Phenylephrine; Promethazine
- Pimozide
- Pindolol
- Potassium-sparing diuretics
- Prazosin
- Prochlorperazine
- Promethazine
- Propranolol
- Quetiapine
- Quinapril
- Ramelteon
- Ramipril
- Reserpine
- Risperidone
- Sacubitril; Valsartan
- Sotalol
- Spironolactone
- Telmisartan
- Terazosin
- Tetrabenazine
- Thiazide diuretics
- Thiethylperazine
- Thioridazine
- Thiothixene
- Timolol
- tobacco
- Torsemide
- Trandolapril
- Trandolapril; Verapamil
- Triamterene
- Trifluoperazine
- Valbenazine
- Valsartan
- Verapamil
- Ziprasidone
