Butabarbital

Butabarbital Brand Name– Butisol

What is Butabarbital

Butabarbital is an oral barbiturate with an intermediate duration of action. It is similar to amobarbital.

Butabarbital is clinically used for daytime sedation, to relieve preoperative anxiety and provide sedation, and in the short-term treatment of insomnia.

Butabarbital was approved by the FDA in June 1939.

Indications

1. anxiety
2. insomnia
3. procedural sedation
4. sedation maintenance

Side Effects

1. acneiform rash
2. agitation
3. anaphylactoid reactions
4. angioedema
5. anxiety
6. apnea
7. ataxia
8. bradycardia
9. bullous rash
10. complex sleep-related behaviors
11. confusion
12. constipation
13. depression
14. dizziness
15. drowsiness
16. dyspnea
17. exfoliative dermatitis
18. fever
19. hallucinations
20. headache
21. hyperkinesis
22. hypotension
23. hypoventilation
24. insomnia
25. maculopapular rash
26. miosis
27. mydriasis
28. nausea
29. nightmares
30. nystagmus
31. osteopenia
32. photosensitivity
33. physiological dependence
34. psychomotor impairment
35. ptosis
36. purpura
37. rash
38. respiratory depression
39. somnambulism
40. Stevens-Johnson syndrome
41. syncope
42. toxic epidermal necrolysis
43. urticaria
44. vertigo
45. vomiting
46. withdrawal

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• agranulocytosis
• alcoholism
• anticoagulant therapy
• asthma
• barbiturate hypersensitivity
• breast-feeding
• carbamazepine hypersensitivity
• cardiac disease
• children
• chronic obstructive pulmonary disease (COPD)
• CNS depression
• coadministration with other CNS depressants
• complex sleep-related behaviors
• depression
• driving or operating machinery
• ethanol ingestion
• exfoliative dermatitis
• geriatric
• hepatic disease
• hepatic encephalopathy
• hydantoin hypersensitivity
• hypotension
• infants
• labor
• mental status changes
• neonates
• obstetric delivery
• osteomalacia
• osteoporosis
• pain
• porphyria
• pregnancy
• pulmonary disease
• renal disease
• renal failure
• renal impairment
• respiratory depression
• seizure disorder
• seizures
• sleep apnea
• status asthmaticus
• status epilepticus
• substance abuse
• suicidal ideation
• tartrazine dye hypersensitivity

Interactions

• Abemaciclib
• Acetaminophen
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Acetazolamide
• Acrivastine; Pseudoephedrine
• Aldesleukin, IL-2
• Alfentanil
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alprazolam
• Altretamine
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminosalicylate sodium, Aminosalicylic acid
• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amoxapine
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amprenavir
• Anagrelide
• Apomorphine
• Apraclonidine
• Apremilast
• Aprepitant, Fosaprepitant
• Aripiprazole
• Armodafinil
• Artemether; Lumefantrine
• Asenapine
• Aspirin, ASA
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Aspirin, ASA; Dipyridamole
• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Oxycodone
• Aspirin, ASA; Pravastatin
• Atenolol; Chlorthalidone
• Atorvastatin
• Atorvastatin; Ezetimibe
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Avanafil
• Avapritinib
• Avatrombopag
• Axitinib
• Azelastine
• Azelastine; Fluticasone
• Azilsartan; Chlorthalidone
• Bedaquiline
• Belladonna; Opium
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendamustine
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benztropine
• Betaxolol
• Bicalutamide
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bortezomib
• Brexpiprazole
• Brigatinib
• Brimonidine
• Brimonidine; Brinzolamide
• Brimonidine; Timolol
• Brivaracetam
• Bromocriptine
• Brompheniramine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Budesonide
• Budesonide; Formoterol
• Bupivacaine
• Bupivacaine Liposomal
• Bupivacaine; Lidocaine
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butorphanol
• Caffeine
• Caffeine; Ergotamine
• Calcifediol
• Calcitriol
• Candesartan; Hydrochlorothiazide, HCTZ
• Cannabidiol
• Capmatinib
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cardiac glycosides
• Cariprazine
• Cenobamate
• Cetirizine
• Cetirizine; Pseudoephedrine
• Cevimeline
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlorambucil
• Chloramphenicol
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chlorothiazide
• Chlorpheniramine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Choline Salicylate; Magnesium Salicylate
• Cinacalcet
• Citalopram
• Clemastine
• Clobazam
• Clonazepam
• Clorazepate
• Clozapine
• Cobimetinib
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
• Conjugated Estrogens
• Conjugated Estrogens; Bazedoxifene
• Conjugated Estrogens; Medroxyprogesterone
• Cyclophosphamide
• Cyclosporine
• Cyproheptadine
• Darifenacin
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Deflazacort
• Delavirdine
• Deutetrabenazine
• Dexamethasone
• Dexchlorpheniramine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmedetomidine
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Quinidine
• Diazepam
• Diclofenac
• Diclofenac; Misoprostol
• Dienogest; Estradiol valerate
• Diethylstilbestrol, DES
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diltiazem
• Dimenhydrinate
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Disopyramide
• Dolutegravir; Rilpivirine
• Donepezil
• Donepezil; Memantine
• Doravirine
• Doravirine; Lamivudine; Tenofovir disoproxil fumarate
• Doxercalciferol
• Doxorubicin
• Doxycycline
• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
• Dronedarone
• Droperidol
• Drospirenone; Estradiol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elagolix; Estradiol; Norethindrone acetate
• Elbasvir; Grazoprevir
• Eltrombopag
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Entacapone
• Eprosartan; Hydrochlorothiazide, HCTZ
• Erdafitinib
• Erlotinib
• Escitalopram
• Esketamine
• Eslicarbazepine
• Esomeprazole
• Esomeprazole; Naproxen
• Estazolam
• Esterified Estrogens
• Esterified Estrogens; Methyltestosterone
• Estradiol
• Estradiol Cypionate; Medroxyprogesterone
• Estradiol; Levonorgestrel
• Estradiol; Norethindrone
• Estradiol; Norgestimate
• Estradiol; Progesterone
• Estrogens
• Estropipate
• Eszopiclone
• Ethanol
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Ethosuximide
• Ezetimibe; Simvastatin
• Fedratinib
• Felodipine
• Fenoprofen
• Fentanyl
• Flibanserin
• Fluconazole
• Fluoxetine; Olanzapine
• Fluticasone
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• food
• Fosamprenavir
• Fosinopril; Hydrochlorothiazide, HCTZ
• Gabapentin
• Galantamine
• Gallium Ga 68 Dotatate
• General anesthetics
• Glasdegib
• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Green Tea
• Griseofulvin
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guanfacine
• Haloperidol
• Hemin
• Homatropine; Hydrocodone
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hydroxyzine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Ifosfamide
• Iloperidone
• Imatinib
• Indinavir
• Isocarboxazid
• Isradipine
• Itraconazole
• Ivabradine
• Ixabepilone
• Ketoconazole
• Lansoprazole
• Lansoprazole; Naproxen
• Lasmiditan
• Lefamulin
• Lemborexant
• Lesinurad
• Lesinurad; Allopurinol
• Leucovorin
• Levobupivacaine
• Levocetirizine
• Levoleucovorin
• Levorphanol
• Linagliptin
• Linagliptin; Metformin
• Lithium
• Lofexidine
• Lopinavir; Ritonavir
• Lorazepam
• Lorlatinib
• Lovastatin
• Lovastatin; Niacin
• Loxapine
• Lumateperone
• Lurasidone
• Lurbinectedin
• Magnesium Salicylate
• Magnesium Salts
• Mannitol
• Maprotiline
• Mebendazole
• Meclizine
• Mefloquine
• Melatonin
• Meperidine
• Meperidine; Promethazine
• Meprobamate
• Mestranol; Norethindrone
• Metformin; Repaglinide
• Methadone
• Methazolamide
• Methocarbamol
• Methscopolamine
• Methsuximide
• Methyclothiazide
• Methylprednisolone
• Metoclopramide
• Metolazone
• Metronidazole
• Metyrapone
• Metyrosine
• Mexiletine
• Midazolam
• Minocycline
• Mirtazapine
• Mitotane
• Modafinil
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nalbuphine
• Nanoparticle Albumin-Bound Paclitaxel
• Nelfinavir
• Neratinib
• Nevirapine
• Niacin; Simvastatin
• Nicardipine
• Nifedipine
• Nimodipine
• Nintedanib
• Nisoldipine
• Olanzapine
• Olaparib
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole
• Omeprazole; Amoxicillin; Rifabutin
• Omeprazole; Sodium Bicarbonate
• Ondansetron
• Oxazepam
• Oxybutynin
• Oxycodone
• Oxymorphone
• Paclitaxel
• Paliperidone
• Papaverine
• Paroxetine
• Pemigatinib
• Pentazocine
• Pentazocine; Naloxone
• Perampanel
• Perindopril; Amlodipine
• Phenelzine
• Phenothiazines
• Phentermine; Topiramate
• Pimavanserin
• Pomalidomide
• Pralidoxime
• Pramipexole
• Prednisolone
• Prednisone
• Pregabalin
• Procarbazine
• Progestins
• Quazepam
• Quetiapine
• Quinidine
• Quinine
• Rabeprazole
• Ramelteon
• Ranolazine
• Rasagiline
• Red Yeast Rice
• Remifentanil
• Repaglinide
• Reserpine
• Rifapentine
• Rilpivirine
• Riluzole
• Rimegepant
• Risperidone
• Ritonavir
• Roflumilast
• Romidepsin
• Ropinirole
• Rotigotine
• Safinamide
• Salicylates
• Salsalate
• Saquinavir
• Scopolamine
• Segesterone Acetate; Ethinyl Estradiol
• Selegiline
• Selpercatinib
• Selumetinib
• Sertraline
• Sildenafil
• Simvastatin
• Simvastatin; Sitagliptin
• Sirolimus
• Skeletal Muscle Relaxants
• Sodium Oxybate
• Spironolactone
• Sufentanil
• Sunitinib
• Suvorexant
• Tacrolimus
• Tapentadol
• Tasimelteon
• Tazemetostat
• Temazepam
• Terbinafine
• Tetrabenazine
• Thalidomide
• Theophylline, Aminophylline
• Thiazide diuretics
• Thiothixene
• Thyroid hormones
• Tipranavir
• Tizanidine
• Tolcapone
• Topiramate
• Tramadol
• Trandolapril; Verapamil
• Tranylcypromine
• Trazodone
• Tretinoin, ATRA
• Triamcinolone
• Triazolam
• Tricyclic antidepressants
• Trimethobenzamide
• Trimetrexate
• Triprolidine
• Ubrogepant
• Ulipristal
• Valbenazine
• Valerian, Valeriana officinalis
• Valproic Acid, Divalproex Sodium
• Verapamil
• Vigabatrin
• Vincristine
• Vincristine Liposomal
• Vorapaxar
• Vortioxetine
• Voxelotor
• Warfarin
• Zaleplon
• Zanubrutinib
• Ziconotide
• Ziprasidone
• Zolpidem
• Zonisamide