Butenafine

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Butenafine Brand Names

Lotrimin | Mentax | Mentax -TC

What is Butenafine

Butenafine is a topical antifungal agent. Butenafine is a benzylamine antifungal derivative, which is structurally similar to the allylamines (e.g., naftifine and terbinafine).

Butenafine is active against a variety of superficial dermatophytes responsible for causing tinea pedis, tinea corporis, and tinea cruris.

The products contain 10 mg butenafine HCl per gram of the cream vehicle. The FDA approved butenafine in October 1996.

Indications

  1. Candida albicans
  2. Candida sp.
  3. Epidermophyton floccosum
  4. Malassezia furfur
  5. Microsporum canis
  6. tinea corporis
  7. tinea cruris
  8. tinea pedis
  9. tinea versicolor
  10. Trichophyton mentagrophytes
  11. Trichophyton rubrum
  12. Trichophyton tonsurans
  13. Trichophyton violaceum

Side Effects

  1. contact dermatitis
  2. erythema
  3. pruritus
  4. skin irritation

Topical administration of butenafine cream is associated with local adverse effects (< 2%), which most commonly include pruritus, burning, skin irritation, contact dermatitis, and erythema.

Other adverse events reported in approximately 1% of patients include burning, stinging, and worsening of the condition.

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • children
  • infants
  • neonates
  • ocular exposure
  • onychomycosis
  • ophthalmic administration
  • pregnancy
  • vaginal administration

Interactions

There are no drug interactions associated with Butenafine products.

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