Buspirone Brand Name– BuSpar
What is Buspirone
Buspirone is an orally administered anxiolytic that is structurally and pharmacologically distinct from all other anxiolytics including benzodiazepines and barbiturates.
Buspirone also differs from other anxiolytics in that it does not possess anticonvulsant or muscle-relaxant properties, does not impair psychomotor function, and does not cause physical dependence.
Thus, an advantage of buspirone versus benzodiazepine anxiolytics is that buspirone does not usually cause sedation or impact attentiveness.
Buspirone is not used for immediate relief because its onset of anxiolytic effects can be as long as 2 weeks.
The clinical use of buspirone is for the treatment of generalized anxiety disorder (GAD) in adults; while used clinically off-label in children and adolescents 6 years of age and older with anxiety, the efficacy of buspirone vs. placebo in pediatric patients for GAD has not been established in clinical trials.
Buspirone was first approved by the FDA in 1986.
Indications
- anxiety
- generalized anxiety disorder (GAD)
For the treatment of generalized anxiety disorder (GAD) or for the short-term relief of the symptoms of anxiety
Side Effects
- acne vulgaris
- akathisia
- alopecia
- amenorrhea
- angioedema
- anorexia
- appetite stimulation
- arthralgia
- ataxia
- bleeding
- blurred vision
- bradycardia
- cardiomyopathy
- chest pain (unspecified)
- confusion
- conjunctivitis
- diarrhea
- dizziness
- drowsiness
- dysarthria
- dysgeusia
- dysphoria
- dyspnea
- dystonic reaction
- dysuria
- ecchymosis
- edema
- ejaculation dysfunction
- elevated hepatic enzymes
- emotional lability
- eosinophilia
- epistaxis
- euphoria
- excitability
- fatigue
- fever
- flatulence
- flushing
- galactorrhea
- GI bleeding
- hallucinations
- headache
- heart failure
- hematoma
- hiccups
- hostility
- hyperhidrosis
- hypersalivation
- hypertension
- hyperventilation
- hypotension
- impotence (erectile dysfunction)
- increased urinary frequency
- insomnia
- involuntary movements
- leukopenia
- libido decrease
- libido increase
- malaise
- menstrual irregularity
- muscle cramps
- musculoskeletal pain
- myalgia
- myasthenia
- myocardial infarction
- nasal congestion
- nausea
- nocturia
- ocular pain
- ocular pruritus
- paresthesias
- parosmia
- photophobia
- pruritus
- pseudoparkinsonism
- psychosis
- rash
- restless legs syndrome (RLS)
- restlessness
- seizures
- serotonin syndrome
- stroke
- suicidal ideation
- syncope
- thrombocytopenia
- tinnitus
- tremor
- urinary retention
- urticaria
- vertigo
- visual impairment
- weakness
- weight gain
- weight loss
- xerosis
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- akathisia
- benzodiazepine dependence
- breast-feeding
- children
- driving or operating machinery
- ethanol ingestion
- geriatric
- hepatic disease
- infants
- MAOI therapy
- pregnancy
- renal failure
- renal impairment
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alfentanil
- Alprazolam
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
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- Amprenavir
- Apalutamide
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
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- Atazanavir; Cobicistat
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- atypical antipsychotic
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- Brigatinib
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Butabarbital
- Butorphanol
- Capsaicin; Metaxalone
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Cenobamate
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloral Hydrate
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorzoxazone
- Cimetidine
- Ciprofloxacin
- Citalopram
- Clarithromycin
- Clemastine
- Clobazam
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
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- Dexamethasone
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- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Diazepam
- Dicyclomine
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Duloxetine
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
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- Elagolix
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- Encorafenib
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Estazolam
- Eszopiclone
- Ethotoin
- Fedratinib
- Fentanyl
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluvoxamine
- food
- Fosamprenavir
- Fosphenytoin
- General anesthetics
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydantoins
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Idelalisib
- Iloperidone
- Imatinib
- Imipramine
- Indinavir
- Isavuconazonium
- Isocarboxazid
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lasmiditan
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- Lesinurad
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- Lorazepam
- Lorlatinib
- Loxapine
- Lumacaftor; Ivacaftor
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- Lurasidone
- Maprotiline
- Meclizine
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Mesoridazine
- Metaxalone
- Methadone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
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- Metoclopramide
- Midazolam
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- Palbociclib
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- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
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- Phenothiazines
- Phentermine; Topiramate
- Phenylephrine; Promethazine
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- Propoxyphene
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