Buspirone

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Buspirone Brand Name– BuSpar

What is Buspirone

Buspirone is an orally administered anxiolytic that is structurally and pharmacologically distinct from all other anxiolytics including benzodiazepines and barbiturates.

Buspirone also differs from other anxiolytics in that it does not possess anticonvulsant or muscle-relaxant properties, does not impair psychomotor function, and does not cause physical dependence.

Thus, an advantage of buspirone versus benzodiazepine anxiolytics is that buspirone does not usually cause sedation or impact attentiveness.

Buspirone is not used for immediate relief because its onset of anxiolytic effects can be as long as 2 weeks.

The clinical use of buspirone is for the treatment of generalized anxiety disorder (GAD) in adults; while used clinically off-label in children and adolescents 6 years of age and older with anxiety, the efficacy of buspirone vs. placebo in pediatric patients for GAD has not been established in clinical trials.

Buspirone was first approved by the FDA in 1986.

Indications

  • anxiety
  • generalized anxiety disorder (GAD)

For the treatment of generalized anxiety disorder (GAD) or for the short-term relief of the symptoms of anxiety

Side Effects

  1. acne vulgaris
  2. akathisia
  3. alopecia
  4. amenorrhea
  5. angioedema
  6. anorexia
  7. appetite stimulation
  8. arthralgia
  9. ataxia
  10. bleeding
  11. blurred vision
  12. bradycardia
  13. cardiomyopathy
  14. chest pain (unspecified)
  15. confusion
  16. conjunctivitis
  17. diarrhea
  18. dizziness
  19. drowsiness
  20. dysarthria
  21. dysgeusia
  22. dysphoria
  23. dyspnea
  24. dystonic reaction
  25. dysuria
  26. ecchymosis
  27. edema
  28. ejaculation dysfunction
  29. elevated hepatic enzymes
  30. emotional lability
  31. eosinophilia
  32. epistaxis
  33. euphoria
  34. excitability
  35. fatigue
  36. fever
  37. flatulence
  38. flushing
  39. galactorrhea
  40. GI bleeding
  41. hallucinations
  42. headache
  43. heart failure
  44. hematoma
  45. hiccups
  46. hostility
  47. hyperhidrosis
  48. hypersalivation
  49. hypertension
  50. hyperventilation
  51. hypotension
  52. impotence (erectile dysfunction)
  53. increased urinary frequency
  54. insomnia
  55. involuntary movements
  56. leukopenia
  57. libido decrease
  58. libido increase
  59. malaise
  60. menstrual irregularity
  61. muscle cramps
  62. musculoskeletal pain
  63. myalgia
  64. myasthenia
  65. myocardial infarction
  66. nasal congestion
  67. nausea
  68. nocturia
  69. ocular pain
  70. ocular pruritus
  71. paresthesias
  72. parosmia
  73. photophobia
  74. pruritus
  75. pseudoparkinsonism
  76. psychosis
  77. rash
  78. restless legs syndrome (RLS)
  79. restlessness
  80. seizures
  81. serotonin syndrome
  82. stroke
  83. suicidal ideation
  84. syncope
  85. thrombocytopenia
  86. tinnitus
  87. tremor
  88. urinary retention
  89. urticaria
  90. vertigo
  91. visual impairment
  92. weakness
  93. weight gain
  94. weight loss
  95. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • akathisia
  • benzodiazepine dependence
  • breast-feeding
  • children
  • driving or operating machinery
  • ethanol ingestion
  • geriatric
  • hepatic disease
  • infants
  • MAOI therapy
  • pregnancy
  • renal failure
  • renal impairment

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acrivastine; Pseudoephedrine
  • Aldesleukin, IL-2
  • Alfentanil
  • Alprazolam
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amobarbital
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamines
  • Amprenavir
  • Apalutamide
  • Apomorphine
  • Apraclonidine
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • atypical antipsychotic
  • Azelastine
  • Azelastine; Fluticasone
  • Baclofen
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Boceprevir
  • Brexpiprazole
  • Brigatinib
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Butabarbital
  • Butorphanol
  • Capsaicin; Metaxalone
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Carisoprodol
  • Cenobamate
  • Ceritinib
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chloral Hydrate
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorzoxazone
  • Cimetidine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clemastine
  • Clobazam
  • Clomipramine
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Crizotinib
  • Cyclizine
  • Cyclobenzaprine
  • Cyproheptadine
  • Dabrafenib
  • Danazol
  • Dantrolene
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Desipramine
  • Desvenlafaxine
  • Dexamethasone
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Promethazine
  • Diazepam
  • Dicyclomine
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doxepin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Duloxetine
  • Duvelisib
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix
  • Elbasvir; Grazoprevir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Encorafenib
  • Enzalutamide
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Estazolam
  • Eszopiclone
  • Ethotoin
  • Fedratinib
  • Fentanyl
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Fluvoxamine
  • food
  • Fosamprenavir
  • Fosphenytoin
  • General anesthetics
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Idelalisib
  • Iloperidone
  • Imatinib
  • Imipramine
  • Indinavir
  • Isavuconazonium
  • Isocarboxazid
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ivosidenib
  • Ketoconazole
  • Lasmiditan
  • Lefamulin
  • Lesinurad
  • Lesinurad; Allopurinol
  • Letermovir
  • Levocetirizine
  • Levomethadyl
  • Levomilnacipran
  • Levorphanol
  • Linezolid
  • Lithium
  • Lopinavir; Ritonavir
  • Lorazepam
  • Lorlatinib
  • Loxapine
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Lurasidone
  • Maprotiline
  • Meclizine
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Mesoridazine
  • Metaxalone
  • Methadone
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
  • Methscopolamine
  • Methylene Blue
  • Metoclopramide
  • Midazolam
  • Mifepristone
  • Milnacipran
  • Mirtazapine
  • Mitotane
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nefazodone
  • Nelfinavir
  • Nicardipine
  • Nilotinib
  • Nortriptyline
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oritavancin
  • Orphenadrine
  • Oxazepam
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Palbociclib
  • Paliperidone
  • Papaverine
  • Paroxetine
  • Pazopanib
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenobarbital
  • Phenothiazines
  • Phentermine; Topiramate
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pimozide
  • Posaconazole
  • Pregabalin
  • Primidone
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propoxyphene
  • Protriptyline
  • Quazepam
  • Quetiapine
  • Ramelteon
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifampin
  • Risperidone
  • Ritonavir
  • Ropinirole
  • Rotigotine
  • Saquinavir
  • Secobarbital
  • Sedating H1-blockers
  • Selegiline
  • Serotonin norepinephrine reuptake inhibitors
  • Serotonin-Receptor Agonists
  • Sertraline
  • Sibutramine
  • Simeprevir
  • Skeletal Muscle Relaxants
  • Sodium Oxybate
  • Sufentanil
  • Tapentadol
  • Tedizolid
  • Telaprevir
  • Telithromycin
  • Telotristat Ethyl
  • Temazepam
  • Tetrabenazine
  • Thalidomide
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Tipranavir
  • Tizanidine
  • Topiramate
  • Tramadol
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trazodone
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimethobenzamide
  • Trimipramine
  • Triprolidine
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vigabatrin
  • Vilazodone
  • Voriconazole
  • Vortioxetine
  • Zafirlukast
  • Zaleplon
  • Ziconotide
  • Zileuton
  • Ziprasidone
  • Zolpidem

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