Brompheniramine Hydrocodone Pseudoephedrine

Brompheniramine Hydrocodone Pseudoephedrine Brand Names

Anaplex HD | Bromcomp HC | Bromphenex HD | Bromplex HD | BroveX HC | Drocon CS | EndaCof-HC | M-End | SymTan A

What is Brompheniramine Hydrocodone Pseudoephedrine

NOTE: These products are discontinued in the U.S.

Brompheniramine hydrocodone pseudoephedrine are used together in an oral preparation to relieve cough and congestion and to facilitate bronchial and sinus drainage.

This combination is indicated for the relief of nasal congestion and dry, non-productive cough associated with the common cold, influenza, sinusitis, or bronchitis.

Brompheniramine is a first-generation sedating antihistamine (H1-blocker) of the propylamine class that dries nasal and sinus passages. Hydrocodone, similar to codeine, is an opiate antitussive used for cough suppression.

The antitussive and sedative properties of hydrocodone are greater than codeine. Hydrocodone also has analgesic properties, although it is not used for this purpose when combined with brompheniramine and pseudoephedrine.

Pseudoephedrine is a sympathomimetic agent that stimulates alpha₁-adrenergic receptors in vascular smooth muscle.

This causes vasoconstriction, resulting in shrinkage of nasal mucous membranes, reduction of tissue hyperemia and edema, and an increase in nasal airway patency leading to decreased congestion.

Indications

1. common cold
2. cough
3. eustachian tube congestion
4. nasal congestion

For the relief of cough and upper respiratory congestion (nasal congestion and eustachian tube congestion) due to the common cold and acute respiratory infections (e.g., influenza, sinusitis, and bronchitis)

Side Effects

1. abdominal pain
2. angina
3. anorexia
4. anxiety
5. arrhythmia exacerbation
6. blurred vision
7. confusion
8. constipation
9. delirium
10. diarrhea
11. diplopia
12. dizziness
13. drowsiness
14. dyskinesia
15. dyspepsia
16. dysphoria
17. dysuria
18. emotional lability
19. euphoria
20. excitability
21. headache
22. hypertension
23. hypotension
24. impaired cognition
25. impotence (erectile dysfunction)
26. insomnia
27. irritability
28. lethargy
29. mydriasis
30. myocardial infarction
31. nausea
32. palpitations
33. photophobia
34. premature ventricular contractions (PVCs)
35. pruritus
36. psychological dependence
37. rash
38. respiratory depression
39. restlessness
40. seizures
41. sinus tachycardia
42. stroke
43. supraventricular tachycardia (SVT)
44. tinnitus
45. tolerance
46. tremor
47. urinary retention
48. urticaria
49. vertigo
50. visual impairment
51. vomiting
52. weakness
53. withdrawal
54. xerophthalmia
55. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• acute abdomen
• acute myocardial infarction
• angina
• asthma
• bladder obstruction
• breast-feeding
• bronchitis
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• children
• closed-angle glaucoma
• constipation
• contact lenses
• coronary artery disease
• diabetes mellitus
• diarrhea
• driving or operating machinery
• emphysema
• geriatric
• GI obstruction
• head trauma
• hepatic disease
• hypertension
• hyperthyroidism
• ileus
• increased intracranial pressure
• infants
• labor
• MAOI therapy
• neonates
• opiate agonist hypersensitivity
• peptic ulcer disease
• pregnancy
• prostatic hypertrophy
• renal failure
• renal impairment
• seizure disorder
• status asthmaticus
• substance abuse
• tachycardia
• tobacco smoking
• ulcerative colitis
• urinary retention

Interactions

• Abiraterone
• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
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• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Doxylamine
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• Thiopental
• Thioridazine
• Thiothixene
• Thyroid hormones
• Ticagrelor
• Timolol
• Tipranavir
• Tizanidine
• Tolcapone
• Tolterodine
• Topiramate
• Torsemide
• Tramadol
• Trandolapril
• Trandolapril; Verapamil
• Tranylcypromine
• Trastuzumab; Hyaluronidase
• Trazodone
• Treprostinil
• Triamterene
• Triazolam
• Tricyclic antidepressants
• Trifluoperazine
• Trihexyphenidyl
• Trimethobenzamide
• Triprolidine
• Trospium
• Tucatinib
• Umeclidinium; Vilanterol
• Valerian, Valeriana officinalis
• Valproic Acid, Divalproex Sodium
• Vasodilators
• Vasopressors
• Vemurafenib
• Venlafaxine
• Verapamil
• Vigabatrin
• Vilazodone
• Voriconazole
• Vortioxetine
• Voxelotor
• Yohimbine
• Zafirlukast
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolmitriptan
• Zolpidem