Brompheniramine Carbetapentane Phenylephrine

Brompheniramine Carbetapentane Phenylephrine Brand Names

BetaTan | Pulmari | Seradex | Trexbrom | Vazotan | V-Cof

What is Brompheniramine Carbetapentane Phenylephrine

NOTE: These products are discontinued in the U.S.

Brompheniramine carbetapentane phenylephrine are used together for the relief of cough, nasal congestion, and rhinorrhea associated with the common cold, sinusitis, allergic rhinitis, and other upper respiratory tract conditions.

Brompheniramine is a first generation, sedating antihistamine (H1-blocker) of the propylamine class commonly used for treating symptoms related to histamine release such as rhinorrhea.

Antihistamines from the propylamine group generally have a more potent antihistamine effect and less sedation and antiemetic effects than antihistamines from the ethanolamine group (e.g., diphenhydramine).

Carbetapentane is a non-opioid, centrally-acting cough suppressant. The cough suppressant effect of carbetapentane is less potent than opiates; however, unlike opiates, carbetapentane has not been associated with substance abuse.

Phenylephrine is a sympathomimetic amine used as a decongestant to decrease nasal and sinus congestion.

Phenylephrine appears to have a lower propensity to cause hypertension and potential sequelae (e.g., stroke, hypertensive crisis, intracranial bleeding) than ephedrine or phenylpropanolamine.

Brompheniramine arbetapentane phenylephrine is available by prescription in formulations for adults and children.

Indications

1. allergic rhinitis
2. common cold
3. cough
4. nasal congestion
5. rhinorrhea
6. sinusitis

For relief of cough, nasal congestion, and rhinorrhea associated with the common cold, sinusitis, allergic rhinitis, or other upper respiratory tract conditions

Side Effects

1. agranulocytosis
2. anaphylactic shock
3. angina
4. anorexia
5. anxiety
6. apnea
7. arrhythmia exacerbation
8. ataxia
9. blurred vision
10. bronchial secretions
11. confusion
12. constipation
13. diaphoresis
14. diarrhea
15. diplopia
16. dizziness
17. drowsiness
18. dyspepsia
19. dysuria
20. euphoria
21. excitability
22. fatigue
23. hallucinations
24. headache
25. hemolytic anemia
26. hypertension
27. hypertensive crisis
28. hypotension
29. hypotonia
30. insomnia
31. irritability
32. leukopenia
33. mydriasis
34. myocardial infarction
35. nausea
36. neuritis
37. pallor
38. palpitations
39. paresthesias
40. photophobia
41. photosensitivity
42. polyuria
43. premature ventricular contractions (PVCs)
44. pruritus
45. psychosis
46. rash
47. respiratory depression
48. restlessness
49. seizures
50. sinus tachycardia
51. stroke
52. supraventricular tachycardia (SVT)
53. thrombocytopenia
54. tinnitus
55. tremor
56. urinary retention
57. urticaria
58. vertigo
59. visual impairment
60. vomiting
61. xerophthalmia
62. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• acute myocardial infarction
• aneurysm
• angina
• arteriosclerosis
• asthma
• atrial fibrillation
• atrial flutter
• AV block
• bladder obstruction
• bradycardia
• breast-feeding
• bronchitis
• bundle-branch block
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• cerebrovascular disease
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• constipation
• contact lenses
• coronary artery disease
• diabetes mellitus
• driving or operating machinery
• emphysema
• geriatric
• GI disease
• GI obstruction
• head trauma
• heart failure
• hepatic disease
• hypertension
• hyperthyroidism
• ileus
• increased intracranial pressure
• increased intraocular pressure
• infants
• intracranial bleeding
• labor
• MAOI therapy
• myocardial infarction
• neonates
• obstetric delivery
• organic brain syndrome
• peptic ulcer disease
• peripheral vascular disease
• phenylketonuria
• pregnancy
• prostatic hypertrophy
• pulmonary disease
• pyloric stenosis
• renal disease
• renal failure
• renal impairment
• seizure disorder
• status asthmaticus
• stroke
• tachycardia
• thyrotoxicosis
• tobacco smoking
• ulcerative colitis
• urinary retention
• ventricular fibrillation
• ventricular tachycardia

Interactions

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