Brompheniramine

Brompheniramine Brand Names

Bidhist | Bromax | BroveX | BroveX CT | B-Vex | J-Tan | J-Tan PD | Lodrane | Lodrane XR | LoHist-12 | Respa-BR | TanaCof-XR | Vazol

What is Brompheniramine

Brompheniramine is a sedating antihistamine (H1-blocker) of the propylamine class.

Brompheniramine has a strong antihistaminic effect, moderate anticholinergic effect, and no antiemetic effect.

Brompheniramine is used in the treatment of allergic conjunctivitis and rhinitis, angioedema, pruritus, urticaria and other allergic or histamine-mediated reactions.

Brompheniramine was initially marketed for use before 1962 and prior to the modern FDA drug-approval process requiring demonstration of safety and efficacy. A parenteral formulation was previously commercially available, but is no longer marketed.

Indications

1. allergic conjunctivitis
2. allergic rhinitis
3. anaphylaxis
4. angioedema
5. common cold
6. dermatographism
7. pruritus
8. rhinorrhea
9. sneezing
10. urticaria
11. vasomotor rhinitis

Side Effects

1. abdominal pain
2. angina
3. anorexia
4. anxiety
5. arrhythmia exacerbation
6. AV block
7. blurred vision
8. confusion
9. constipation
10. delirium
11. diarrhea
12. diplopia
13. dizziness
14. drowsiness
15. dyskinesia
16. dyspepsia
17. dysuria
18. euphoria
19. excitability
20. hyperhidrosis
21. hypertension
22. hypotension
23. impotence (erectile dysfunction)
24. insomnia
25. irritability
26. lethargy
27. menstrual irregularity
28. mydriasis
29. nasal congestion
30. nausea
31. palpitations
32. paresthesias
33. polyuria
34. psychosis
35. pyrosis (heartburn)
36. rash
37. restlessness
38. seizures
39. sinus tachycardia
40. tinnitus
41. tremor
42. urinary retention
43. vertigo
44. visual impairment
45. vomiting
46. weakness
47. wheezing
48. xerophthalmia
49. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• anticholinergic medications
• asthma
• bladder obstruction
• breast-feeding
• bronchitis
• cardiac disease
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• coadministration with other CNS depressants
• contact lenses
• driving or operating machinery
• emphysema
• ethanol ingestion
• geriatric
• GI obstruction
• hepatic disease
• hypertension
• hyperthyroidism
• ileus
• increased intraocular pressure
• infants
• MAOI therapy
• neonates
• pregnancy
• prostatic hypertrophy
• seizure disorder
• status asthmaticus
• urinary retention

Interactions

• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Codeine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Alfentanil
• Alosetron
• Amantadine
• Ambenonium Chloride
• Amobarbital
• Amoxapine
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Anticholinergics
• Apomorphine
• Aripiprazole
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azelastine
• Azelastine; Fluticasone
• Baclofen
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benzhydrocodone; Acetaminophen
• Benzodiazepines
• Benzphetamine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Buprenorphine
• Buprenorphine; Naloxone
• Buspirone
• Butabarbital
• Butorphanol
• Cannabidiol
• Capsaicin; Metaxalone
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carisoprodol
• Cenobamate
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpromazine
• Chlorzoxazone
• Clobazam
• Clozapine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
• Cyclobenzaprine
• Dantrolene
• Daratumumab; Hyaluronidase
• Desloratadine
• Desloratadine; Pseudoephedrine
• Deutetrabenazine
• Dexmedetomidine
• Dextroamphetamine
• Dextromethorphan; Promethazine
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Disopyramide
• Donepezil
• Donepezil; Memantine
• Dronabinol
• Droperidol
• Entacapone
• Esketamine
• Eszopiclone
• Ethanol
• Etomidate
• Ezogabine
• Fentanyl
• Flibanserin
• Fluoxetine; Olanzapine
• Fluphenazine
• Fospropofol
• Gabapentin
• Galantamine
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Halogenated Anesthetics
• Haloperidol
• Heparin
• Homatropine; Hydrocodone
• Hyaluronidase
• Hyaluronidase, Recombinant; Immune Globulin
• Hydantoins
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Ibuprofen; Oxycodone
• Iloperidone
• Isocarboxazid
• Ketamine
• Lasmiditan
• Lemborexant
• Levocetirizine
• Levomethadyl
• Levorphanol
• Lithium
• Lofexidine
• Loratadine
• Loratadine; Pseudoephedrine
• Loxapine
• Lumateperone
• Lurasidone
• Magnesium Salts
• Maprotiline
• Meclizine
• Melatonin
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Metaxalone
• Methadone
• Methamphetamine
• Methocarbamol
• Methohexital
• Metoclopramide
• Metyrapone
• Metyrosine
• Minocycline
• Mirtazapine
• Mitotane
• Molindone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nalbuphine
• Nefazodone
• Olanzapine
• Opiate Agonists
• Orphenadrine
• Oxycodone
• Oxymorphone
• Paliperidone
• Paroxetine
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Perphenazine
• Perphenazine; Amitriptyline
• Phenelzine
• Phenobarbital
• Phenylephrine; Promethazine
• Pimozide
• Pitolisant
• Pramipexole
• Pregabalin
• Primidone
• Procarbazine
• Prochlorperazine
• Promethazine
• Propofol
• Propoxyphene
• Quetiapine
• Ramelteon
• Rasagiline
• Remifentanil
• Risperidone
• Rituximab; Hyaluronidase
• Rivastigmine
• Ropinirole
• Safinamide
• Secobarbital
• Selegiline
• Sincalide
• Sodium Iodide
• Solifenacin
• Sufentanil
• Suvorexant
• Tacrine
• Tapentadol
• Tasimelteon
• Thalidomide
• Thiopental
• Thioridazine
• Thiothixene
• Tizanidine
• Tolcapone
• Tramadol
• Tranylcypromine
• Trastuzumab; Hyaluronidase
• Trazodone
• Tricyclic antidepressants
• Trifluoperazine
• Trimethobenzamide
• Trospium
• Vigabatrin
• Vilazodone
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolpidem