Brodalumab Brand Name– SILIQ
What is Brodalumab
Brodalumab is an injectable human IgG2 monoclonal antibody that binds to interleukin-17 receptor A (IL-17RA), and prevents IL-17 cytokines from activating the receptor.
Brodalumab is used to treat adults with moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy (UV light treatment) and have failed to respond, or have stopped responding to other systemic therapies.
Suicidal ideation and behavior, including completed suicides, have occurred in patients treated with the drug during clinical trials. Patients with a history of suicidality or depression had an increased incidence risk for these events during treatment.
A causal association between treatment with the drug and increased risk of suicidal ideation and behavior has not been established.
Because of the observed risk of suicidal ideation and behavior, the labeling includes a Boxed Warning and the drug is only available through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS), the SILIQ REMS Program.
The FDA approved brodalumab in February 2017.
Indications
- psoriasis
For the treatment of moderate to severe plaque psoriasis in patients who are candidates for systemic therapy or phototherapy and have failed to respond or have lost response to other systemic therapies
Side Effects
- antibody formation
- anxiety
- arthralgia
- bleeding
- depression
- diarrhea
- emotional lability
- erythema
- fatigue
- headache
- infection
- infection
- influenza
- injection site reaction
- meningitis
- myalgia
- nausea
- neutropenia
- pharyngitis
- pruritus
- suicidal ideation
Monitoring Parameters
- tuberculin skin test
Contraindications
- breast-feeding
- children
- Crohn’s disease
- depression
- fungal infection
- immunosuppression
- infants
- infection
- neonates
- pregnancy
- psychosis
- suicidal ideation
- tuberculosis
- vaccination
Interactions
- Bacillus Calmette-Guerin Vaccine, BCG
- Canakinumab
- Carbamazepine
- Cyclosporine
- Encorafenib
- Erdafitinib
- Ethosuximide
- Fosphenytoin
- Influenza Virus Vaccine
- Intranasal Influenza Vaccine
- Live Vaccines
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Phenytoin
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Smallpox and Monkeypox Vaccine, Live, Nonreplicating
- Smallpox Vaccine, Vaccinia Vaccine
- Tacrolimus
- Theophylline, Aminophylline
- Typhoid Vaccine
- Upadacitinib
- Varicella-Zoster Virus Vaccine, Live
- Warfarin
- Yellow Fever Vaccine, Live