Brodalumab

Brodalumab Brand Name– SILIQ

What is Brodalumab

Brodalumab is an injectable human IgG2 monoclonal antibody that binds to interleukin-17 receptor A (IL-17RA), and prevents IL-17 cytokines from activating the receptor.

Brodalumab is used to treat adults with moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy (UV light treatment) and have failed to respond, or have stopped responding to other systemic therapies.

Suicidal ideation and behavior, including completed suicides, have occurred in patients treated with the drug during clinical trials. Patients with a history of suicidality or depression had an increased incidence risk for these events during treatment.

A causal association between treatment with the drug and increased risk of suicidal ideation and behavior has not been established.

Because of the observed risk of suicidal ideation and behavior, the labeling includes a Boxed Warning and the drug is only available through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS), the SILIQ REMS Program.

The FDA approved brodalumab in February 2017.

Indications

  • psoriasis

For the treatment of moderate to severe plaque psoriasis in patients who are candidates for systemic therapy or phototherapy and have failed to respond or have lost response to other systemic therapies

Side Effects

  1. antibody formation
  2. anxiety
  3. arthralgia
  4. bleeding
  5. depression
  6. diarrhea
  7. emotional lability
  8. erythema
  9. fatigue
  10. headache
  11. infection
  12. infection
  13. influenza
  14. injection site reaction
  15. meningitis
  16. myalgia
  17. nausea
  18. neutropenia
  19. pharyngitis
  20. pruritus
  21. suicidal ideation

Monitoring Parameters

  • tuberculin skin test

Contraindications

  • breast-feeding
  • children
  • Crohn’s disease
  • depression
  • fungal infection
  • immunosuppression
  • infants
  • infection
  • neonates
  • pregnancy
  • psychosis
  • suicidal ideation
  • tuberculosis
  • vaccination

Interactions

  • Bacillus Calmette-Guerin Vaccine, BCG
  • Canakinumab
  • Carbamazepine
  • Cyclosporine
  • Encorafenib
  • Erdafitinib
  • Ethosuximide
  • Fosphenytoin
  • Influenza Virus Vaccine
  • Intranasal Influenza Vaccine
  • Live Vaccines
  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Measles/Mumps/Rubella Vaccines, MMR
  • Phenytoin
  • Rotavirus Vaccine
  • Rubella Virus Vaccine Live
  • Smallpox and Monkeypox Vaccine, Live, Nonreplicating
  • Smallpox Vaccine, Vaccinia Vaccine
  • Tacrolimus
  • Theophylline, Aminophylline
  • Typhoid Vaccine
  • Upadacitinib
  • Varicella-Zoster Virus Vaccine, Live
  • Warfarin
  • Yellow Fever Vaccine, Live
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