Bendroflumethiazide Nadolol Brand Name– Corzide
What is Bendroflumethiazide Nadolol
Bendroflumethiazide and nadolol are used together in an oral preparation to treat hypertension.
Bendroflumethiazide is a thiazide diuretic. Nadolol is an oral, nonselective, beta-adrenergic receptor antagonist similar to propranolol.
Nadolol does not demonstrate appreciable intrinsic sympathomimetic (ISA) or membrane-stabilizing (MSA)activities.
Unlike propranolol, nadolol is renally eliminated and possesses a low degree of lipid solubility and has the longest plasma half-life of all the beta-blockers.
The FDA-approved the combination of nadolol-bendroflumethazide in 1983.
Indications
- hypertension
For the treatment of hypertension in patients who do not respond to monotherapy
Side Effects
- abdominal pain
- agranulocytosis
- alopecia
- anorexia
- aplastic anemia
- AV block
- azotemia
- blurred vision
- bradycardia
- bronchospasm
- constipation
- depression
- diabetes mellitus
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dyspnea
- elevated hepatic enzymes
- emotional lability
- erythema multiforme
- exfoliative dermatitis
- fatigue
- fever
- flatulence
- gout
- hallucinations
- headache
- heart failure
- hemolytic anemia
- hyperbilirubinemia
- hypercalcemia
- hypercholesterolemia
- hyperglycemia
- hypertension
- hypertriglyceridemia
- hyperuricemia
- hypochloremia
- hypoglycemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypotension
- hypovolemia
- impotence (erectile dysfunction)
- interstitial nephritis
- jaundice
- leukopenia
- libido decrease
- memory impairment
- metabolic alkalosis
- muscle cramps
- nausea
- nephrolithiasis
- orthostatic hypotension
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- periarteritis
- peripheral vasoconstriction
- photosensitivity
- pruritus
- purpura
- rash
- renal failure (unspecified)
- sialadenitis
- sinus tachycardia
- Stevens-Johnson syndrome
- syncope
- thrombocytopenia
- toxic epidermal necrolysis
- tremor
- urticaria
- vertigo
- visual impairment
- vomiting
- wheezing
- withdrawal
- xanthopsia
- xerophthalmia
- xerosis
- xerostomia
Monitoring Parameters
- blood glucose
- blood pressure
- heart rate
- serum creatinine/BUN
- serum electrolytes
- serum uric acid
Contraindications
- abrupt discontinuation
- acid/base imbalance
- acute bronchospasm
- anuria
- asthma
- AV block
- beta-blocker hypersensitivity
- bradycardia
- breast-feeding
- bronchitis
- cardiogenic shock
- cerebrovascular disease
- children
- chronic obstructive pulmonary disease (COPD)
- depression
- diabetes mellitus
- driving or operating machinery
- electrolyte imbalance
- emphysema
- geriatric
- heart failure
- hepatic disease
- hypercalcemia
- hypercholesterolemia
- hyperglycemia
- hyperthyroidism
- hypertriglyceridemia
- hyperuricemia
- hypochloremia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypotension
- hypovolemia
- labor
- metabolic alkalosis
- myasthenia gravis
- obstetric delivery
- orthostatic hypotension
- pancreatitis
- peripheral vascular disease
- pheochromocytoma
- preeclampsia
- pregnancy
- psoriasis
- pulmonary disease
- pulmonary edema
- Raynaud’s phenomenon
- renal disease
- renal failure
- renal impairment
- sick sinus syndrome
- sulfonamide hypersensitivity
- sunlight (UV) exposure
- surgery
- sympathectomy
- syncope
- systemic lupus erythematosus (SLE)
- thiazide diuretic hypersensitivity
- thyroid disease
- vasospastic angina
- ventricular dysfunction
Interactions
- Acarbose
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
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- Acetazolamide
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- Allopurinol
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- Alpha-blockers
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- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
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- Aspirin, ASA; Caffeine; Orphenadrine
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- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
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- Chlorpropamide
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- Empagliflozin
- Empagliflozin; Linagliptin
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- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Encainide
- Enflurane
- Ephedrine
- Epinephrine
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- Fluvoxamine
- food
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- Fospropofol
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