Bendroflumethiazide Nadolol

Bendroflumethiazide Nadolol Brand Name– Corzide

What is Bendroflumethiazide Nadolol

Bendroflumethiazide and nadolol are used together in an oral preparation to treat hypertension.

Bendroflumethiazide is a thiazide diuretic. Nadolol is an oral, nonselective, beta-adrenergic receptor antagonist similar to propranolol.

Nadolol does not demonstrate appreciable intrinsic sympathomimetic (ISA) or membrane-stabilizing (MSA)activities.

Unlike propranolol, nadolol is renally eliminated and possesses a low degree of lipid solubility and has the longest plasma half-life of all the beta-blockers.

The FDA-approved the combination of nadolol-bendroflumethazide in 1983.

Indications

  • hypertension

For the treatment of hypertension in patients who do not respond to monotherapy

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. alopecia
  4. anorexia
  5. aplastic anemia
  6. AV block
  7. azotemia
  8. blurred vision
  9. bradycardia
  10. bronchospasm
  11. constipation
  12. depression
  13. diabetes mellitus
  14. diaphoresis
  15. diarrhea
  16. dizziness
  17. drowsiness
  18. dyspnea
  19. elevated hepatic enzymes
  20. emotional lability
  21. erythema multiforme
  22. exfoliative dermatitis
  23. fatigue
  24. fever
  25. flatulence
  26. gout
  27. hallucinations
  28. headache
  29. heart failure
  30. hemolytic anemia
  31. hyperbilirubinemia
  32. hypercalcemia
  33. hypercholesterolemia
  34. hyperglycemia
  35. hypertension
  36. hypertriglyceridemia
  37. hyperuricemia
  38. hypochloremia
  39. hypoglycemia
  40. hypokalemia
  41. hypomagnesemia
  42. hyponatremia
  43. hypotension
  44. hypovolemia
  45. impotence (erectile dysfunction)
  46. interstitial nephritis
  47. jaundice
  48. leukopenia
  49. libido decrease
  50. memory impairment
  51. metabolic alkalosis
  52. muscle cramps
  53. nausea
  54. nephrolithiasis
  55. orthostatic hypotension
  56. palpitations
  57. pancreatitis
  58. pancytopenia
  59. paresthesias
  60. periarteritis
  61. peripheral vasoconstriction
  62. photosensitivity
  63. pruritus
  64. purpura
  65. rash
  66. renal failure (unspecified)
  67. sialadenitis
  68. sinus tachycardia
  69. Stevens-Johnson syndrome
  70. syncope
  71. thrombocytopenia
  72. toxic epidermal necrolysis
  73. tremor
  74. urticaria
  75. vertigo
  76. visual impairment
  77. vomiting
  78. wheezing
  79. withdrawal
  80. xanthopsia
  81. xerophthalmia
  82. xerosis
  83. xerostomia

Monitoring Parameters

  • blood glucose
  • blood pressure
  • heart rate
  • serum creatinine/BUN
  • serum electrolytes
  • serum uric acid

Contraindications

  • abrupt discontinuation
  • acid/base imbalance
  • acute bronchospasm
  • anuria
  • asthma
  • AV block
  • beta-blocker hypersensitivity
  • bradycardia
  • breast-feeding
  • bronchitis
  • cardiogenic shock
  • cerebrovascular disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • depression
  • diabetes mellitus
  • driving or operating machinery
  • electrolyte imbalance
  • emphysema
  • geriatric
  • heart failure
  • hepatic disease
  • hypercalcemia
  • hypercholesterolemia
  • hyperglycemia
  • hyperthyroidism
  • hypertriglyceridemia
  • hyperuricemia
  • hypochloremia
  • hypokalemia
  • hypomagnesemia
  • hyponatremia
  • hypotension
  • hypovolemia
  • labor
  • metabolic alkalosis
  • myasthenia gravis
  • obstetric delivery
  • orthostatic hypotension
  • pancreatitis
  • peripheral vascular disease
  • pheochromocytoma
  • preeclampsia
  • pregnancy
  • psoriasis
  • pulmonary disease
  • pulmonary edema
  • Raynaud’s phenomenon
  • renal disease
  • renal failure
  • renal impairment
  • sick sinus syndrome
  • sulfonamide hypersensitivity
  • sunlight (UV) exposure
  • surgery
  • sympathectomy
  • syncope
  • systemic lupus erythematosus (SLE)
  • thiazide diuretic hypersensitivity
  • thyroid disease
  • vasospastic angina
  • ventricular dysfunction

Interactions

  • Acarbose
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  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
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  • food
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