Baclofen

Sharing is caring!

Baclofen Brand Names

BACLOFEN | ED Baclofen | EnovaRX | Equipto Baclofen | First-Baclofen | Gablofen | Lioresal | OZOBAX

What is Baclofen

Baclofen is an oral skeletal muscle relaxant. It is a structural analog of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).

Clinically, baclofen is used to treat spasticity and improve mobility in patients with multiple sclerosis and other spinal cord lesions by decreasing the number and severity of spasms and relieving associated pain, clonus, and muscle rigidity. Baclofen also improves bowel and bladder function in some of these patients.

Baclofen (Lioresal®) was approved by the FDA in November 1977.

In February 1995, the FDA granted approval under a treatment IND to use intrathecal baclofen (Lioresal® Intrathecal) for the treatment of spasticity of cerebral origin; full FDA approval was granted in 1997.

An orally-disentegrating tablet formulation (Kemstro™) was FDA-approved in late 2003; however, the product was never commercially launched in the U.S. by the manufacturer.

Indications

  1. gastroesophageal reflux disease (GERD)
  2. multiple sclerosis
  3. muscle spasm
  4. nystagmus
  5. singultus (hiccups)
  6. spasticity
  7. spinal cord injury
  8. stuttering priapism
  9. trigeminal neuralgia

For the treatment of spasticity, muscle spasm (not due to rheumatic conditions), myoclonus, and muscle rigidity in multiple sclerosis and spinal cord injury or diseases

Side Effects

  1. abdominal pain
  2. agitation
  3. akathisia
  4. alopecia
  5. amnesia
  6. anemia
  7. anorexia
  8. anxiety
  9. apnea
  10. asthenia
  11. ataxia
  12. back pain
  13. blurred vision
  14. bradycardia
  15. bronchospasm
  16. chest pain (unspecified)
  17. chills
  18. coma
  19. confusion
  20. constipation
  21. depression
  22. diarrhea
  23. diplopia
  24. disseminated intravascular coagulation (DIC)
  25. dizziness
  26. drowsiness
  27. dysarthria
  28. dysgeusia
  29. dyskinesia
  30. dyspepsia
  31. dyspnea
  32. dystonic reaction
  33. dysuria
  34. ejaculation dysfunction
  35. emotional lability
  36. encephalopathy
  37. euphoria
  38. flatulence
  39. hallucinations
  40. headache
  41. hematuria
  42. hyperglycemia
  43. hyperhidrosis
  44. hypersalivation
  45. hypertension
  46. hypertonia
  47. hyperventilation
  48. hyporeflexia
  49. hypotension
  50. hypothermia
  51. hypotonia
  52. hypoventilation
  53. ileus
  54. impaired cognition
  55. impotence (erectile dysfunction)
  56. increased urinary frequency
  57. influenza
  58. insomnia
  59. leukocytosis
  60. libido decrease
  61. malaise
  62. malignant hyperthermia
  63. meningitis
  64. miosis
  65. musculoskeletal pain
  66. mydriasis
  67. nasal congestion
  68. nausea
  69. neuroleptic malignant syndrome
  70. nocturia
  71. nystagmus
  72. oliguria
  73. orgasm dysfunction
  74. orthostatic hypotension
  75. palpitations
  76. paranoia
  77. paresthesias
  78. peripheral edema
  79. petechiae
  80. premature atrial contractions (PACs)
  81. priapism
  82. pruritus
  83. psychological dependence
  84. psychosis
  85. pulmonary embolism
  86. QT prolongation
  87. rash
  88. renal failure (unspecified)
  89. respiratory depression
  90. rhabdomyolysis
  91. rhinitis
  92. seizures
  93. skin ulcer
  94. stroke
  95. suicidal ideation
  96. thrombosis
  97. tinnitus
  98. tremor
  99. urinary incontinence
  100. urinary retention
  101. urticaria
  102. vaginitis
  103. ventricular tachycardia
  104. vomiting
  105. weakness
  106. weight gain
  107. withdrawal
  108. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • anticoagulant therapy
  • bipolar disorder
  • breast-feeding
  • cerebral palsy
  • children
  • coadministration with other CNS depressants
  • coagulopathy
  • dental disease
  • depression
  • diabetes mellitus
  • dialysis
  • driving or operating machinery
  • epidural administration
  • ethanol ingestion
  • geriatric
  • head trauma
  • infants
  • infection
  • intracranial bleeding
  • intramuscular administration
  • intrathecal administration
  • intravenous administration
  • ovarian cyst
  • phenylketonuria
  • pregnancy
  • priapism
  • psychosis
  • renal failure
  • renal impairment
  • schizophrenia
  • seizure disorder
  • seizures
  • stroke
  • subcutaneous administration
  • thrombocytopenia

Interactions

  • Acebutolol
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Tramadol
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Alprazolam
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxapine
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Anxiolytics; Sedatives; and Hypnotics
  • Apomorphine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atracurium
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Bacitracin
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Beta-adrenergic blockers
  • Betaxolol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Botulinum Toxins
  • Brimonidine; Timolol
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Calcium-channel blockers
  • Cannabidiol
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carteolol
  • Carvedilol
  • Cenobamate
  • Central-acting adrenergic agents
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Cisatracurium
  • Clevidipine
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Deutetrabenazine
  • Dexmedetomidine
  • Dextromethorphan; Promethazine
  • Diazepam
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dorzolamide; Timolol
  • Doxacurium
  • Doxazosin
  • Dronabinol
  • Droperidol
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Entacapone
  • Eplerenone
  • Epoprostenol
  • Esketamine
  • Esmolol
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Etomidate
  • Felodipine
  • Fentanyl
  • Fluphenazine
  • Flurazepam
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fospropofol
  • Gabapentin
  • General anesthetics
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halothane
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Iloprost
  • Isoflurane
  • Isradipine
  • Ketamine
  • Labetalol
  • Lasmiditan
  • Levobetaxolol
  • Levobunolol
  • Levocetirizine
  • Levorphanol
  • Lisinopril
  • Lofexidine
  • Loop diuretics
  • Lorazepam
  • Loxapine
  • Lumateperone
  • Maprotiline
  • Mecamylamine
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Mesoridazine
  • Methadone
  • Methocarbamol
  • Methohexital
  • Methscopolamine
  • Metoprolol
  • Midazolam
  • Mirtazapine
  • Mivacurium
  • Moexipril
  • Molindone
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nadolol
  • Nalbuphine
  • Nebivolol
  • Nebivolol; Valsartan
  • Neuromuscular blockers
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Pancuronium
  • Penbutolol
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perindopril
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phenothiazines
  • Phenoxybenzamine
  • Phentolamine
  • Phenylephrine; Promethazine
  • Pindolol
  • Potassium-sparing diuretics
  • Prazosin
  • Pregabalin
  • Primidone
  • Prochlorperazine
  • Promethazine
  • Propofol
  • Propranolol
  • Quazepam
  • Quinapril
  • Ramipril
  • Rapacuronium
  • Remifentanil
  • Reserpine
  • Rocuronium
  • Secobarbital
  • Sedating H1-blockers
  • Sevoflurane
  • Sodium Oxybate
  • Spironolactone
  • Succinylcholine
  • Sufentanil
  • Tapentadol
  • Temazepam
  • Terazosin
  • Thalidomide
  • Thiazide diuretics
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Timolol
  • Tizanidine
  • Tolcapone
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Trazodone
  • Treprostinil
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Tubocurarine
  • Valerian, Valeriana officinalis
  • Vasodilators
  • Vecuronium
  • Verapamil
  • Zaleplon
  • Ziprasidone
  • Zolpidem

Sharing is caring!

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856