Baloxavir Marboxil

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Baloxavir Marboxil Brand Name– XOFLUZA

What is Baloxavir Marboxil

Baloxavir marboxil is an oral antiviral drug; it is given as a single weight-based dose to treat uncomplicated influenza infections in patients 12 years and older who have had symptoms for less than 48 hours and who are otherwise healthy or at high risk of developing influenza-related complications.

Baloxavir is active against both influenza A and B viruses. It is the first drug approved that targets the influenza virus-specific enzyme polymerase acidic (PA) protein, which is located within the viral RNA polymerase complex. By inhibiting the endonuclease activity of the PA protein, the drug prevents viral gene transcription and ultimately viral replication.

Baloxavir is not a substitute for an annual influenza virus vaccination. Instead, antiviral drugs are considered adjuncts to the prevention and control of influenza; annual influenza vaccination remains the main option for reducing the impact of influenza.

Indications

  1. influenza A virus
  2. influenza A virus infection
  3. influenza B virus
  4. influenza B virus infection

Side Effects

  1. anaphylactic shock
  2. anaphylactoid reactions
  3. angioedema
  4. colitis
  5. delirium
  6. diarrhea
  7. dysphonia
  8. erythema multiforme
  9. hallucinations
  10. headache
  11. melena
  12. nausea
  13. rash
  14. sinusitis
  15. urticaria
  16. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • infection
  • pregnancy
  • serious hypersensitivity reactions or anaphylaxis
  • vaccination
  • viral infection

Interactions

  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Calcium Acetate
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Gluconate
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Intranasal Influenza Vaccine
  • Iron Sucrose, Sucroferric Oxyhydroxide
  • Magnesium Citrate
  • Magnesium Hydroxide
  • Zinc
  • Zinc Salts

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