Baloxavir Marboxil Brand Name– XOFLUZA
What is Baloxavir Marboxil
Baloxavir marboxil is an oral antiviral drug; it is given as a single weight-based dose to treat uncomplicated influenza infections in patients 12 years and older who have had symptoms for less than 48 hours and who are otherwise healthy or at high risk of developing influenza-related complications.
Baloxavir is active against both influenza A and B viruses. It is the first drug approved that targets the influenza virus-specific enzyme polymerase acidic (PA) protein, which is located within the viral RNA polymerase complex. By inhibiting the endonuclease activity of the PA protein, the drug prevents viral gene transcription and ultimately viral replication.
Baloxavir is not a substitute for an annual influenza virus vaccination. Instead, antiviral drugs are considered adjuncts to the prevention and control of influenza; annual influenza vaccination remains the main option for reducing the impact of influenza.
Indications
- influenza A virus
- influenza A virus infection
- influenza B virus
- influenza B virus infection
Side Effects
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- colitis
- delirium
- diarrhea
- dysphonia
- erythema multiforme
- hallucinations
- headache
- melena
- nausea
- rash
- sinusitis
- urticaria
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- infection
- pregnancy
- serious hypersensitivity reactions or anaphylaxis
- vaccination
- viral infection
Interactions
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Gluconate
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Intranasal Influenza Vaccine
- Iron Sucrose, Sucroferric Oxyhydroxide
- Magnesium Citrate
- Magnesium Hydroxide
- Zinc
- Zinc Salts