Atropine Hyoscyamine Phenobarbital Scopolamine

Atropine Hyoscyamine Phenobarbital Scopolamine Brand Names

Alkabel-SR | Antispasmodic | Barbidonna | Donnaphen | Donnatal | Donnatal Extentabs | Haponal | Hypersed | Medi-Tal | PB-HYOS | Phenohytro | Quadraplex | RE-PB Hyos | SE-DONNA PB HYOS | Servira | Spacol

What is Atropine Hyoscyamine Phenobarbital Scopolamine

Atropine Hyoscyamine Phenobarbital Scopolamine are used together in an oral preparation to treat GI-related problems such as irritable bowel syndrome.

Atropine, hyoscyamine, and scopolamine are the active components of belladonna and are sometimes referred to as belladonna alkaloids or belladonna extract.

Atropine, hyoscyamine, and scopolamine are anticholinergic agents and are used in this combination product to decrease GI motility and for their antisecretory effects.

Phenobarbital is a barbiturate agent used for its sedative actions.

Historically, this combination was one of the first drugs used in the treatment of duodenal ulcer, however, more effective agents (e.g., H₂-blockers, Gastric acid-pump inhibitors) with less potential for adverse effects are available.

Conclusive evidence supporting whether anticholinergic/antispasmodic drugs aid in the healing of a duodenal ulcer, decrease the rate of ulcer recurrences, or prevent complications is not available.

Atropine Hyoscyamine Phenobarbital Scopolamine has been available since before 1938.

Indications

• duodenal ulcer
• enterocolitis
• irritable bowel syndrome

For the adjunctive treatment of irritable bowel syndrome† (irritable colon, spastic colon, mucous colitis), acute enterocolitis†, or duodenal ulcer

Side Effects

1. acneiform rash
2. angina
3. anxiety
4. ataxia
5. blurred vision
6. bradycardia
7. bullous rash
8. confusion
9. constipation
10. cycloplegia
11. delirium
12. depression
13. dizziness
14. dyspepsia
15. dysphagia
16. fever
17. flushing
18. hallucinations
19. headache
20. ileus
21. impotence (erectile dysfunction)
22. insomnia
23. interstitial nephritis
24. leukocytosis
25. libido decrease
26. maculopapular rash
27. megaloblastic anemia
28. miosis
29. mydriasis
30. nausea
31. nightmares
32. nystagmus
33. ocular hypertension
34. osteopenia
35. photophobia
36. photosensitivity
37. ptosis
38. purpura
39. pyrosis (heartburn)
40. sinus tachycardia
41. Stevens-Johnson syndrome
42. thrombocytopenia
43. urinary retention
44. urticaria
45. vomiting
46. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• achalasia
• acute myocardial infarction
• ambient temperature increase
• anticholinergic medications
• anticoagulant therapy
• asthma
• autonomic neuropathy
• barbiturate hypersensitivity
• bladder obstruction
• bleeding
• breast-feeding
• carbamazepine hypersensitivity
• cardiac arrhythmias
• cardiac disease
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• colostomy
• contact lenses
• coronary artery disease
• dehydration
• dental disease
• depression
• diarrhea
• driving or operating machinery
• esophagitis
• ethanol ingestion
• fever
• gastroesophageal reflux disease (GERD)
• geriatric
• GI obstruction
• glaucoma
• heart failure
• hepatic disease
• hiatal hernia
• hydantoin hypersensitivity
• hypertension
• hyperthyroidism
• ileostomy
• ileus
• infants
• lactase deficiency
• mental status changes
• mitral stenosis
• myasthenia gravis
• neonates
• peptic ulcer disease
• porphyria
• pregnancy
• prostatic hypertrophy
• pseudomembranous colitis
• pulmonary disease
• pyloric stenosis
• renal failure
• renal impairment
• respiratory depression
• respiratory infection
• strenuous exercise
• substance abuse
• suicidal ideation
• synechia
• tachycardia
• thyrotoxicosis
• toxic megacolon
• ulcerative colitis
• urinary retention
• urinary tract obstruction

Interactions

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• Ramelteon
• Ranolazine
• Rasagiline
• Red Yeast Rice
• Regorafenib
• Remdesivir
• Remifentanil
• Repaglinide
• Reserpine
• Revefenacin
• Ribociclib
• Ribociclib; Letrozole
• Rifampin
• Rifapentine
• Rilpivirine
• Riluzole
• Rimegepant
• Riociguat
• Ripretinib
• Risperidone
• Ritodrine
• Ritonavir
• Rivaroxaban
• Rivastigmine
• Roflumilast
• Rolapitant
• Romidepsin
• Ropinirole
• Ropivacaine
• Rotigotine
• Rucaparib
• Rufinamide
• Ruxolitinib
• Safinamide
• Salicylates
• Salsalate
• Sapropterin
• Saquinavir
• Scopolamine
• Secretin
• Sedating H1-blockers
• Segesterone Acetate; Ethinyl Estradiol
• Selegiline
• Selpercatinib
• Selumetinib
• Sertraline
• Sildenafil
• Simeprevir
• Simvastatin
• Simvastatin; Sitagliptin
• Sincalide
• Siponimod
• Sirolimus
• Skeletal Muscle Relaxants
• Sodium Bicarbonate
• Sodium Oxybate
• Sofosbuvir
• Sofosbuvir; Velpatasvir
• Sofosbuvir; Velpatasvir; Voxilaprevir
• Solifenacin
• Sonidegib
• Sorafenib
• Spironolactone
• Sufentanil
• Sunitinib
• Suvorexant
• Tacrine
• Tacrolimus
• Tadalafil
• Tamoxifen
• Tapentadol
• Tasimelteon
• Tazemetostat
• Tegaserod
• Telaprevir
• Telithromycin
• Telotristat Ethyl
• Temazepam
• Temsirolimus
• Teniposide
• Tenofovir Alafenamide
• Tenofovir Alafenamide
• Terbinafine
• Tetrabenazine
• Tetracaine
• Tezacaftor; Ivacaftor
• Thalidomide
• Theophylline, Aminophylline
• Thiazide diuretics
• Thioridazine
• Thiotepa
• Thiothixene
• Thyroid hormones
• Tiagabine
• Ticagrelor
• Tinidazole
• Tiotropium
• Tiotropium; Olodaterol
• Tipranavir
• Tizanidine
• Tofacitinib
• Tolcapone
• Tolterodine
• Tolvaptan
• Topiramate
• Toremifene
• Trabectedin
• Tramadol
• Trandolapril; Verapamil
• Tranylcypromine
• Trazodone
• Tretinoin, ATRA
• Triamcinolone
• Triazolam
• Tricyclic antidepressants
• Trifluoperazine
• Trimethobenzamide
• Trimetrexate
• Triprolidine
• Trospium
• Tucatinib
• Ubrogepant
• Ulipristal
• Umeclidinium
• Umeclidinium; Vilanterol
• Upadacitinib
• Valbenazine
• Valerian, Valeriana officinalis
• Valproic Acid, Divalproex Sodium
• Vandetanib
• Vemurafenib
• Venetoclax
• Verapamil
• Vigabatrin
• Vilazodone
• Vincristine
• Vincristine Liposomal
• Vorapaxar
• Voriconazole
• Vortioxetine
• Voxelotor
• Warfarin
• Zaleplon
• Zanubrutinib
• Ziconotide
• Ziprasidone
• Zolpidem
• Zonisamide