Atropine Difenoxin Brand Name– Motofen
What is Atropine Difenoxin
Atropine difenoxin (Motofen) is an orally administered antidiarrheal agent.
It contains difenoxin hydrochloride, a synthetic opiate agonist that is the principal active metabolite of diphenoxylate; it has a chemical structure similar to that of meperidine.
The product formulation contains small quantities of atropine to discourage deliberate abuse or overdosage of difenoxin.
Motofen is indicated as adjunctive therapy in the management of acute nonspecific diarrhea and acute exacerbations of chronic functional diarrhea.
Motofen was approved by the FDA in July 1978.
Indications
- diarrhea
For adjunctive treatment in the management of acute nonspecific diarrhea and acute exacerbations of chronic functional diarrhea
Side Effects
- anaphylactoid reactions
- angioedema
- anorexia
- blurred vision
- confusion
- constipation
- depression
- dizziness
- drowsiness
- euphoria
- fatigue
- flushing
- headache
- hyperthermia
- ileus
- insomnia
- nausea
- ocular pruritus
- pancreatitis
- pruritus
- respiratory depression
- sinus tachycardia
- toxic megacolon
- urinary retention
- urticaria
- vomiting
- xerosis
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- anticholinergic medications
- breast-feeding
- children
- dehydration
- Down’s syndrome
- driving or operating machinery
- electrolyte imbalance
- gastroenteritis
- geriatric
- hepatic disease
- infants
- infection
- jaundice
- MAOI therapy
- neonates
- potential for overdose or poisoning
- pregnancy
- pseudomembranous colitis
- substance abuse
- ulcerative colitis
Interactions
- Abatacept
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Aclidinium
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albuterol; Ipratropium
- Aldesleukin, IL-2
- Alfentanil
- Alosetron
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amantadine
- Ambenonium Chloride
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amobarbital
- Amoxapine
- Antacids
- Anxiolytics; Sedatives; and Hypnotics
- Apraclonidine
- Aripiprazole
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Oxycodone
- Atomoxetine
- Atracurium
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzonatate
- Bethanechol
- Bisacodyl
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Botulinum Toxins
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Phosphate, Supersaturated
- Cannabidiol
- Capsaicin; Metaxalone
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carisoprodol
- Castor Oil
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloral Hydrate
- Chlorcyclizine
- Chlordiazepoxide; Clidinium
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Cholinergic agonists
- Cisapride
- Cisatracurium
- Citalopram
- Citric Acid; Potassium Citrate
- Citric Acid; Potassium Citrate; Sodium Citrate
- Clemastine
- Clobazam
- Clomipramine
- Clonidine
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colesevelam
- COMT inhibitors
- Crofelemer
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dantrolene
- Darifenacin
- Desipramine
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Docusate Sodium; Senna
- Donepezil
- Donepezil; Memantine
- Doxacurium
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Edrophonium
- Eluxadoline
- Entacapone
- Ephedrine
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Eszopiclone
- Ethanol
- Ethotoin
- Etomidate
- Ezogabine
- Fentanyl
- Fesoterodine
- Fexofenadine; Pseudoephedrine
- Flavoxate
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Umeclidinium; Vilanterol
- food
- Fosphenytoin
- Gabapentin
- Galantamine
- Glucagon
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Glycopyrronium
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Potassium Guaiacolsulfonate
- Guaifenesin; Pseudoephedrine
- Guanabenz
- Guanfacine
- Haloperidol
- Hetastarch; Dextrose; Electrolytes
- Homatropine; Hydrocodone
- Hydantoins
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Imipramine
- Indacaterol; Glycopyrrolate
- Iodine; Potassium Iodide, KI
- Ipratropium
- Itraconazole
- Ketamine
- Lactulose
- Lasmiditan
- Laxatives
- Lemborexant
- Levocetirizine
- Levodopa
- Levorphanol
- Linaclotide
- Linezolid
- Lofexidine
- Loperamide
- Loperamide; Simethicone
- Loratadine; Pseudoephedrine
- Loxapine
- Lubiprostone
- Lumateperone
- Lurasidone
- Macimorelin
- Magnesium Citrate
- Magnesium Hydroxide
- Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
- Maprotiline
- Meclizine
- Memantine
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Metaxalone
- Methacholine
- Methadone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methocarbamol
- Methohexital
- Methscopolamine
- Methylcellulose
- Methyldopa
- Metoclopramide
- Metyrapone
- Metyrosine
- Mineral Oil
- Minocycline
- Mirtazapine
- Mitotane
- Mivacurium
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Naloxone
- Naltrexone
- Naproxen; Pseudoephedrine
- Neostigmine
- Neuromuscular blockers
- Nitrofurantoin
- Norepinephrine
- Nortriptyline
- Octreotide
- Olanzapine
- Omeprazole; Sodium Bicarbonate
- Opiate Agonists
- Orphenadrine
- Oxycodone
- Oxymorphone
- Pancuronium
- Papaverine
- Paroxetine
- Pegvisomant
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenothiazines
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Physostigmine
- Pimozide
- Polyethylene Glycol
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Polyethylene Glycol; Electrolytes; Bisacodyl
- Potassium
- Potassium Acetate
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Potassium Gluconate
- Potassium Iodide, KI
- Pramipexole
- Pramlintide
- Pregabalin
- Primidone
- Procainamide
- Procarbazine
- Prochlorperazine
- Promethazine
- Propoxyphene
- Proton pump inhibitors
- Protriptyline
- Pseudoephedrine
- Psyllium
- Pyridostigmine
- Quetiapine
- Quinidine
- Rapacuronium
- Rasagiline
- Remifentanil
- Revefenacin
- Risperidone
- Ritodrine
- Rivastigmine
- Rocuronium
- Secobarbital
- Secretin
- Sedating H1-blockers
- Senna
- Sildenafil
- Sincalide
- Sodium Bicarbonate
- Sodium Oxybate
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Solifenacin
- Sorbitol
- Succinylcholine
- Sufentanil
- Tacrine
- Tapentadol
- Tegaserod
- Tetrabenazine
- Thiazide diuretics
- Thiopental
- Thioridazine
- Thiothixene
- Tiotropium
- Tiotropium; Olodaterol
- Tolcapone
- Tolterodine
- Topiramate
- Tramadol
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimethobenzamide
- Trimipramine
- Triprolidine
- Trospium
- Tubocurarine
- Umeclidinium
- Umeclidinium; Vilanterol
- Vecuronium
- Zaleplon
- Ziprasidone
- Zolpidem
- Zonisamide
