Atenolol Chlorthalidone

Atenolol Chlorthalidone Brand Name– Tenoretic

What is Atenolol Chlorthalidone

Atenolol chlorthalidone are used together in an oral preparation to treat hypertension.

These drugs have different mechanisms of action and have additive hypotensive activity.

Atenolol is a beta1-specific, hydrophilic beta-blocker, with a long plasma half-life allowing for once-daily dosing. Due to its low-lipid solubility, atenolol is renally eliminated, minimally metabolized, and has a lower potential for inducing CNS side effects compared to lipid-soluble beta-blockers (e.g., propranolol).

Atenolol does not possess significant membrane-stabilizing activity (MSA) or intrinsic sympathomimetic properties (ISA). Chlorthalidone is a thiazide-like diuretic, with a prolonged duration of action.

Compared to other thiazides, chlorthalidone has the longest duration of action, but the diuretic effect is similar to other thiazides at maximal recommended therapeutic doses.

Tenoretic® was approved by the FDA on June 8, 1984.

Indications

  • hypertension

For the treatment of hypertension in patients who do not respond to monotherapy

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. alopecia
  4. aplastic anemia
  5. AV block
  6. azotemia
  7. blurred vision
  8. bradycardia
  9. bronchospasm
  10. depression
  11. diabetes mellitus
  12. diaphoresis
  13. diarrhea
  14. dizziness
  15. drowsiness
  16. dyspnea
  17. elevated hepatic enzymes
  18. erythema
  19. erythema multiforme
  20. exfoliative dermatitis
  21. fatigue
  22. fever
  23. glycosuria
  24. gout
  25. hallucinations
  26. headache
  27. heart failure
  28. hemolytic anemia
  29. hyperbilirubinemia
  30. hypercalcemia
  31. hypercholesterolemia
  32. hyperglycemia
  33. hypertension
  34. hypertriglyceridemia
  35. hyperuricemia
  36. hypochloremia
  37. hypoglycemia
  38. hypokalemia
  39. hypomagnesemia
  40. hypotension
  41. hypovolemia
  42. impotence (erectile dysfunction)
  43. interstitial nephritis
  44. jaundice
  45. lethargy
  46. leukopenia
  47. metabolic alkalosis
  48. muscle cramps
  49. nausea
  50. nephrolithiasis
  51. nightmares
  52. orthostatic hypotension
  53. palpitations
  54. pancreatitis
  55. pancytopenia
  56. periarteritis
  57. photosensitivity
  58. pruritus
  59. psoriaform rash
  60. psoriasis
  61. psychosis
  62. purpura
  63. rash
  64. renal failure (unspecified)
  65. sialadenitis
  66. sinus tachycardia
  67. Stevens-Johnson syndrome
  68. syncope
  69. teratogenesis
  70. thrombocytopenia
  71. toxic epidermal necrolysis
  72. tremor
  73. urticaria
  74. vertigo
  75. visual impairment
  76. vomiting
  77. wheezing
  78. withdrawal
  79. xanthopsia
  80. xerophthalmia
  81. xerostomia

Monitoring Parameters

  • blood glucose
  • blood pressure
  • heart rate
  • serum creatinine/BUN
  • serum electrolytes
  • serum uric acid

Contraindications

  • abrupt discontinuation
  • acute bronchospasm
  • anuria
  • asthma
  • AV block
  • beta-blocker hypersensitivity
  • bradycardia
  • breast-feeding
  • bronchitis
  • cardiogenic shock
  • cerebrovascular disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • depression
  • diabetes mellitus
  • driving or operating machinery
  • electrolyte imbalance
  • emphysema
  • geriatric
  • gout
  • heart failure
  • hepatic disease
  • hypercalcemia
  • hypercholesterolemia
  • hyperglycemia
  • hyperthyroidism
  • hypertriglyceridemia
  • hyperuricemia
  • hypochloremia
  • hypokalemia
  • hypomagnesemia
  • hyponatremia
  • hypotension
  • hypovolemia
  • labor
  • metabolic alkalosis
  • myasthenia gravis
  • obstetric delivery
  • orthostatic hypotension
  • pancreatitis
  • peripheral vascular disease
  • pheochromocytoma
  • pregnancy
  • psoriasis
  • pulmonary disease
  • pulmonary edema
  • Raynaud’s phenomenon
  • renal disease
  • renal failure
  • renal impairment
  • sick sinus syndrome
  • sulfonamide hypersensitivity
  • sunlight (UV) exposure
  • surgery
  • sympathectomy
  • syncope
  • systemic lupus erythematosus (SLE)
  • thiazide diuretic hypersensitivity
  • thyroid disease
  • thyrotoxicosis
  • vasospastic angina
  • ventricular dysfunction

Interactions

  • Acarbose
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acetazolamide
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  • Amlodipine; Olmesartan
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  • Amlodipine; Valsartan
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  • Cardiac glycosides
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  • Cevimeline
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  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
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  • Chlorpheniramine; Pseudoephedrine
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  • Desflurane
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  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Quinidine
  • Diazoxide
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  • Diclofenac
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  • Enalapril, Enalaprilat
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  • Encainide
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  • Fluvoxamine
  • food
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  • Fosinopril
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  • Fospropofol
  • Galantamine
  • Gallium Ga 68 Dotatate
  • General anesthetics
  • Ginger, Zingiber officinale
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  • Glucagon
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  • Glycopyrrolate
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  • Granisetron
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  • Hydrocodone
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  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hyoscyamine
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  • Ibuprofen
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  • Solifenacin
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  • Vitamin D
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  • Warfarin
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  • Ziconotide
  • Ziprasidone
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