Artemether Lumefantrine Brand Name– Coartem
What is Artemether Lumefantrine
Artemether lumefantrine is a fixed artemisinin-based combination tablet indicated for the treatment of acute, uncomplicated malaria infections in patients 2 months and older with a bodyweight of at least 5 kg.
Both components are blood schizonticides with complementary pharmacokinetics and dissimilar modes of action providing synergistic antimalarial activity, while preventing the development of resistance.
Artemether lumefantrine is effective against both drug-sensitive and drug-resistant Plasmodium falciparum.
Artemisinin-based therapies are potent with rapid onset of anti-parasitic activity and are primarily recommended by the World Health Organization (WHO).
These regimens are active against all Plasmodium species that infect humans.
When artemisinin-based therapies are combined with longer-acting antimalarial agents, such as lumefantrine, shorter courses of therapy are an option.
Indications
- malaria
- Plasmodium falciparum
- Plasmodium vivax
Side Effects
- abdominal pain
- agitation
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- arthralgia
- asthenia
- ataxia
- back pain
- bullous rash
- chills
- conjunctivitis
- constipation
- cough
- diarrhea
- dizziness
- dyspepsia
- dysphagia
- elevated hepatic enzymes
- eosinophilia
- fatigue
- fever
- headache
- hematuria
- hemolytic anemia
- hepatomegaly
- hyperreflexia
- hypoesthesia
- hypokalemia
- infection
- influenza
- insomnia
- leukocytosis
- leukopenia
- malaise
- myalgia
- nausea
- nystagmus
- palpitations
- peptic ulcer
- pharyngitis
- proteinuria
- pruritus
- QT prolongation
- rash
- rhinitis
- splenomegaly
- thrombocytopenia
- thrombocytosis
- tinnitus
- tremor
- urticaria
- vertigo
- vomiting
Monitoring Parameters
- CBC with differential
- ECG
Contraindications
- alcoholism
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- contraception requirements
- coronary artery disease
- diabetes mellitus
- females
- geriatric
- heart failure
- hepatic disease
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- infants
- long QT syndrome
- malnutrition
- myocardial infarction
- neonates
- pregnancy
- QT prolongation
- renal failure
- renal impairment
- thyroid disease
- torsade de pointes
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Aldesleukin, IL-2
- Alfuzosin
- Amiodarone
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
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- Apomorphine
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- Armodafinil
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- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
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- Atazanavir; Cobicistat
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- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carvedilol
- Ceritinib
- Cevimeline
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- Chloroquine
- Chlorpheniramine
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- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
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- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
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- grapefruit juice
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- Guaifenesin; Hydrocodone; Pseudoephedrine
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- Hydrochlorothiazide, HCTZ; Metoprolol
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