Aprepitant Fosaprepitant

Aprepitant Fosaprepitant Brand Names- CINVANTI / Emend

What is Aprepitant Fosaprepitant

Aprepitant fosaprepitant an antiemetic, is a highly selective substance P neurokinin 1 (NK1) receptor antagonist.

Aprepitant is available in oral and intravenous formulations; fosaprepitant, the prodrug of aprepitant, is only available as an intravenous formulation.

Aprepitant (oral and IV) and injectable fosaprepitant are approved for use in combination with standard antiemetic regimens (5HT3 antagonist plus a corticosteroid) to prevent acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated with highly emetogenic regimens and delayed CINV associated with moderately emetogenic regimens.

While previously FDA-approved for post-operative nausea and vomiting, the manufacturers removed this indication from the labels in September 2019.

Indications

  • chemotherapy-induced nausea/vomiting prophylaxis

For chemotherapy-induced nausea/vomiting prophylaxis (CINV prophylaxis)

for acute and delayed chemotherapy-induced nausea/vomiting (CINV) prophylaxis associated with highly-emetogenic chemotherapy\

Side Effects

  1. abdominal pain
  2. abnormal dreams
  3. acne vulgaris
  4. agitation
  5. alopecia
  6. anaphylactic shock
  7. anaphylactoid reactions
  8. anemia
  9. angioedema
  10. anxiety
  11. asthenia
  12. bradycardia
  13. candidiasis
  14. chills
  15. colitis
  16. conjunctivitis
  17. constipation
  18. cough
  19. dehydration
  20. diarrhea
  21. dizziness
  22. dysgeusia
  23. dyspepsia
  24. dyspnea
  25. dysuria
  26. edema
  27. elevated hepatic enzymes
  28. eructation
  29. erythema
  30. euphoria
  31. fatigue
  32. flatulence
  33. flushing
  34. gastritis
  35. gastroesophageal reflux
  36. headache
  37. hematuria
  38. hiccups
  39. hot flashes
  40. hyperglycemia
  41. hyperhidrosis
  42. hypokalemia
  43. hyponatremia
  44. hypotension
  45. ileus
  46. infection
  47. infusion-related reactions
  48. injection site reaction
  49. lethargy
  50. leukopenia
  51. malaise
  52. muscle cramps
  53. musculoskeletal pain
  54. myalgia
  55. nausea
  56. neurotoxicity
  57. neutropenia
  58. palpitations
  59. peripheral edema
  60. peripheral neuropathy
  61. pharyngitis
  62. phlebitis
  63. photosensitivity
  64. polydipsia
  65. polyuria
  66. proteinuria
  67. pruritus
  68. rash
  69. skin irritation
  70. skin necrosis
  71. sneezing
  72. Stevens-Johnson syndrome
  73. stomatitis
  74. syncope
  75. throat irritation
  76. thrombocytopenia
  77. tinnitus
  78. toxic epidermal necrolysis
  79. urticaria
  80. vasculitis
  81. vomiting
  82. weight gain
  83. weight loss
  84. wheezing
  85. xerostomia

Monitoring Parameters

  • heart rate
  • LFTs

Contraindications

  • anticoagulant therapy
  • breast-feeding
  • contraception requirements
  • contraceptive devices
  • geriatric
  • hepatic disease
  • hypotension
  • infusion-related reactions
  • pregnancy

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Abemaciclib
  • Acalabrutinib
  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Alfentanil
  • Alfuzosin
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Almotriptan
  • Alprazolam
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amprenavir
  • Apalutamide
  • Aripiprazole
  • Armodafinil
  • Artemether; Lumefantrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Avanafil
  • Avapritinib
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Bedaquiline
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  • Benzhydrocodone; Acetaminophen
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  • Bromocriptine
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  • Budesonide
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  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butabarbital
  • Caffeine; Ergotamine
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cannabidiol
  • Carbamazepine
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  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Cariprazine
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  • Cevimeline
  • Chloramphenicol
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpropamide
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  • Ciprofloxacin
  • Cisapride
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  • Cobimetinib
  • Cocaine
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  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine
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  • Conivaptan
  • Conjugated Estrogens
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  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deferasirox
  • Deflazacort
  • Delavirdine
  • Dexamethasone
  • Dexlansoprazole
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diclofenac
  • Diclofenac; Misoprostol
  • Dienogest; Estradiol valerate
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Disopyramide
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  • Drospirenone; Estradiol
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  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Dutasteride; Tamsulosin
  • Duvelisib
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Eletriptan
  • Elexacaftor; tezacaftor; ivacaftor
  • Eliglustat
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enalapril; Felodipine
  • Encorafenib
  • Entrectinib
  • Enzalutamide
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  • Ergoloid Mesylates
  • Ergonovine
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  • Erythromycin; Sulfisoxazole
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  • Estropipate
  • Eszopiclone
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  • Ethinyl Estradiol; Desogestrel
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  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethosuximide
  • Ethotoin
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  • Etravirine
  • Everolimus
  • Ezetimibe; Simvastatin
  • Famotidine; Ibuprofen
  • Fedratinib
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  • Fentanyl
  • Flibanserin
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  • Fluoxetine; Olanzapine
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  • food
  • Fosamprenavir
  • Fosphenytoin
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Granisetron
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guanfacine
  • Halofantrine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydroxyprogesterone
  • Ibrutinib
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  • Ketoconazole
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  • Lidocaine
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  • Lomitapide
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  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Losartan
  • Lovastatin
  • Lovastatin; Niacin
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Lurasidone
  • Macitentan
  • Maprotiline
  • Maraviroc
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  • Mefloquine
  • Meloxicam
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  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Methadone
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  • Mifepristone
  • Mitotane
  • Modafinil
  • Nafcillin
  • Naldemedine
  • Naloxegol
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nebivolol; Valsartan
  • Nefazodone
  • Nelfinavir
  • Neratinib
  • Netupitant, Fosnetupitant; Palonosetron
  • Nevirapine
  • Niacin; Simvastatin
  • Nicardipine
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  • Norgestrel
  • Nortriptyline
  • Octreotide
  • Olaparib
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole
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  • Omeprazole; Sodium Bicarbonate
  • Ondansetron
  • Oritavancin
  • Oxybutynin
  • Oxycodone
  • Paclitaxel
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  • Panobinostat
  • Paricalcitol
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  • Pentobarbital
  • Perampanel
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  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenytoin
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  • Progesterone
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  • Quinine
  • Rabeprazole
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  • Ranolazine
  • Repaglinide
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
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  • Rifapentine
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  • Rivaroxaban
  • Roflumilast
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  • Solifenacin
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  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Suvorexant
  • Tacrolimus
  • Tadalafil
  • Tamsulosin
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  • Telaprevir
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  • Telotristat Ethyl
  • Teniposide
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  • Tezacaftor; Ivacaftor
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  • Tiagabine
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  • Tolterodine
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  • Torsemide
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  • Trimipramine
  • Ubrogepant
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  • Valproic Acid, Divalproex Sodium
  • Valsartan
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  • Vorapaxar
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  • Warfarin
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  • Zafirlukast
  • Zanubrutinib
  • Zileuton
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
  • Zonisamide
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