Apalutamide Brand Name– ERLEADA
What is Apalutamide
Apalutamide is an androgen receptor inhibitor approved for the treatment of patients with nonmetastatic castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer.
Patients treated with apalutamide experienced more falls and fractures in clinical trials than patients who received placebo; patients should be evaluated for risk and treated with bone-targeting agents as appropriate.
Coadministration of certain drugs may need to be avoided or dosage adjustments may be necessary; review drug interactions prior to administration.
Indications
- prostate cancer
For the treatment of prostate cancer
for the treatment of nonmetastatic castration-resistant prostate cancer
Side Effects
- anemia
- anorexia
- arthralgia
- asthenia
- bone fractures
- cardiac arrest
- conjunctivitis
- diarrhea
- dysgeusia
- edema
- erythema multiforme
- exfoliative dermatitis
- fatigue
- GI perforation
- heart failure
- hematuria
- hot flashes
- hypercholesterolemia
- hyperglycemia
- hyperkalemia
- hypertension
- hypertriglyceridemia
- hypothyroidism
- infection
- intracranial bleeding
- leukopenia
- lymphopenia
- maculopapular rash
- muscle cramps
- myocardial infarction
- nausea
- nephrotoxicity
- oral ulceration
- penile edema
- peripheral edema
- pruritus
- QT prolongation
- rash
- respiratory arrest
- seizures
- skin erosion
- stomatitis
- stroke
- urticaria
- vesicular rash
- weight loss
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- angina
- bone fractures
- breast-feeding
- contraception requirements
- coronary artery disease
- diabetes mellitus
- driving or operating machinery
- geriatric
- heart failure
- hyperlipidemia
- hypertension
- infertility
- male-mediated teratogenicity
- myocardial infarction
- pregnancy
- reproductive risk
- seizure disorder
- seizures
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Abiraterone
- Acalabrutinib
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Afatinib
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alpelisib
- Alprazolam
- Amiodarone
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apixaban
- Apremilast
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Avanafil
- Avapritinib
- Axitinib
- Bedaquiline
- Benzhydrocodone; Acetaminophen
- Betrixaban
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bortezomib
- Bosutinib
- Brentuximab vedotin
- Brexpiprazole
- Brigatinib
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Cabozantinib
- Canagliflozin
- Canagliflozin; Metformin
- Cannabidiol
- Capmatinib
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Carvedilol
- Celecoxib
- Ceritinib
- Cevimeline
- Chloramphenicol
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cisapride
- Citalopram
- Clarithromycin
- Clindamycin
- Clonazepam
- Clopidogrel
- Clorazepate
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Conjugated Estrogens; Medroxyprogesterone
- Copanlisib
- Crizotinib
- Cyclosporine
- Dabigatran
- Daclatasvir
- Dapagliflozin; Saxagliptin
- Dapsone
- Darifenacin
- Darolutamide
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deferasirox
- Deflazacort
- Delavirdine
- Dexamethasone
- Dexlansoprazole
- Dextromethorphan; Quinidine
- Diazepam
- Diclofenac
- Diclofenac; Misoprostol
- Dienogest; Estradiol valerate
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Docetaxel
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doravirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxorubicin
- Dronabinol
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duvelisib
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Encorafenib
- Entrectinib
- Eravacycline
- Erdafitinib
- Erlotinib
- Esomeprazole
- Esomeprazole; Naproxen
- Estazolam
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Eszopiclone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etonogestrel
- Etravirine
- Everolimus
- Exemestane
- Fedratinib
- Felodipine
- Fentanyl
- Flibanserin
- Flurazepam
- Fosamprenavir
- Fostamatinib
- Gefitinib
- Gemfibrozil
- Gilteritinib
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glyburide
- Glyburide; Metformin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxyprogesterone
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Ifosfamide
- Imatinib
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indinavir
- Irinotecan
- Irinotecan Liposomal
- Isavuconazonium
- Isradipine
- Istradefylline
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ixazomib
- Ketoconazole
- Lamotrigine
- Lansoprazole
- Lansoprazole; Naproxen
- Lapatinib
- Larotrectinib
- Ledipasvir; Sofosbuvir
- Lefamulin
- Lemborexant
- Letermovir
- Leuprolide; Norethindrone
- Levonorgestrel
- Lidocaine
- Lidocaine; Prilocaine
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Lurbinectedin
- Macimorelin
- Macitentan
- Maraviroc
- Medroxyprogesterone
- Mefloquine
- Mestranol; Norethindrone
- Metformin; Repaglinide
- Metformin; Saxagliptin
- Methadone
- Midazolam
- Midostaurin
- Mifepristone
- Mirtazapine
- Modafinil
- Naldemedine
- Naloxegol
- Nanoparticle Albumin-Bound Paclitaxel
- Nateglinide
- Nefazodone
- Nelfinavir
- Neratinib
- Nevirapine
- Nifedipine
- Nilotinib
- Nimodipine
- Nintedanib
- Nisoldipine
- Norethindrone
- Norgestrel
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Osilodrostat
- Osimertinib
- Ospemifene
- Oxycodone
- Paclitaxel
- Palbociclib
- Paliperidone
- Panobinostat
- Pazopanib
- Pemigatinib
- Perampanel
- Perindopril; Amlodipine
- Pexidartinib
- Pimavanserin
- Pitolisant
- Polatuzumab Vedotin
- Ponatinib
- Posaconazole
- Praziquantel
- Progesterone
- Progestins
- Propranolol
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Regorafenib
- Repaglinide
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rilpivirine
- Rimegepant
- Riociguat
- Ripretinib
- Risperidone
- Ritonavir
- Rivaroxaban
- Roflumilast
- Rolapitant
- Romidepsin
- Ruxolitinib
- Saquinavir
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Selpercatinib
- Selumetinib
- Sildenafil
- Simeprevir
- Siponimod
- Sirolimus
- Sofosbuvir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Solifenacin
- Sonidegib
- Sorafenib
- Sufentanil
- Sunitinib
- Suvorexant
- Tacrolimus
- Tamoxifen
- Tasimelteon
- Tazemetostat
- Telithromycin
- Temsirolimus
- Teniposide
- Terbinafine
- Tezacaftor; Ivacaftor
- Thiotepa
- Tiagabine
- Ticagrelor
- Tinidazole
- Tipranavir
- Tofacitinib
- Tolvaptan
- Toremifene
- Torsemide
- Trabectedin
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Triazolam
- Tucatinib
- Ubrogepant
- Ulipristal
- Upadacitinib
- Valbenazine
- Valproic Acid, Divalproex Sodium
- Vandetanib
- Vemurafenib
- Venetoclax
- Verapamil
- Vilazodone
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Vortioxetine
- Voxelotor
- Warfarin
- Zaleplon
- Zanubrutinib
- Ziprasidone
- Zolpidem
- Zonisamide
