Antithrombin III

Antithrombin III Brand Names

ATryn | Thrombate III

What is Antithrombin III

Antithrombin III or Antithrombin (AT III), is another name for heparin cofactor I, a factor in plasma necessary for heparin to exert its anticoagulant activity. AT III is a natural anticoagulant synthesized in the liver.

It plays a major role in the regulation of hemostasis by inhibiting thrombin; factors IXa, Xa, XIa, and XIIa; kallikrein; and plasmin.

AT III deficiency predisposes patients to venous thromboembolic events by impairing the clearance of activated coagulation factors.

Thrombate III is AT III concentrate produced from pooled human plasma and indicated in patients with hereditary antithrombin III deficiency for treatment and prevention of thromboembolism, including peri-operative and peri-partum thromboembolism.

Another product, ATryn, is the first biological agent produced by genetically engineered animals (goats) and the first recombinant human antithrombin.

ATryn is produced utilizing recombinant DNA technology in which the DNA coding sequence for human antithrombin has been introduced along with a mammary gland-specific DNA sequence that directs the expression of antithrombin into the milk of goats.

ATryn is indicated for the prevention of peri-operative and peri-partum thromboembolic events in hereditary antithrombin deficient patients.

Indications

  1. deep venous thrombosis (DVT)
  2. deep venous thrombosis (DVT) prophylaxis
  3. disseminated intravascular coagulation (DIC)
  4. pulmonary embolism
  5. pulmonary embolism prophylaxis

For the treatment of deep venous thrombosis (DVT) or pulmonary embolism (PE) in patients with a deficiency in antithrombin III

Side Effects

  1. bleeding
  2. blurred vision
  3. chest pain (unspecified)
  4. chills
  5. dizziness
  6. dysgeusia
  7. dyspnea
  8. elevated hepatic enzymes
  9. fever
  10. flushing
  11. GI bleeding
  12. hematoma
  13. hematuria
  14. hepatitis
  15. infection
  16. injection site reaction
  17. nausea
  18. pruritus
  19. urticaria

Monitoring Parameters

  • antithrombin III levels

Contraindications

  • breast-feeding
  • goat milk protein hypersensitivity
  • labor
  • obstetric delivery
  • pregnancy
  • viral infection

Interactions

  • Abciximab
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Ado-Trastuzumab emtansine
  • Alteplase
  • Altretamine
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amlodipine; Celecoxib
  • Anagrelide
  • Antithymocyte Globulin
  • Apixaban
  • Ardeparin
  • Argatroban
  • Arsenic Trioxide
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Betrixaban
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bivalirudin
  • Caplacizumab
  • Carbenicillin
  • Celecoxib
  • Chlorambucil
  • Choline Salicylate; Magnesium Salicylate
  • Cilostazol
  • Clofarabine
  • Clopidogrel
  • Collagenase
  • Cytarabine, ARA-C
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Danazol
  • Dasatinib
  • Decitabine
  • Deferasirox
  • Defibrotide
  • Denileukin Diftitox
  • Desirudin
  • Dextran
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diflunisal
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Dipyridamole
  • Drotrecogin Alfa
  • Edoxaban
  • Eltrombopag
  • Enoxaparin
  • Epoprostenol
  • Eptifibatide
  • Esomeprazole; Naproxen
  • Esterified Estrogens; Methyltestosterone
  • Estramustine
  • Etodolac
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Floxuridine
  • Fluorouracil, 5-FU
  • Flurbiprofen
  • Folate analogs
  • Fondaparinux
  • Garlic, Allium sativum
  • Ginger, Zingiber officinale
  • Ginkgo, Ginkgo biloba
  • Green Tea
  • Hemin
  • Heparin
  • Hydrocodone; Ibuprofen
  • Hydroxyurea
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
  • Ibrutinib
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Icosapent ethyl
  • Iloprost
  • Imatinib
  • Indomethacin
  • Inotersen
  • Interferon Alfa-2a
  • Interferon Alfa-2b
  • Interferon Alfa-2b; Ribavirin
  • Interferon Alfa-n3
  • Interferon Alfacon-1
  • Intravenous Lipid Emulsions
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Lepirudin
  • Lomustine, CCNU
  • Low Molecular Weight Heparins
  • Magnesium Salicylate
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Methoxsalen
  • Methylsulfonylmethane, MSM
  • Methyltestosterone
  • Mifepristone
  • Miltefosine
  • Mycophenolate
  • Nabumetone
  • Nandrolone Decanoate
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Natural Antineoplastics
  • Nelarabine
  • Nintedanib
  • Nonsteroidal antiinflammatory drugs
  • Obinutuzumab
  • Omacetaxine
  • Oxandrolone
  • Oxaprozin
  • Pentosan
  • Phentermine; Topiramate
  • Piperacillin
  • Piperacillin; Tazobactam
  • Piroxicam
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Prasugrel
  • Reteplase, r-PA
  • Rivaroxaban
  • Rofecoxib
  • Salicylates
  • Salsalate
  • Selective serotonin reuptake inhibitors
  • Serotonin norepinephrine reuptake inhibitors
  • Sodium Hyaluronate, Hyaluronic Acid
  • Sodium Iodide
  • Streptokinase
  • Sulfinpyrazone
  • Sulindac
  • Telavancin
  • Tenecteplase
  • Thrombolytic Agents
  • Ticagrelor
  • Ticarcillin
  • Ticarcillin; Clavulanic Acid
  • Ticlopidine
  • Tinzaparin
  • Tipranavir
  • Tirofiban
  • Tolmetin
  • Topiramate
  • Trazodone
  • Treprostinil
  • Tretinoin, ATRA
  • Urokinase
  • Valdecoxib
  • Verteporfin
  • Vilazodone
  • Vorapaxar
  • Vorinostat
  • Vortioxetine
  • Warfarin
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