Amlodipine Hydrochlorothiazide Olmesartan Brand Name– Tribenzor
What is Amlodipine Hydrochlorothiazide Olmesartan
Amlodipine Hydrochlorothiazide Olmesartan is a triple combination product for the maintenance treatment of hypertension after titration of the individual components.
Amlodipine is a dihydropyridine calcium channel blocker; hydrochlorothiazide is a thiazide diuretic; and olmesartan is an angiotensin II receptor antagonist, also known as an angiotensin 2 receptor blocker (ARB).
The combination of an ARB with either a diuretic or a calcium-channel blocker results in additive blood pressure reduction. Combining drugs from complimentary classes is significantly more effective in lowering blood pressure than increasing the dose of one drug.
In the TRINITY study (Triple Therapy With Olmesartan medoxomil, Amlodipine, and Hydrochlorothiazide in Hypertensive Patients), there was a significantly greater reduction from baseline in both seated systolic and diastolic blood pressures at week 12 in the triple therapy group (-37.1 mmHg/-21.8 mmHg for amlodipine 10 mg; hydrochlorothiazide 25 mg; olmesartan 40 mg group) compared to dual combinations of amlodipine + olmesartan, hydrochlorothiazide + olmesartan, or amlodipine + hydrochlorothiazide (p < 0.001 for triple therapy compared to all dual treatment groups).
Patients with severe hypertension had a greater therapeutic response than those with moderate hypertension.
Additionally, significantly more patients in the triple therapy group vs. the other groups reached blood pressure targets of less than 140/90 mmHg, less than 120/80 mmHg, seated SBP less than 140 mmHg, and seated DBP less than 90 mmHg (p < 0.001).
Amlodipine Hydrochlorothiazide Olmesartan (Tribenzor) was initially approved by the FDA in July 2010.
Indications
- hypertension
Side Effects
- agranulocytosis
- alopecia
- angina
- angioedema
- aplastic anemia
- arthropathy
- atrial fibrillation
- azotemia
- blurred vision
- bradycardia
- cholestasis
- cough
- diarrhea
- dizziness
- dysphagia
- elevated hepatic enzymes
- erythema multiforme
- exfoliative dermatitis
- fatigue
- flatulence
- gingival hyperplasia
- gout
- gynecomastia
- headache
- hemolytic anemia
- hepatitis
- hyperbilirubinemia
- hypercalcemia
- hypercholesterolemia
- hyperglycemia
- hyperkalemia
- hypertriglyceridemia
- hyperuricemia
- hypomagnesemia
- hypotension
- infection
- jaundice
- leukopenia
- muscle cramps
- myopia
- nausea
- nephrolithiasis
- ocular hypertension
- orthostatic hypotension
- pancreatitis
- pancytopenia
- peripheral edema
- peripheral neuropathy
- pharyngitis
- photosensitivity
- purpura
- renal failure (unspecified)
- rhabdomyolysis
- Stevens-Johnson syndrome
- syncope
- teratogenesis
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
- vasculitis
- ventricular tachycardia
- vomiting
- weight loss
- xanthopsia
Monitoring Parameters
- blood glucose
- blood pressure
- heart rate
- LFTs
- serum bilirubin
- serum creatinine/BUN
- serum electrolytes
- serum uric acid
Contraindications
- ACE-inhibitor induced angioedema
- angina
- angioedema
- anuria
- aortic stenosis
- asthma
- breast-feeding
- closed-angle glaucoma
- coronary artery disease
- diabetes mellitus
- electrolyte imbalance
- geriatric
- gout
- heart failure
- hepatic disease
- hypercalcemia
- hyperglycemia
- hyperkalemia
- hyperuricemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypotension
- hypovolemia
- myopia
- orthostatic hypotension
- pancreatitis
- penicillin hypersensitivity
- pregnancy
- renal artery stenosis
- renal disease
- renal failure
- renal impairment
- sulfonamide hypersensitivity
- sunlight (UV) exposure
- systemic lupus erythematosus (SLE)
- thiazide diuretic hypersensitivity
Interactions
- Acarbose
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