Amlodipine and Olmesartan Brand Name– AZOR
What is Amlodipine and Olmesartan
Amlodipine and olmesartan are used together in an oral preparation for the treatment of hypertension, either alone or in combination with other antihypertensive agents.
Amlodipine is a calcium-channel blocker and a potent peripheral vasodilator. It has the longest half-life of the calcium-channel blocker group, thus allowing for once-daily dosing.
Olmesartan is an angiotensin II receptor antagonist that does not undergo further metabolism by the liver, lacks cytochrome P-450 interactions, and is eliminated via biliary and renal excretion.
Because olmesartan does not inhibit angiotensin converting enzyme (ACE), it does not result in bradykinin accumulation, which is theorized to cause the cough and angioedema associated with ACE inhibitors.
However, angioedema has been rarely associated with valsartan and other angiotensin II antagonists. The extent of blood pressure reduction with the combination of amlodipine and olmesartan is additive.
Data obtained from the trial used for registration show that amlodipine 10 mg plus olmesartan 40 mg results in a 53% greater reduction in the mean change of systolic blood pressure than amlodipine 10 mg alone.
Amlodipine and olmesartan is used as initial therapy for the treatment of hypertension in adults likely to need multiple antihypertensive agents to achieve their blood pressure goals or whose blood pressure is not adequately controlled on amlodipine or olmesartan alone or in those already being treated with both agents individually.
Amlodipine and olmesartan (Azor) was granted final FDA approval September 27, 2007.
Indications
- hypertension
For the treatment of hypertension, either alone or in combination with other antihypertensive agents
for initial therapy in patients likely to need multiple antihypertensive agents to achieve their blood pressure goals
Side Effects
- alopecia
- anaphylactoid reactions
- angioedema
- asthenia
- azotemia
- cholestasis
- cough
- diarrhea
- dizziness
- drowsiness
- edema
- elevated hepatic enzymes
- flushing
- gynecomastia
- headache
- hepatitis
- hyperkalemia
- hypotension
- increased urinary frequency
- jaundice
- nausea
- nocturia
- oliguria
- orthostatic hypotension
- palpitations
- peripheral vasodilation
- pruritus
- rash
- renal failure (unspecified)
- rhabdomyolysis
- syncope
- teratogenesis
- urticaria
- vomiting
- weight loss
Monitoring Parameters
- blood pressure
- heart rate
- LFTs
- serum creatinine/BUN
- serum potassium
Contraindications
- ACE-inhibitor induced angioedema
- angioedema
- aortic stenosis
- Black patients
- bradycardia
- breast-feeding
- cardiogenic shock
- coronary artery disease
- diabetes mellitus
- dihydropyridine hypersensitivity
- geriatric
- heart failure
- hepatic disease
- hyperkalemia
- hypotension
- hypovolemia
- pregnancy
- renal artery stenosis
- renal impairment
- surgery
Interactions
- Acarbose
- Acebutolol
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin; Metformin
- Alpha-glucosidase Inhibitors
- Alprostadil
- Amifostine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Amiodarone
- Amlodipine; Celecoxib
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Amprenavir
- Amyl Nitrite
- Angiotensin II
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- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
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- Benzonatate
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- Boceprevir
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- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bupivacaine; Lidocaine
- Cabergoline
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- Calcium Phosphate, Supersaturated
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- Carbinoxamine; Pseudoephedrine
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- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
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- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
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- Ethosuximide
- Ethotoin
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- Etomidate
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Famotidine; Ibuprofen
- Fedratinib
- Fenoprofen
- Fentanyl
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- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluconazole
- Fluoxetine
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- Flutamide
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- Fosphenytoin
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- Glipizide; Metformin
- Glyburide; Metformin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydantoins
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Iloperidone
- Iloprost
- Imatinib
- Incretin Mimetics
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- Isoproterenol
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- Itraconazole
- Ketamine
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- Labetalol
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- Metformin
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- Methadone
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- Nafcillin
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- Naproxen; Pseudoephedrine
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- Nebivolol; Valsartan
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- Nesiritide, BNP
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- Nevirapine
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- Pentoxifylline
- Perampanel
- Phenelzine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Photosensitizing agents (topical)
- Pindolol
- Piroxicam
- Polyethylene Glycol; Electrolytes
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- Procaine
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- Quinine
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