Amiloride

Amiloride Brand Name– Midamor

What is Amiloride

Amiloride is an oral potassium-sparing diuretic similar in action to triamterene. It is not a thiazide diuretic.

It is used in the treatment or prevention of hypokalemia associated with kaliuretic diuretics. It is also used in the management of edema and as an adjunct in hypertension.

Although amiloride has little antihypertensive or diuretic activity compared with other diuretics, some additive effects have been noted when it is used concurrently with the thiazide or loop diuretics.

The drug can be especially useful in patients who cannot tolerate or have been unresponsive to potassium supplements.

Amiloride was approved by the FDA in 1981.

Indications

1. ascites
2. edema
3. heart failure
4. hypertension
5. hypokalemia

For the adjunctive treatment of heart failure edema, hypertension, or hypokalemia

Side Effects

1. abdominal pain
2. alopecia
3. angina
4. anorexia
5. anxiety
6. aplastic anemia
7. arthralgia
8. back pain
9. bladder spasm
10. chest pain (unspecified)
11. confusion
12. constipation
13. cough
14. depression
15. diarrhea
16. dizziness
17. drowsiness
18. dyspepsia
19. dyspnea
20. dysuria
21. elevated hepatic enzymes
22. encephalopathy
23. flatulence
24. GI bleeding
25. gynecomastia
26. headache
27. hyperkalemia
28. hypochloremia
29. hyponatremia
30. impotence (erectile dysfunction)
31. increased urinary frequency
32. insomnia
33. jaundice
34. metabolic acidosis
35. musculoskeletal pain
36. myalgia
37. nasal congestion
38. nausea
39. neutropenia
40. orthostatic hypotension
41. palpitations
42. peptic ulcer
43. polyuria
44. pruritus
45. rash
46. tinnitus
47. tremor
48. vertigo
49. visual impairment
50. vomiting
51. weakness
52. xerostomia

Monitoring Parameters

• serum creatinine/BUN
• serum electrolytes

Contraindications

• acid/base imbalance
• anuria
• breast-feeding
• children
• diabetes mellitus
• diabetic nephropathy
• geriatric
• hepatic disease
• hyperkalemia
• hyponatremia
• metabolic acidosis
• pregnancy
• renal disease
• renal failure
• renal impairment
• respiratory acidosis

Interactions

• Abacavir; Dolutegravir; Lamivudine
• Abacavir; Lamivudine, 3TC
• Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Acetazolamide
• Acrivastine; Pseudoephedrine
• Adefovir
• Aldesleukin, IL-2
• Alemtuzumab
• Alfentanil
• Aliskiren
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• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Alprostadil
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• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Ambrisentan
• Amifostine
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• Amlodipine; Benazepril
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