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What is Acetaminophen and Ibuprofen
Acetaminophen and ibuprofen is an oral combination of a para-aminophenol analgesic and a non-steroidal anti-inflammatory drug (NSAID) indicated for the temporary relief of minor aches and pains due to headache, backache, muscular aches, toothache, menstrual cramps, or minor pain of arthritis.
All NSAIDs, including ibuprofen, cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and GI perforation of the esophagus, stomach, small intestine, or large intestine and are associated with an increased risk of serious cardiovascular (CV) thromboembolism, including myocardial infarction or stroke.
Use the lowest effective dose for the shortest possible duration; the increase in CV risk has been most consistently observed at higher doses.
Acetaminophen has a history of safe and effective use when used properly; however, unintentional or intentional misuse of acetaminophen is the leading cause of acute hepatic failure in the United States.
Indications
- mild pain
Side Effects
- Dizziness
- headache
- nervousness
- depression
- insomnia
- confusion
- emotional lability
- drowsiness
- anxiety
- asthenia
- malaise
- tremor
- vertigo
- seizures
- coma
- medication overuse headache
- rebound headache ( morning headache, end-of-dosing interval headache, or headache improvement with discontinuation of the overused medication)
- nausea
- vomiting
- anorexia
- abdominal pain
- malaise
Contraindications
- acute bronchospasm
- acute myocardial infarction
- alcoholism
- angina
- anticoagulant therapy
- asthma
- bone marrow suppression
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- cerebrovascular disease
- chemotherapy
- coagulopathy
- coronary artery bypass graft surgery (CABG)
- coronary artery disease
- corticosteroid therapy
- Crohn’s disease
- dehydration
- diabetes mellitus
- edema
- ethanol intoxication
- G6PD deficiency
- geriatric
- GI bleeding
- GI disease
- GI perforation
- heart failure
- hematological disease
- hemophilia
- hepatic disease
- hepatitis
- hepatotoxicity
- hypertension
- hypovolemia
- immunosuppression
- infection
- infertility
- labor
- malnutrition
- myocardial infarction
- nasal polyps
- neutropenia
- NSAID hypersensitivity
- obstetric delivery
- peptic ulcer disease
- peripheral vascular disease
- potential for overdose or poisoning
- pregnancy
- renal disease
- renal failure
- renal impairment
- reproductive risk
- rheumatoid arthritis
- salicylate hypersensitivity
- stroke
- surgery
- systemic lupus erythematosus (SLE)
- tachycardia
- thrombocytopenia
- thromboembolism
- tobacco smoking
- ulcerative colitis
- urticaria
Interactions
No information is available regarding drug interactions associated with Acetaminophen and Ibuprofen combination medicine
