Abciximab

Abciximab Brand Name – ReoPro

What is Abciximab

Abciximab was the first FDA-approved platelet glycoprotein IIb/IIIa inhibitor. It is the Fab fragment of the chimeric monoclonal antibody 7E3.

The substitution of human IgG for the murine IgG molecule produces a Fab fragment that causes fewer allergic and thrombocytopenic complications.

Abciximab was FDA-approved in December 1994. In November 1997, the FDA expanded the indications for abciximab to a broader range of patients undergoing PCI, including those with unstable angina not responding to conventional therapy.

Side Effects

1. abdominal pain
2. agitation
3. anaphylactic shock
4. anaphylactoid reactions
5. anemia
6. antibody formation
7. anxiety
8. asthenia
9. AV block
10. back pain
11. bleeding
12. bleeding
13. bradycardia
14. bronchospasm
15. bullous rash
16. chest pain (unspecified)
17. coma
18. confusion
19. diabetes mellitus
20. diarrhea
21. diplopia
22. dizziness
23. dyspepsia
24. dysuria
25. gastroesophageal reflux
26. GI bleeding
27. headache
28. hematemesis
29. hematuria
30. hemoptysis
31. hyperhidrosis
32. hyperkalemia
33. hypertonia
34. hypoesthesia
35. hypotension
36. ileus
37. increased urinary frequency
38. injection site reaction
39. intracranial bleeding
40. leukocytosis
41. myalgia
42. nausea
43. pallor
44. palpitations
45. peripheral edema
46. petechiae
47. phlebitis
48. platelet dysfunction
49. pleural effusion
50. prolonged bleeding time
51. prostatitis
52. pruritus
53. pulmonary embolism
54. retroperitoneal bleeding
55. stroke
56. thrombocytopenia
57. thrombocytopenia
58. thromboembolism
59. urinary incontinence
60. urinary retention
61. ventricular tachycardia
62. visual impairment
63. vomiting
64. xerostomia

Monitoring Parameters

• activated partial thromboplastin time (APTT)
• clotting time
• hemoglobin/hematocrit
• platelet count
• thrombin time

Contraindications

• abciximab hypersensitivity
• aneurysm
• anticoagulant therapy
• arteriovenous malformation
• bleeding
• breast-feeding
• children
• coagulopathy
• dextran therapy
• geriatric
• GI bleeding
• human anti-chimeric antibody (HACA)
• human anti-murine antibody (HAMA)
• hypertension
• infants
• intracranial mass
• intramuscular injections
• murine protein hypersensitivity
• pregnancy
• stroke
• surgery
• thrombocytopenia
• thrombolytic therapy
• trauma
• vasculitis
• venipuncture

Interactions

• Acetaminophen; Aspirin, ASA; Caffeine
• Ado-Trastuzumab emtansine
• ADP receptor antagonists
• Altretamine
• Aminolevulinic Acid
• Anagrelide
• Antimetabolites
• Antithrombin III
• Antithymocyte Globulin
• Apixaban
• Argatroban
• Arsenic Trioxide
• Aspirin, ASA
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Aspirin, ASA; Dipyridamole
• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Oxycodone
• Aspirin, ASA; Pravastatin
• Betrixaban
• Bexarotene
• Bivalirudin
• Chlorambucil
• Cilostazol
• Cladribine
• Clofarabine
• Collagenase
• Dabigatran
• Dalteparin
• Danaparoid
• Danazol
• Dasatinib
• Defibrotide
• Denileukin Diftitox
• Desirudin
• Desvenlafaxine
• Dipyridamole
• Drotrecogin Alfa
• Duloxetine
• Edoxaban
• Enoxaparin
• Estramustine
• Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
• Fludarabine
• Folate analogs
• Fondaparinux
• Garlic, Allium sativum
• Ginger, Zingiber officinale
• Ginkgo, Ginkgo biloba
• Green Tea
• Heparin
• Ibritumomab Tiuxetan
• Ibrutinib
• Icosapent ethyl
• Iloprost
• Imatinib
• Inotersen
• Intravenous Lipid Emulsions
• Lepirudin
• Levomilnacipran
• Lomustine, CCNU
• Mercaptopurine, 6-MP
• Methoxsalen
• Methylsulfonylmethane, MSM
• Milnacipran
• Mycophenolate
• Nelarabine
• Nonsteroidal antiinflammatory drugs
• Obinutuzumab
• Pegaspargase
• Pentosan
• Pentostatin
• Pentoxifylline
• Phentermine; Topiramate
• Photosensitizing agents (topical)
• Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
• Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
• Purine analogs
• Rivaroxaban
• Selective serotonin reuptake inhibitors
• Selumetinib
• Sodium Hyaluronate, Hyaluronic Acid
• Sulfinpyrazone
• Thioguanine, 6-TG
• Thrombolytic Agents
• Tinzaparin
• Tipranavir
• Topiramate
• Trazodone
• Treprostinil
• Tretinoin, ATRA
• Venlafaxine
• Verteporfin
• Vilazodone
• Vorapaxar
• Vorinostat
• Vortioxetine
• Warfarin