Who is credited with the early naming and descriptions of SLE?
1230—Rogerius Frugardi, a surgeon at the medical school in Salerno, used the term lupus (latin for “wolf”) to describe ulcerative skin lesions that were reminiscent of what would be caused by a wolf’s bite. Most of these referred to lesions on extremities (not the face) and were probably due to tuberculosis, syphilis, or cancer.
1500–1800—Paracelsus and others used the term lupus to describe ulcerative skin lesions from any cause. Attempts made at identifying subtypes.
1808—Robert Willan, considered the founder of British dermatology, describes lupus vulgaris due to tuberculosis causing lesions with ulcerations on the face.
1833— Laurant Biett with student Pierre Cazenave described and published description of discoid lupus on the face and called it “erythema centrifugum.”
1845—Ferdinand von Hebra described the butterfly rash on the nose and cheeks. Separates skin lupus from lesions caused by tuberculosis and syphilis.
1852—Pierre Cazenave coined the term lupus erythemateux. Published it in the first dermatology textbook (1856), Atlas of Skin Diseases.
1872—Moritz Kaposi, who was a student and son-in-law of von Hebra, separated discoid lupus from systemic “disseminated” lupus.
1895–1903—Sir William Osler describes the systemic features under the name “ erythema exudativum multiforme with visceral injuries.” Describes renal and central nervous system involvement.
1904–1940— Other lupus manifestations described: pulmonary (1908), Libman-Sacks endocarditis (1923), leukopenia and photosensitivity (1939).
1948—Malcolm Hargraves described the lupus erythematosus cell in bone marrow aspirates.
1949— J.R. Haserick reported that the “LE cell factor” are immunoglobulins in lupus patients’ sera reacting with bone marrow cells.
1954—Peter Miescher described the absorption of the “LE cell factor” by cell nuclei.
1957—Multiple investigators including Henry Kunkel described antibodies against dsDNA in lupus sera.
1958—George Friou described the method identifying antinuclear antibodies by labeling with fluorescent antihuman globulin.
1959–1975—Henry Kunkel and his investigators at the Rockefeller identified antibodies reacting with “extractable nuclear antigens” including Sm, Ro, and La.