Hematologic manifestations in SLE

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What are the hematologic manifestations in SLE?

• Autoimmune hemolytic anemia (AIHA)

• Leukopenia (lymphopenia [common], neutropenia)

• Thrombocytopenia

• Antiphospholipid antibody syndrome (APLAS) (: Antiphospholipid Antibody Syndrome)

• Anemia of chronic disease

• Thrombotic thrombocytopenic purpura (TTP)

• Macrophage activation syndrome (MAS)

• Rare but can be fatal (fever, cytopenias, organ dysfunction, splenomegaly, low erythrocyte sedimentation rate [ESR] due to inability of the liver to synthesize proteins such as fibrinogen, high triglycerides, high ferritin, high IL-2 receptor [CD25]). R/O EBV or CMV infection as a trigger.

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