Which primary malignant tumor of joints may be difficult to differentiate from the benign cartilaginous metaplasia of synovial chondromatosis?
Occasionally arising from synovial chondromatosis, synovial chondrosarcoma is an exceedingly rare malignancy that may be histologically difficult to differentiate from its benign cousin. Favoring a diagnosis of sarcoma is the loss of a differentiated clustering growth pattern, areas of necrosis, spindling of cells in the periphery, and permeation of invaded bone.
